Method for preparation of amorphous, anhydrous crystalline or hydrated crystalline docetaxel

1. A method for the preparation of amorphous docetaxel, comprising:

dissolving a docetaxel-containing matter or docetaxel in a polar solvent at a concentration of 1 to 30% (w/v);

adding the above-obtained solution to a non-polar solvent of 5 times or higher thereof by volume to cause precipitation; and

filtrating and drying the produced precipitate to obtain amorphous docetaxel, wherein the polar solvent is at least one selected from the group consisting of dichloromethane, chloroform and acetone, and the non-polar solvent is at least one selected from the group consisting of hexane, pentane, cyclohexane, cyclopentane and dialkylether.

2. A method for the preparation of anhydrous crystalline docetaxel, comprising:

mixing 1 to 30% (w/v) of a docetaxel-containing matter or docetaxel and acetone and colloidizing it in a suspended state; and

evaporating the acetone among the obtained colloid solution at 35° C. to 40° C. and drying it under a reduced pressure to obtain anhydrous crystalline docetaxel of fine powders.

3. A method for the preparation of hydrated crystalline docetaxel, comprising:

dissolving a docetaxel-containing matter of docetaxel in a mixed solvent of an organic solvent and purified water having a mixing ratio of 7:0.5 to 7:5 by volume or a mixed solvent of an organic solvent and a buffer solution having a mixing ratio of 7:0.5 to 7:5 by volume at a concentration of 0.1 to 5% (w/v);

producing a precipitate by evaporating the obtained solution at 35° C. to 40° C., thereby eliminating the organic solvent among the mixed solvent; and

filtrating the obtained precipitate at a reduced pressure and drying it to prepare hydrated crystalline docetaxel, wherein the organic solvent is at least one selected from the group consisting of methanol, ethanol, propanol, acetone and acetonitrile, and the hydrated crystalline docetaxel is dihydrate.