IP Library Granted Patent US 8,001,876
Granted Patent B1
US 8,001,876 · App. 12/153,110 · Granted Aug 23, 2011

Block alignment for microtomes

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Quick Facts
Patent No.
US 8,001,876
App. No.
12/153,110
Granted
Aug 23, 2011
Kind
B1
Abstract

Systems and methods described herein for aligning a block in a microtome attempt to save time, money, and the sample by aligning a block in any rotary or cryostat microtome. One such device for aligning a block in a microtome has a knife holder component removably attached to a knife holder of the microtome and a pin alignment component extending vertically from the knife holder component in a direction substantially parallel to the block. The pin alignment component has a plurality of front pins extending from a front surface of the pin alignment component configured to slide in response to an angle of the block and a plurality of rear pins extending from a rear surface of the pin alignment component and coupled to the front pins. The rear pins are configured to indicate the extension of the front pins from the pin alignment component.

Claims (26)

1. A device for aligning a block specimen in a microtome, the device comprising:

a knife holder component removably attached to a knife holder of the microtome;

a pin alignment component extending vertically from the knife holder component in a direction substantially parallel to the block specimen, the pin alignment component comprising:

a plurality of front pins extending from a front surface of the pin alignment component configured to slide in response to an angle of the block specimen; and

a plurality of rear pins extending from a rear surface of the pin alignment component and coupled to the front pins; and

an angle indicator indicating an angle between the knife holder component and the pin alignment component;

wherein the rear pins are configured to indicate the extension of the front pins from the pin alignment component.

2. The device according to claim 1 , wherein the rear pins have indicia of at least two colors.

3. The device according to claim 1 , wherein the rear pins have alphabetic or numeric indicia.

4. The device according to claim 1 , wherein the front pins are arranged along a horizontal axis and a vertical axis of the front surface of the pin alignment component.

5. The device according to claim 1 , wherein the rear pins are arranged substantially along the perimeter of the rear surface of the pin alignment component.

6. The device according to claim 1 , further comprising a contact surface component that engages the front pins, wherein the contact surface component is configured to contact the block specimen.

7. The device according to claim 6 , further comprising a film extending across a front surface of the contact surface component.

8. The device according to claim 7 , wherein the film removably attaches using electrostatic forces.

9. A device for aligning a block specimen in a microtome, the device comprising:

a knife holder component removably attached to a knife holder of the microtome;

a pin alignment component extending vertically from the knife holder component in a direction substantially parallel to the block specimen, the pin alignment component comprising:

a plurality of front pins extending from a front surface of the pin alignment component configured to slide in response to an angle of the block specimen; and

a plurality of rear pins extending from a rear surface of the pin alignment component and coupled to the front pins; and

at least one lever for coupling a front pin with a rear pin;

wherein the rear pins are configured to indicate the extension of the front pins from the pin alignment component.

10. The device according to claim 9 , further comprising a spring configured to allow the at least one lever to reset to a starting position.

11. The device according to claim 9 , wherein the at least one lever comprises:

a first lever configured to move when a force is applied to a front pin:

a second lever configured to move when the first lever moves; and

a third lever configured to move when the second lever moves and configured to move a rear pin.

Assignments (6)
RELEASE OF SECURITY INTEREST Recorded Jan 17, 2020
From: CITIBANK, N.A., AS COLLATERAL AGENT
To: LEIDOS, INC.
Reel/Frame 051632/0742 →
RELEASE OF SECURITY INTEREST Recorded Jan 17, 2020
From: CITIBANK, N.A., AS COLLATERAL AGENT
To: LEIDOS, INC.
Reel/Frame 051632/0819 →
SECURITY INTEREST Recorded Aug 25, 2016
From: LEIDOS, INC.
To: CITIBANK, N.A.
Reel/Frame 039809/0801 →
SECURITY INTEREST Recorded Aug 25, 2016
From: LEIDOS, INC.
To: CITIBANK, N.A.
Reel/Frame 039818/0272 →
CHANGE OF NAME Recorded Jun 11, 2014
From: SAIC-FREDERICK, INC.
To: LEIDOS BIOMEDICAL RESEARCH, INC.
Reel/Frame 033125/0241 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded May 14, 2008
From: TABB, BRIAN CARROLL; ROGERS, KEITH
To: SAIC-FREDERICK, INC.
Reel/Frame 021003/0037 →