Biodegradable phosphoester polyamines

1. A biocompatible composition comprising:

a biodegradable phosphoester polyamine of the following formula:

wherein R 1 is selected from the group consisting of polyethers, polyesters, poly(ether-ester) blocks and combinations thereof, R 2 is a hydrogen atom, a protecting group or an organic moiety having from about 1 to about 50 carbon atoms, and NH—R 3 —NH 2 is derived from a polyamine selected from the group consisting of ethylene diamine, hexamethylene diamine, lysine, N-(3-aminopropyl)-1,4-butanediamine, N,N′-bis(3-aminopropyl)-1,4-butanediamine, isomers of hexamethylene diamine, diethylene triamine, triethylene tetramine, tetraethylene pentamine, bishexamethylene triamine, N,N′-bis(3-aminopropyl)-1,2-ethane diamine, N-(3-Aminopropyl)-1,3-propane diamine, N-(2-aminoethyl)-1,3 propane diamine, cyclohexane diamine, isomers of cyclohexane diamine, 4,4′-methylene biscyclohexane amine, 4′4′-methylene bis(2-methylcyclohexanamine), toluene diamine, phenylene diamine, isophorone diamine, phenalkylene polyamines, amino-functionalized polyalkylene oxides, polypeptides, and combinations thereof.

2. The biocompatible composition of claim 1 , wherein R 1 comprises a polyether selected from the group consisting of polyethylene glycol, methoxy polyethylene glycol, polypropylene glycol, polybutylene glycol, polytetramethylene glycol, polyhexamethylene glycol, copolymers thereof, and combinations thereof.

3. The biocompatible composition of claim 1 , wherein R 1 comprises a polyester selected from the group consisting of trimethylene carbonate, ε-caprolactone, p-dioxanone, glycolide, lactide, 1,5-dioxepan-2-one, polybutylene adipate, polyethylene adipate, polyethylene terephthalate, and combinations thereof.

4. The biocompatible composition of claim 1 , wherein R 1 comprises a poly(ether-ester) block selected from the group consisting of polyethylene glycol-polycaprolactone, polyethylene glycol-polylactide, polyethylene glycol-polyglycolide, and combinations thereof.

5. The biocompatible composition of claim 1 , wherein R 1 is selected from the group consisting of polyethylene glycol, methoxy polyethylene glycol, glycolide-polyethylene glycol-caprolactone copolymers, aliphatic oligoesters, and combinations thereof.

6. An adhesive comprising the biocompatible composition of claim 1 .

7. A sealant comprising the biocompatible composition of claim 1 .

8. A biocompatible composition comprising:

an isocyanate prepolymer; and

a biodegradable phosphoester polyamine of the following formula:

wherein R 1 is selected from the group consisting of polyethers, polyesters, poly(ether-ester) blocks and combinations thereof, R 2 is a hydrogen atom, a protecting group or an organic moiety having from about 1 to about 50 carbon atoms, and NH—R 3 —NH 2 is derived from a polyamine selected from the group consisting of ethylene diamine, hexamethylene diamine, lysine, N-(3-aminopropyl)-1,4-butanediamine, N,N′-bis(3-aminopropyl)-1,4-butanediamine, isomers of hexamethylene diamine, diethylene triamine, triethylene tetramine, tetraethylene pentamine, bishexamethylene triamine, N,N′-bis(3-aminopropyl)-1,2-ethane diamine, N-(3-Aminopropyl)-1,3-propane diamine, N-(2-aminoethyl)-1,3 propane diamine, cyclohexane diamine, isomers of cyclohexane diamine, 4,4′-methylene biscyclohexane amine, 4′4′-methylene bis(2-methylcyclohexanamine), toluene diamine, phenylene diamine, isophorone diamine, phenalkylene polyamines, amino-functionalized polyalkylene oxides, polypeptides, and combinations thereof,

wherein the biodegradable phosphoester polyamine crosslinks the isocyanate prepolymer.

9. The biocompatible composition of claim 8 , wherein the isocyanate prepolymer is of the formula

wherein X is selected from the group consisting of polyethers, polyesters and polyether-esters, and R is selected from the group consisting of aromatic groups, aliphatic groups, and alicyclic groups.

10. A method for adhering tissue comprising:

approximating a first tissue surface and a second tissue surface; and

applying the biocompatible composition of claim 8 to the approximated first and second tissue surfaces to adhere the first tissue surface to the a second tissue surface.

11. A method for adhering a medical device to a tissue surface, the method comprising:

approximating a medical device and a tissue surface; and

applying the biocompatible composition of claim 8 to the medical device, to the tissue surface, or both,

wherein applying the biocompatible composition adheres the medical device to the tissue surface.