FORMULATIONS OF LOW OIL CONTENT COMPRISING DIPHENYLMETHANE DERIVATIVES
The present invention relates to specific (cosmetic) formulations for improving the bioavailability and activity of skin- or hair-lightening or senile keratosis-reducing diphenylmethane derivatives (tyrosinase inhibitors) of the following formula 1:
1 . A cosmetic and/or pharmaceutical formulation, comprising a tyrosinase-inhibiting amount of one or more compounds of the formula 1:
wherein:
R1 is
hydrogen,
methyl,
straight-chain or branched, saturated or unsaturated alkyl having 2-4 C atoms,
OH or
halogen,
R2 is
hydrogen,
methyl or
straight-chain or branched, saturated or unsaturated alkyl having 2-5 C atoms,
R3 is
methyl or
straight-chain or branched, saturated or unsaturated alkyl having 2-5 C atoms,
and
R4 and R5 are, independently of one another,
hydrogen,
methyl,
straight-chain or branched, saturated or unsaturated alkyl having 2-5 C atoms,
OH or
halogen
and an oily phase, wherein the content of the oily phase in the formulation is 0.05 to 12 wt. %.
2 . The formulation according to claim 1 , wherein the compound of the formula 1 is styrylresorcinol.
3 . The formulation according to claim 1 , further comprising a water content of from 25 to 95 wt. %, based on the total weight of the formulation.
4 . The formulation according to claim 1 , wherein the formulation is in the form of an O/W emulsion.
5 . The formulation according to claim 1 , further comprising at least one UV filter.
6 . The formulation according to claim 1 , further comprising a total amount of UV filters and/or inorganic pigments such that the formulation according to the invention has a sunscreen factor of greater than or equal to 2.
7 . The formulation according to claim 1 , further comprising a further skin- and/or hair-lightening active compound.
8 . The formulation according to claim 1 , further comprising a cooling active compound in an amount sufficient to achieve a skin-cooling effect.
9 . The formulation according to claim 1 , further comprising one or more compounds for care and/or cleansing of (a) skin and/or (b) hair.
10 . The formulation according to claim 1 , further comprising a sensorially active amount of one or more odoriferous substances.
11 . A method for lightening skin and/or hair and/or for reducing senile keratosis, comprising the step:
application of a formulation according to claim 1 to skin and/or hair.
12 . A process for the preparation of a formulation for lightening skin and/or hair and/or for reducing senile keratosis, comprising the step:
mixing of a compound of the formula 1 according to claim 1 with an oily phase, wherein the weight content of the oily phase in the finished formulation is 0.05 to 12 wt. %.
13 . The formulation according to claim 1 , wherein the water content is from 40 to 90 wt. %.
14 . The formulation according to claim 1 , wherein the at least one UV filter is present at least in an amount which prevents discolouration of the formulation caused by (sun)light.
15 . The formulation according to claim 1 , wherein the formulation has a sunscreen factor of greater than or equal to 5.
16 . The formulation according to claim 1 , wherein the further skin- and/or hair-lightening active compound is present in an amount which has a skin- or hair-lightening action.