SONICATION METHODS FOR SCREENING AND PREPARING SOLID FORMS
Methods for screening and preparing solid forms are described herein. Such methods comprise sonicating a solid paste to provide a sonicated paste. The sonicated paste may be analyzed for the presence of solid forms.
1 . A method of screening for a solid form comprising sonicating a solid paste to provide a sonicated paste and analyzing the sonicated paste for the presence of a solid form.
2 . The method of claim 1 wherein the solid paste comprises at least one active agent and a suitable liquid.
3 . The method of claim 2 wherein the at least one active agent is an active pharmaceutical ingredient.
4 . The method of claim 2 wherein solid paste further comprises at least one guest.
5 . The method of claim 2 wherein the at least one active agent is an active pharmaceutical ingredient.
6 . The method of claim 1 , wherein the sonicated paste is analyzed by an analytical technique selected from x-ray powder diffraction, solid-state NMR, Raman spectroscopy, and infrared spectroscopy.
7 . The method of claim 5 wherein the sonicated paste is analyzed by an analytical technique selected from x-ray powder diffraction, solid-state NMR, Raman spectroscopy, and infrared spectroscopy.
8 . The method of claim 6 wherein the analytical technique is x-ray powder diffraction.
9 . The method of claim 7 wherein the analytical technique is x-ray powder diffraction.
10 . The method of claim 5 wherein the suitable liquid is selected from acetone, acetonitrile, dichloromethane, diethyl ether, diisopropyl ether, dioxane, dimethylformamide, dimethyl sulfoxide, ethanol, ethyl acetate, heptane, hexanes, propan-2-ol, methanol, tetrahydrofuran, toluene, and water.
11 . The method of claim 5 wherein the suitable liquid is an organic solvent.
12 . The method of claim 4 wherein the sonicated paste contains a cocrystal.
13 . The method of claim 2 wherein the sonicated paste contains a polymorph.
14 . The method of claim 8 wherein the sonicated paste contains a cocrystal.
15 . A method of preparing a solid form comprising sonicating a solid paste to provide a sonicated paste.
16 . The method of claim 15 wherein the solid form is a cocrystal.
17 . The method of claim 15 wherein the solid form is a polymorph.
18 . The method of claim 15 wherein the solid form is selected from allotropes, solvates, hydrates, amorphous compounds, mesophases, liquid crystals, and salts.
19 . The method of claim 15 wherein the solid form is a salt.
20 . The method of claim 1 wherein the solid form is a salt.