Derivatives of 4-aminopiperidine and their use as a medicament
View Patent ↗A subject of the present application is new derivatives of 4-aminopiperidines of formula in which R 1 , R 2 and R 3 represent various radical, and their preparation processes by synthetic methods in parallel in liquid and solid phase. These products having a good affinity with certain sub-types of somatostatin receptors, they are particularly useful for treating the pathological states or diseases in which one (or more) somatostatin receptors are involved.
1. Compounds of the general formula:
in racemic, enantiomeric form or all combinations of these forms, in which:
R 1 represents a —(CH 2 ) m —Z 12 radical in which Z 12 represents optionally substituted aryl;
R 2 represents a radical of formula —C(Y)NHX 1 , wherein X 1 represents a (CH 2 ) p —Z 22 radical in which Z 22 represents aryl optionally substituted;
R 3 represents an optionally substituted alkyl;
Y represents an oxygen or a sulphur atom;
m is an integer from 1 to 6; and
p is an integer from 0 to 6;
or their addition salts with pharmaceutically acceptable mineral or organic acids.