Medical procedure
View Patent ↗The use of an intravascular cooling element to induce hypothermia in connection with a medical procedure. According to a first aspect of the present, invention, a coronary bypass procedure is conducted in which a patient's blood is oxygenated with the patient's lungs and in which blood is circulated using the patient's heart or using an intracorporeal pump. The procedure preferably comprises: (a) positioning a heat transfer element in a blood vessel of a patient; (b) cooling the body of the patient to less than 35° C., more preferably 32±2° C., using the heat transfer element; and (c) forming a fluid communicating graft between an arterial blood supply and the coronary artery. The body of the patient is preferably heated to about 37° C. using the heat transfer element subsequent to the step of forming the fluid communicating graft. According to a further aspect of the invention, a hypothermic medical procedure is provided while a patient is in a conscious or semiconscious state, comprising (a) administering a beta-blocking drug to the patient; (b) delivering a heat transfer element to a blood vessel of the patient; and (c) cooling a region of the patient or the body of the patient to less than 35° C. using the heat transfer element.
1. A hypothermic medical procedure comprising:
administering a beta-blocking drug to a patient;
delivering a heat transfer element to a blood vessel of the patient, wherein the heat transfer element comprises:
an inlet lumen to introduce a circulating working fluid; and
an outlet lumen to extract a circulating working fluid, the outlet lumen having a helical shape to induce turbulence in blood flowing past the outlet lumen and in the working fluid; and
cooling a region of the patient or the body of the patient to less than 35.degree. C. using said heat transfer element while said patient is in a conscious or semiconscious state.
2. The procedure of claim 1 , wherein the beta-blocking drug is a β1 blocker.
3. The procedure of claim 2 , wherein the β1 blocker is selected from one or more of acebutolol, atenolol, betaxolol, bisoprolol, esmolol and metoprolol.
4. The procedure of claim 1 , wherein the beta-blocking drug is a β1β2 blocker.
5. The procedure of claim 4 , wherein the β1β2 blocker is selected from one or more of carteolol, nadolol, penbutolol, pindolol, propranolol, sotalol and timolol.
6. The procedure of claim 4 , wherein the {acute over (α)}β1β2 blocker is selected from one or more of carvedilol and labetalol.
7. The procedure of claim 1 , wherein the beta-blocking drug is an {acute over (α)}β1β2 blocker.
8. The procedure of claim 1 , wherein the beta-blocking drug is administered after delivering the heat transfer element.
9. The procedure of claim 1 , wherein the body of the patient is cooled.
10. The procedure of claim 1 , wherein an organ of the patient is cooled.