Method for preparing 3-hydroxytetrahydrofuran using cyclodehydration
View Patent ↗Disclosed is a method of preparing 3-hydroxytetrahydrofuran using cyclodehydration. More particularly, this invention relates to a method of preparing 3-hydroxytetrahydrofuran, including subjecting 1,2,4-butanetriol to cyclodehydration under reaction conditions of a reaction temperature of 30˜180° C. and reaction pressure of 5000 psig or less in the presence of a strong acid cation exchange resin catalyst having a sulfonic acid group as an exchange group. According to the method of this invention, 3-hydroxytetrahydrofuran can be economically prepared at higher yield and productivity than when using conventional methods.
1. A method of preparing 3-hydroxytetrahydrofuran using cyclodehydration, comprising subjecting 1,2,4-butanetriol to cyclodehydration at a reaction temperature of 50-150° C. and reaction pressure of 5000 psig or less using a batch type or continuous fixed-bed reactor in the presence of a strong acid ion exchange resin catalyst, to thus obtain 3-hydroxytetrahydrofuran.
2. The method according to claim 1 , wherein the acid ion exchange resin has a sulfonic acid group (—SO 3 H) as an exchange group.
3. The method according to claim 2 , wherein the acid ion exchange resin is a copolymer of styrene and divinylbenzene.
4. The method according to claim 1 , wherein the reaction pressure is 1500 psig or less.
5. The method according to claim 1 , wherein weight hourly space velocity is 0.1-30 h −1 when the cyclodehydration is conducted in a continuous fixed-bed reactor.
6. The method according to claim 5 , wherein the weight hourly space velocity is 0.2-20 h −1 .
7. The method of claim 1 , wherein an optically pure 1,2,4-butanetriol is used and the 3-hydroxytetrahydrofuran obtained is optically pure.