Devices for the Treatment of Vascular Aneurysm
Devices for the treatment of vascular aneurysms are described. The treatment is achieved through the delivery of an effective amount of elastin stabilization agent to an isolated volume at the aneurysm. The elastin stabilization agent maybe embedded in a delivery composition. The device optionally has an aspiration means to improve the effectiveness of the treatment.
1 . A device for treating an isolated volume in a blood vessel, the device comprising:
a shaft comprising a proximal end, a distal end and at least one lumen extending from at or near the proximal end to at or near the distal end, wherein the lumen connects with a port at its proximal end; and
a sealing element comprising an extendable element and a fluid exchange portion comprising one or more exchange ports in fluid communication with the lumen of the shaft,
wherein the extendable element has a lower profile configuration and an extended configuration having a shape that pushes against the wall of the vessel to form the isolated volume within the vessel with the exchange port of the fluid exchange portion configured for the exchange of fluid between the isolated volume and the lumen, and
wherein the sealing element in the extended configuration comprises a channel to allow blood flow past the isolated volume when the extendable element contacts the vessel wall.
2 . (canceled)
3 . The device of claim 1 wherein the shaft further comprises a rapid exchange guidewire lumen with a port at the distal end of the shaft.
4 . The device of claim 1 wherein the extendable element comprises a balloon that is inflated in the extended configuration and deflated in the lower profile configuration and wherein the balloon is in fluid communication with one of the lumens of the shaft.
5 . The device of claim 1 wherein the extendable element comprises a fluid impenneable membrane and a self-extending support interfaced with the membrane wherein the self-extending support transitions the extendable element between the lower profile configuration and the extended configuration when the support is unconstrained.
6 . The device of claim 1 wherein the extendable element comprises an actuation element that controls the transition of the extendable element between the lower profile configuration and the extended configuration.
7 . The device of claim 1 wherein the fluid exchange portion is on the shaft of the device comprising one or more exchange ports in fluid communication with the isolated volume.
8 . The device of claim 7 wherein the exchange port further comprises a tubular conduit displaced from the shaft having an opening that is in fluid communication with the isolated volume.
9 . The device of claim 7 wherein the fluid exchange portion comprises a side channel that is a portion of the lumen having an opening on the side of the sealing element of the device.
10 . The device of claim 9 further comprises a micro-catheter placed inside the side channel and the lumen to go through the opening on the side of the sealing element to access the isolated volume.
11 . The device of claim 1 wherein the exchange ports comprises a liquid permeable structure.
12 . The device of claim 1 further comprises an aspiration apparatus operably connected to the port to one of the lumens of the shaft.
13 . The device of claim 12 wherein the aspiration apparatus comprises a syringe.
14 . The device of claim 1 further comprising a delivery element operably connected to the port to one of the lumens of the shaft wherein the delivery element comprises a stabilizing liquid that reacts with vessel tissue to stabilize the tissue.
15 - 30 . (canceled)