Polymer coated spinulose metal surfaces
Spinulose surfaces such as titanium and zirconium can be coated with a range of polymers used to form thin, adherent polymer surface films. Selected polymer coatings are useful for use as biocompatible surfaces on implants, catheters, guidewires, stents and a variety of medical devices for in vivo applications. The polymer coatings can also be used to protect metal surfaces nanostructured with spinulose titanium or zirconium.
1 - 21 . (canceled)
22 . A polymer or copolymer coated nanoplasma deposited titania or zirconium surface having nanosized spike-like thorny protrusions (spinulose) emanating radially from rounded surface deposited metal nanoparticles on a substrate.
23 . The coated spinulose surface of claim 22 which exhibits enhanced surface adherence for the polymer or copolymer compared to a smooth titanium surface coated with said polymer of copolymer.
24 . The coated surface surface of claim 22 comprising deposited spinulose titanium and zirconium.
25 . The polymer coated surface of claim 22 which is on a titanium spinulose surface.
26 . The polymer coated surface of claim 22 wherein the polymer is a biodegradable polymer or copolymer.
27 . The polymer coated surface of claim 26 wherein the biodegradable polymer or copolymer is poly-L-lactic acid (PLLA), poly-lactic-co-glycolic acid) (PLGA) or a combination of PLLA and PLGA.
28 . The polymer coated surface of claim 25 wherein the polymer is bound to a bioactive agent.
29 . The polymer coated surface of claim 28 wherein the bioactive agent is an antimicrobial agent.
30 . A medical device comprising a polymer coated nanorough titanium or zirconium spinulose surface characterized by round nanoparticulates with radially disposed nanosized spike-like projections.
31 . The device of claim 30 wherein the spinulose surface is titanium.
32 . The device of claim 30 wherein the device is a stent, guidewire, catheter or implant.
33 . The device of claim 30 wherein the titanium or zirconium spinulose surface is on a metal, polymer or ceramic substrate.
34 . The device of claim 30 wherein the polymer coating is a biodegradable polymer or copolymer.
35 . The device of claim 30 wherein a bioactive agent is attached or adhered to the spinulose surface.
36 . The device of claim 29 wherein the spinulose surface is nanodeposited titanium and zirconium.