Adhesive-containing wound closure device and method
View Patent ↗An article, such as a tissue bonding article, includes a flexible material, a polymerization initiator or rate modifier disposed in or on the flexible material, and a polymerizable adhesive composition permeated throughout at least a portion of the flexible material, where the polymerization initiator or rate modifier is a polymerization initiator or rate modifier for the polymerizable adhesive composition.
1. A method of bonding tissue, comprising:
placing a flexible material over a tissue substrate, wherein a polymerization initiator or rate modifier is immobilized in or on said flexible material;
applying a polymerizable adhesive composition over and fully covering the flexible material;
allowing the polymerizable adhesive composition to permeate into and under the flexible material and polymerize to form a composite structure bonded to said tissue substrate; and
further comprising applying a polymerizable adhesive composition to said tissue substrate prior to placing said flexible material over said tissue substrate.
2. A method of bonding tissue, comprising:
placing a flexible material over a tissue substrate, wherein said tissue substrate is a section of tissue that includes a wound to be closed, wherein said flexible material fully covers said wound, and wherein a polymerization initiator or rate modifier is immobilized in or on said flexible material;
applying a polymerizable adhesive composition over and fully covering the flexible material; and
allowing the polymerizable adhesive composition to permeate into and under the flexible material and polymerize to form a composite structure bonded to said tissue substrate,
wherein the flexible material is elastic.
3. A method of bonding tissue, comprising:
placing a flexible material over a tissue substrate, wherein said tissue substrate is a section of tissue that includes a wound to be closed, wherein said flexible material fully covers said wound, and wherein a polymerization initiator or rate modifier is immobilized in or on said flexible material;
applying a polymerizable adhesive composition over and fully covering the flexible material; and
allowing the polymerizable adhesive composition to permeate into and under the flexible material and polymerize to form a composite structure bonded to said tissue substrate,
wherein the flexible material is memory retentive.
4. A method of bonding tissue, comprising:
placing a flexible material over a tissue substrate, wherein said tissue substrate is a section of tissue that includes a wound to be closed, wherein said flexible material fully covers said wound, and wherein a polymerization initiator or rate modifier is immobilized in or on said flexible material;
applying a polymerizable adhesive composition over and fully covering the flexible material; and
allowing the polymerizable adhesive composition to permeate into and under the flexible material and polymerize to form a composite structure bonded to said tissue substrate,
wherein the flexible material is placed over the wound in a lengthwise manner.
5. The method of claim 4 wherein the flexible material has a lengthwise configuration.
6. The method of claim 5 wherein the flexible material is in a configuration of a strip.