Treating allergic and inflammatory conditions

1. A method of treating seasonal or perennial allergic rhinitis in a human of 12 years and older which comprises administering an effective amount of desloratadine for a time sufficient to produce a geometric mean steady state maximum plasma concentration of 3-OH-desloratadine in the range of about 1.50 ng/mL to about 2.34 ng/mL, or an arithmetic mean steady state maximum plasma concentration of 3-OH-desloratadine in the range of about 1.60 ng/mL to about 2.50 ng/mL.

2. The method of claim 1 wherein a geometric mean T max is in the range of about 4.00 to about 6.25 hours.

3. The method of claim 1 wherein an arithmetic mean steady state maximum plasma concentration of 3-OH-desloratadine in the range of about 1.60 ng/mL to about 2.50 ng/mL is produced.

4. The method of claim 1 wherein an arithmetic mean T max is in the range of about 3.80 to about 5.95 hours.

5. The method of claim 1 wherein the amount of desloratadine is about 5.0 mg/day, in single or divided doses.

6. The method of claim 1 wherein a geometric mean AUC(0-24 hr) for 3-OH-desloratadine is in the range of about 24.3 ng.hr/mL to about 38.0 ng.hr/mL.

7. The method of claim 1 wherein an arithmetic mean AUC(0-24 hr) for 3-OH-desloratadine is in the range of about 25.8 ng.hr/mL to about 40.4 ng.hr/mL.

8. A method of treating atopic dermatitis or urticaria in a human of 12 years and older which comprises administering an effective amount of desloratadine for a time sufficient to produce a geometric mean steady state maximum plasma concentration of 3-OH-desloratadine in the range of about 1.50 ng/mL to about 2.34 ng/mL, or an arithmetic mean steady state maximum plasma concentration of 3-OH-desloratadine in the range of about 1.6 ng/mL to about 2.50 ng/mL.

9. The method of claim 8 wherein a geometric mean T max , of 3-OH-desloratadine is in the range of about 4.00 to about 6.25 hours.

10. The method of claim 8 wherein an arithmetic mean T max of 3-OH-desloratadine is in the range of about 3.80 to about 5.95 hours.

11. The method of claim 8 wherein the amount of desloratadine is about 5.0 mg/day, in single or divided doses.

12. The method of claim 8 wherein a geometric mean AUC(0-24 hr) for 3-OH-desloratadine is in the range of about 24.3 ng.hr/mL to about 38.0 ng.hr/mL.

13. The method of claim 8 wherein an arithmetic mean AUC(0-24 hr) for 3-OH-desloratadine is in the range of about 25.8 ng.hr/mL to about 40.4 ng.hr/mL.

14. A method of treating the nasal and non-nasal symptoms of seasonal and perennial allergic rhinitis and for treating chronic idiopathic urticaria in a human which comprises administering to said human about 5.0 mg of desloratadine once a day for about 10 days to produce a mean time to maximum plasma concentration (T max ) of about 3 hours post dose, a steady state maximum plasma concentration (C max ) of desloratadine of about 4 ng/mL, and an area under the concentration-time curve of about 56.9 ng.hr/mL of desloratadine, wherein a mean steady state maximum plasma concentration (C max ) of 3-OH-desloratadine produced post dose at a mean time to maximum plasma concentration (T max ) of about 4.8 hours, is about 2 ng/mL, and an area under the concentration-time curve of 3-OH-desloratadine is in the range of about 25.8 ng.hr/mL to about 40.4 ng.hr/mL.

15. The method of claim 14 wherein a mean AUC(0-24 hr) for 3-OH-desloratadine is about 32.3 ng.hr/mL.

16. A method of treating the nasal and non-nasal symptoms of seasonal and perennial allergic rhinitis and/or of treating chronic idiopathic urticaria in a human which comprises administering an effective amount of desloratadine for a time sufficient to produce a steady state geometric mean plasma concentration of desloratadine in the range of about 2.90 ng/mL to about 4.54 ng/mL, or a steady state arithmetic mean maximum plasma concentration of desloratadine in the range of about 3.2 ng/mL to about 5.0 ng/mL, wherein an arithmetic mean steady state maximum plasma concentration (C max ) of 3-OH-desloratadine produced post dose at arithmetic mean time to maximum plasma concentration (T max ) in the range of about 3.80 hours to about 5.95 hours, is in the range about 1.60 ng/mL to about 2.50 ng/mL, and an area under the concentration-time curve of 3-OH-desloratadine was in the range of about 25.8 ng.hr/mL to about 40.4 ng.hr/mL.

17. A method of treating chronic idiopathic urticaria in a human of 12 years and older which comprises administering to said human about 5.0 mg of desloratadine once a day for about 10 days to produce at a mean time to maximum plasma concentration (T max ) of about 3 hours post dose, a mean steady state maximum plasma concentration (C max ) of desloratadine of about 4 ng/mL, and an area under the concentration-time curve of about 56.9 ng.hr/mL of desloratadine, wherein a mean steady state maximum plasma concentration (C max ) of 3-OH-desloratadine produced at a mean time to maximum plasma concentration (T max ) of about 4.80 hours post dose, is about 2.0 ng/mL, and an area under the concentration-time curve of 3-OH-desloratadine is about 32.3 ng.hr/mL.

18. A method of treating the nasal and non-nasal symptoms of seasonal and perennial allergic rhinitis in a human of 12 years and older which comprises administering to said human about 5.0 mg of desloratadine once a day for about 10 days to a produce at a mean time to maximum plasma concentration (T max ), of about 3 hours post dose, a mean steady state maximum plasma concentration (C max ) of desloratadine of about 4 ng/mL, and an area under the concentration-time curve of about 56.9 ng.hr/mL of desloratadine, wherein a mean steady state maximum plasma concentration (C max ) of 3-OH-desloratadine produced at a mean time to maximum plasma concentration (T max ) of about 4.80 hours post dose, is about 2.0 ng/mL, and an area under the concentration-time curve of 3-OH-desloratadine is about 32.3 ng.hr/mL.