Busulfan immunoassay

1. An antibody which binds selectively to busulfan and does not have any substantial cross-reactivity to tetramethylene sulfone, tetrahydrothiophene and tetrahydrothiophene-3-ol-1,1-dioxide.

2. The antibody of claim 1 , wherein said antibody is derived from mice, rabbits or rats.

3. The antibody of claim 1 , wherein said antibody is a monoclonal antibody.

4. The antibody of claim 2 , wherein said antibody is a monoclonal antibody.

5. The antibody of claim 1 , wherein said antibody is derived from an immunogen of a polyamine polymer with a compound selected from the group consisting of compounds of the formula:

wherein A is lower alkylene;

X′ is a functional linking group;

Y is an organic spacing group;

X is a terminal functional group capable of binding to a polyamine polymer;

p and z are independent integers of from 0 to 1;

or a compound of the formula

wherein A′ is lower alkylene or lower alkenylene;

X′, Y, X, p and z are as above

or mixtures thereof.

6. The antibody of claim 5 , wherein said antibody is derived from mice, rabbits or rats.

7. The antibody of claim 5 , wherein said antibody is a monoclonal antibody.

8. The antibody of claim 6 , wherein said antibody is a monoclonal antibody.

9. The antibody of claim 5 , wherein said compound is

wherein A, X′, Y, X, p and z are as above.

10. The antibody of claim 9 wherein said wherein X is

and R 3 is hydrogen or taken together with its attached oxygen chain forms a reactive ester.

11. The antibody of claim 10 , wherein z is 0 and p is 1.

12. The antibody of claim 11 , wherein A is —(CH 2 ) v — and v is 1 or 2.

13. The antibody of claim 12 , wherein v is 2.

14. The antibody of claim 5 , wherein said compound is

wherein A′, X′, Y, X and z are as above.

15. The antibody of claim 14 , wherein X is

and R 3 is hydrogen or taken together with its attached oxygen chain form a reactive ester.