Micro-chemical analysis device, microchemical measuring method, and sample collecting tool
View Patent ↗A micro-cassette 1 stores a sample, a reagent, and an additive, and comprises a sensor measures the component of measurement item. Analysis device 2 comprises liquid control unit controls each liquid in micro-cassette 1 . Mixing controller 33 mixes the sample and the additive sent to sample processing unit 13 , and generates the first sample includes a formed element. Isolation unit 14 generates the second sample from the first sample sent from sample processing unit 13 . Sensor 18 measures the compound liquid of the second sample and reagent, and generates the analysis signal.
1. A micro-chemical analysis device, comprising:
a detachable micro-cassette including a sample storage unit containing an original sample, a reagent storage unit containing a reagent, and an additive storage unit configured to store an additive; and
an analysis device configured to receive the detachable micro-cassette containing the original sample and the reagent, wherein
the analysis device includes
a liquid control unit configured to cause the original sample contained in the sample storage unit to be transferred to a sample processing unit of the micro-cassette through a sample channel, and to cause the additive stored in the additive storage unit to be transferred to the sample processing unit of the micro-cassette through an additive channel;
the micro-cassette includes
the sample processing unit configured to mix the additive to the original sample to form a waste component that negatively affects analysis of the original sample so as to obtain a first sample and the waste component, the mixing of the additive and the original sample being controlled by the liquid control unit of the analysis device; and
an isolation unit configured to separate the waste component from the first sample to produce an isolated second sample; and
the analysis device further includes
a data processing unit configured to produce analysis data indicative of a component of interest included in a mixture of the isolated second sample and the reagent.
2. The micro-chemical analysis device according to claim 1 , wherein the isolation unit comprises a filtration film disposed in the micro-cassette and configured to filter the sample.
3. The micro-chemical analysis device according to claim 1 , wherein the isolation unit comprises a centrifugal device disposed in the analysis device and configured to rotate the micro-cassette.
4. The micro-chemical analysis device according to claim 1 ,
wherein micro-cassette contains first and second reagents, and the data processing unit is configured to produce a first analysis data indicative of a first component of interest included in a mixture of the original sample and the first reagent and a second analysis data indicative of a second component of interest included in a mixture of the original sample and the second reagent.
5. The micro-chemical analysis device according to claim 1 , further comprising a main body including plural insertion parts configured to receive respective plural detachable micro-cassettes, wherein the data processing unit is configured to generate plural analysis data corresponding to plural components of interest produced in processing samples and reagents contained in the plural micro-cassettes inserted in the insertion parts.
6. The micro-chemical analysis device according to claim 1 , wherein the micro-cassette contains first and second original samples and first and second reagents, and the data processing unit is configured to produce first analysis data indicative of a first component of interest included in a mixture of the first original sample and the first reagent and second analysis data indicative of a second component of interest included in a mixture of the second original sample and the second reagent.
7. The micro-chemical analysis device according to claim 1 , wherein the original sample is blood contained by the micro-cassette, and the micro-cassette includes a measurement unit that measures a coagulation time of the blood or a blood count in the blood.
8. The micro-chemical analysis device according to claim 1 , wherein the data processing unit is configured to produce analysis data indicative of the component of interest, which is one of protein, carbohydrate, and fat contained in blood.
9. The micro-chemical analysis device of claim 1 , wherein the liquid control unit is configured to cause the first sample to be sent from the sample processing unit to the isolation unit, to dispense the second sample from the isolation unit to a reaction unit, to cause the reagent contained in the reagent storage unit to be sent to the reaction unit, and to cause the reagent and the second sample to be mixed in the reaction unit.
10. The micro-chemical analysis device of claim 1 , wherein the liquid control unit comprises:
a mixing controller configured to cause the reagent and the second sample to be mixed in a reaction unit to form a compound liquid.
11. The micro-chemical analysis device of claim 10 , wherein the liquid control unit comprises:
a temperature controller configured to maintain the compound liquid in the reaction unit at a predefined temperature.
12. The micro-chemical analysis device of claim 1 , wherein the liquid control unit is further configured to cause the additive to be transferred to the sample processing unit in synchronization with a transferring motion of the sample.