Mass spectrometer interface
View Patent ↗A mass spectrometer interface, having improved sensitivity and reduced chemical background, is disclosed. The mass spectrometer interface provides improved desolvation, chemical selectivity and ion transport. A flow of partially solvated ions is transported along a tortuous path into a region of disturbance of flow, where ions and neutral molecules collide and mix. Thermal energy is applied to the region of disturbance to promote liberation of at least some of the ionized particles from any attached impurities, thereby increasing the concentration of the ionized particles having the characteristic m/z ratios in the flow. Molecular reactions and low pressure ionization methods can also be performed for selective removal or enhancement of particular ions.
1. A method of providing ionized particles of a sample to a mass spectrometer, comprising:
providing a channel that guides ionized particles from an inlet to said mass spectrometer;
maintaining said channel below atmospheric pressure by a roughing pump in communication with said channel;
expanding a mixture of gas and said ionized particles from a source of high pressure into said inlet of said channel through a sampling orifice to increase the velocity of said mixture in said channel by way of gas expansion;
slowing said gas within said channel to provide a substantially laminar flow proximate an exit of said channel; and
providing said ionized particles proximate from said exit in said substantially laminar flow and into a downstream stage of said mass spectrometer, for analysis in said mass spectrometer.
2. The method of claim 1 , wherein said channel provides a tortuous path for said mixture of gas creating a region of disturbance for said gas within said channel maintaining a pressure in said channel between about 1 and 100 Torr.
3. The method of claim 1 , wherein said channel has a generally round cross-section proximate a region of disturbance, and flow of said gas becomes generally laminar within a distance equal to about twice said diameter from said region of disturbance.
4. The method of claim 1 , wherein said channel comprises a barrier to provide a tortuous flow within said channel.
5. The method of claim 3 , wherein said channel guides said gas around a bend having an angle of at least 20 degrees.
6. The method of claim 1 , further comprising colliding said ionized particles and attached impurities with a wall of said channel, so as to promote liberation of at least some of said ionized particles from said impurities.
7. The method of claim 6 , further comprising deflecting said ionized particles into said mass spectrometer using at least one electrode.
8. The method of claim 7 , wherein said deflecting comprises using at least one electrode upstream of said mass spectrometer to pulse said ionized particles, so as to facilitate separation of at least some of said ionized particles.
9. The method of claim 1 , wherein said gas proximate said exit is at a pressure in the range of 1-10 Torr.
10. The method of claim 1 , wherein said gas proximate said exit is in at a pressure in the range of 1-2 Torr.
11. An apparatus for providing ionized particles of a target sample to a mass spectrometer, said ionized particles having characteristic mass to charge (m/z) ratios, said apparatus comprising: a channel providing a guide path for guiding a flow of gas from an inlet to an outlet; an expansion orifice to expand a flow of gas into said channel thereby increasing the gas' velocity; a roughing pump to reduce pressure in said channel to below atmospheric pressure; geometry for slowing said flow of gas, said outlet being provided at proximate a channel section in which flow of said gas has been slowed to be generally laminar to sample ionized particles from said flow generally perpendicular to said flow.
12. The apparatus of claim 11 , wherein said channel has first, second and third sections with progressively larger diameters, said first section having a cross-sectional diameter of between 4-10 mm, said second section having a cross-section diameter of between 5-15 mm, said third section having a cross-section diameter of between 10-30 mm.
13. The apparatus of claim 12 , wherein said exit is in at least the third channel section downstream of said sample inlet.
14. The method of claim 1 , wherein said sampling occurs in a region proximate said exit having a pressure in the range of 1-10 Torr.
15. The method of claim 1 , further comprising introducing at least one of a) a reagent; b) a second mixture of ionized particles and attached impurities; or c) electrons, to interact with said ionized particles in said channel.
16. The apparatus of claim 11 , further comprising a source for providing at least one of a) a reagent; b) a second mixture of ionized particles and attached impurities; or c) electrons, to interact with said ionized particles into said channel.