Lubricious echogenic coatings
Medical devices can include a lubricious echogenic coating that is slippery when wet and provides visibility during ultrasonic imaging.
1 . A medical device comprising a surface coated with a first layer proximal to the surface, a second layer coated on the first layer, the second layer including a plurality of microparticles, and a third layer coated on the second layer, at least one layer including an echogenic structure.
2 . The device of claim 1 , wherein the first layer includes an ethylene acrylic acid copolymer and an isocyanate.
3 . The device of claim 1 , wherein the second layer includes a plurality of microparticles.
4 . The device of claim 3 , wherein the plurality of microparticles includes a polymeric gas/liquid containing microparticle.
5 . The device of claim 1 , wherein the third layer includes a cellulose based polymer.
6 . The device of claim 1 , wherein the device is a needle, a vascular dilator, a guide wire, a stent, a biopsy site marker, a retrieval snare, a trocar, a hemostasis valve, or a brachytherapy seed.
7 . The device of claim 6 , wherein the needle is a disposable soft tissue biopsy needle, an aspiration needle, a bone marrow biopsy needle, a breast localization needle, an injection needle, a biopsy co-axial introducer needle, a bone biopsy needle, a guidewire introducer needle, an epidural needle, or a Huber needle.
8 . The device of claim 6 , wherein the device is a vascular retrieval snare.
9 . A medical device comprising a surface coated with a first layer proximal to the surface, the first layer including an ethylene acrylic acid copolymer and an isocyanate; a second layer coated on the first layer, the second layer including a plurality of microparticles; and a third layer coated on the second layer, the third layer including a cellulose based polymer.
10 . The device of claim 9 , wherein the isocyanate of the first layer is an aromatic isocyanate.
11 . The device of claim 9 , wherein the first layer further includes an acrylic polymer and a melamine formaldehyde polymer.
12 . The device of claim 9 , wherein the plurality of microparticles includes a polymeric gas/liquid containing microparticle.
13 . The device of claim 9 , wherein the third layer further includes a polyurethane.
14 . The device of claim 9 , wherein the third layer further includes a polyvinylpyrrolidone.
15 . The device of claim 9 , wherein the device is a needle, a vascular dilator, a guide wire, a stent, a biopsy site marker, a retrieval snare, a trocar, a hemostasis valve, or a brachytherapy seed.
16 . The device of claim 15 , wherein the needle is a disposable soft tissue biopsy needle, an aspiration needle, a bone marrow biopsy needle, a breast localization needle, an injection needle, a biopsy co-axial introducer needle, a bone biopsy needle, a guidewire introducer needle, an epidural needle, or a Huber needle.
17 . The device of claim 15 , wherein the device is a vascular retrieval snare.
18 . A method of coating a surface of a device, comprising forming a coating on the surface, wherein the coating includes an echogenic structure and a plurality of microparticles.
19 . The method of claim 18 , wherein forming the coating includes contacting the surface with a first coating solution including a first solvent, an ethylene acrylic acid copolymer and an isocyanate.
20 . The method of claim 19 , wherein forming the coating includes contacting the surface with a second coating solution including a second solvent and a plurality of microparticles.
21 . The method of claim 20 , wherein forming the coating includes contacting the surface with a third coating solution including a third solvent and a cellulose based polymer.
22 . The method of claim 21 , wherein the isocyanate of the first coating solution is an aromatic isocyanate.
23 . The method of claim 21 , wherein the first coating solution further includes an acrylic polymer and a melamine formaldehyde polymer.
24 . The method of claim 21 , wherein the plurality of microparticles includes a polymeric gas/liquid containing microparticle.
25 . The method of claim 21 , wherein the third coating solution further includes a polyurethane.
26 . The method of claim 21 , wherein the third coating solution further includes a polyvinylpyrrolidone.
27 . The method of claim 21 , wherein the device is a needle, a vascular dilator, a guide wire, a stent, a biopsy site marker, a retrieval snare, a trocar, a hemostasis valve, or a brachytherapy seed.
28 . The method of claim 27 , wherein the needle is a disposable soft tissue biopsy needle, an aspiration needle, a bone marrow biopsy needle, a breast localization needle, an injection needle, a biopsy co-axial introducer needle, a bone biopsy needle, a guidewire introducer needle, an epidural needle, or a Huber needle.
