Assessing neural survival
View Patent ↗Neural survival related to a cochlear implant may be assessed by determining stimulus efficacy for both focused and unfocused stimulation at a plurality of locations adjacent nerve tissue; and comparing stimulus efficacy for both the focused and unfocused stimulation at a plurality of locations to determine a measure of neural survival. In particular small differences in effects produced by unfocused and focused stimulation at each of the locations tends to indicate good survival at those locations and conversely large differences in effects of focused and unfocused stimulation at a given location indicate poor survival at that location.
1. A method for assessing neural survival in a region encompassing a cochlear implant and adjacent nerve tissue, said method comprising:
applying, as electrical test stimulation, focused and unfocused stimulation at a location in said region, respectively;
determining stimulus efficacy for said focused and unfocused stimulation relative to said location, respectively; and
comparing said stimulus efficacies of said focused and unfocused stimulation to determine a measure of neural survival local to said location.
2. The method as recited in claim 1 , wherein:
said stimulus efficacy is based on a perceptual threshold; and
said comparing includes determining a difference between perceptual thresholds for focused and unfocused stimulation relative to said location.
3. The method as recited in claim 2 , wherein said focused stimulation includes stimulation which relies on constructive and destructive interference across fields from energized electrodes of said cochlear implant.
4. The method as recited in claim 3 , wherein said focused stimulation employs a phased array wherein all electrodes of said cochlear implant are energized.
5. The method as recited in claim 2 , further comprising:
determining whether to correct said perceptual thresholds for modiolar proximity of electrodes of said cochlear implant.
6. The method as recited in claim 5 , wherein:
said determining whether to correct is based upon a correlation between a peak transimpedance and said unfocused perceptual threshold.
7. The method as recited in claim 5 , further comprising:
correcting for modiolar proximity based on peak transimpedance.
8. The method as recited in claim 5 , wherein:
said determining whether to correct is based upon imaging said region or a portion of said region.
9. The method as recited in claim 8 , wherein said imaging comprises computed tomography.
10. The method as recited in claim 1 , wherein said stimulus efficacy is based on minimum current to produce an evoked potential.
11. The method as recited in claim 10 , wherein said evoked potential is an auditory nerve compound action potential.
12. The method as recited in claim 10 , wherein said evoked potential is an electrical auditory brainstem response.
13. The method as recited in claim 1 , wherein said stimulus efficacy is determined based on a voltage derived from fluid adjacent an electrode of said cochlear implant that is a primary point of current injection.
14. The method as recited in claim 1 , wherein said stimulus efficacy is based upon perception of loudness at a given current level.
15. The method as recited in claim 1 , wherein said stimulus efficacy is based upon evoked potential magnitude at a given current level.
16. The method as recited in claim 1 , wherein said location is an electrode of said cochlear implant that is a primary point of current injection for said focused and unfocused stimulation.
17. A method for assessing neural survival in a region encompassing a cochlear implant and adjacent nerve tissue, said method comprising:
applying focused and unfocused stimulation at a location in said region, respectively;
determining, relative to said location, one or more metrics for said focused and unfocused stimulation, respectively, the one or more metrics including at least one of:
a response threshold;
a minimum current to produce an evoked potential;
a voltage level in adjacent fluid; and
a magnitude of an evoked potential; and
comparing corresponding said one or more metrics for said focused and unfocused stimulation to determine a measure of neural survival local to said location.