29 . The method of claim 27 , wherein the device is a vascular retrieval snare.
30 . A medical device comprising coating on a surface of the device, wherein the coating comprises a plurality of echogenic microparticles.
31 . The device of claim 30 , wherein the plurality of microparticles include a polymeric microparticle containing a gas or liquid.
32 . The device of claim 31 , wherein the polymeric microparticle comprises isopentane, isobutane, a fluorocarbon, air, nitrogen, carbon dioxide, argon, helium, or oxygen.
33 . The device of claim 30 , wherein the coating includes a first layer proximal to the surface of the device.
34 . The device of claim 33 , wherein the coating further includes a second layer coated on the first layer.
35 . The device of claim 34 , wherein the coating further includes a third layer coated on the second layer.
36 . The device of claim 30 , wherein the surface is stainless steel, a stainless steel alloy, nitinol, titanium, a titanium alloy, tantalum, aluminum, a cobalt-chromium alloy, a nickel-silver alloy, polyethylene, polypropylene, a fluoropolymer, a polyvinyl chloride, polyethylene terephthalate, polymethyl methacrylate, and silicone.
37 . The device of claim 30 , wherein the device is a needle, a vascular dilator, a guide wire, a stent, a biopsy site marker, a retrieval snare, a trocar, a hemostasis valve, catheters, or a brachytherapy seed.
38 . The device of claim 37 , wherein the catheter is a drainage catheter.
39 . The device of claim 37 , wherein the device is a vascular access needle.
40 . The device of claim 37 , wherein the device is a vascular retrieval snare.
41 . The device of claim 37 , wherein the needle is a soft tissue biopsy needle, an aspiration needle, a bone marrow biopsy needle, a breast localization needle, an injection needle, a biopsy co-axial introducer needle, a bone biopsy needle, a guidewire introducer needle, an epidural needle, or a Huber needle.
42 . The device of claim 37 , wherein the needle is disposable.
43 . The device of claim 33 , wherein the first layer comprises an isocyanate.
44 . The device of claim 43 , wherein the isocyanate is an aromatic isocyanate.
45 . The device of claim 33 , wherein the first layer comprises an acrylic polymer and a melamine formaldehyde polymer.
46 . The device of claim 33 , wherein the first layer comprises a vinyl acetate-acrylic copolymer and a formaldehyde copolymer.
47 . The device of claim 33 , wherein the first layer comprises an ethylene acrylic acid copolymer and an epoxy-bisphenol A copolymer.
48 . The device of claim 47 , wherein the first layer further comprises a polyurethane.
49 . The device of claim 48 , wherein the polyurethane is an aliphatic polycarbonate based polyurethane.
50 . The device of claim 34 , wherein the second layer comprises a cellulose based polymer.
51 . The device of claim 34 , wherein the second layer further comprises a polyurethane.
52 . The device of claim 34 , wherein the second layer further comprises a polyvinylpyrrolidone.
53 . The device of claim 34 , wherein the second layer further comprises a silicon based polymer.
54 . The device of claim 35 , wherein the third layer comprises a cellulose based polymer.
55 . The device of claim 35 , wherein the third layer further comprises a polyurethane.
56 . The device of claim 35 , wherein the third layer further comprises a polyvinylpyrrolidone.
57 . The device of claim 35 , wherein the third layer further comprises a silicone.
58 . The device of claim 34 , wherein the microparticles are substantially localized in the second layer.
59 . The device of claim 30 , wherein the coating is a lubricious coating.
60 . The device of claim 34 , wherein the first layer includes the microparticles and the second layer is lubricious.
61 . A composition comprising: a plurality of echogenic microparticles suspended in a first polymer matrix.
62 . The composition of claim 61 , wherein the first polymer matrix includes an ethylene acrylic acid copolymer, an isocyanate, a cellulose based polymer, an acrylic polymer, a melamine formaldehyde polymer, a polyurethane, or a polyvinylpyrrolidone.
63 . The composition of claim 61 , wherein the plurality of microparticles includes a polymeric gas/liquid containing microparticle.
64 . The composition of claim 61 , further comprising a solvent.
65 . The composition of claim 61 , wherein the first polymer matrix is coated on a second polymer matrix.