5-pyridinone substituted indazoles

1. A compound of formula I:

wherein

n is 0 or 1;

R is an optionally substituted pyrrolidin-1-yl;

R 3 and R 4 are each independently H or alkyl;

B is selected from aryl, and cycloalkyl;

R 5 , R 6 , R 7 are each independently selected from H, —OH, —O-alkyl, alkyl, halo, —CF 3 , —CN, and —O-aryl; and

R 14 is H or —OH;

wherein optional substituents are selected from the group consisting of alkyl, halogen, haloalkyl, hydroxy, lower alkoxy, carboxy, carboalkoxy, carboxamido, cyano, carbonyl, nitro, amino, alkylamino, dialkylamino, mercapto, alkylthio, sulfoxide, sulfone, acylamino, amidino, phenyl, benzyl, heteroaryl, phenoxy, benzyloxy, and heteroaryloxy; and

provided that when n is 0, R 3 and R 4 are H and R is pyrrolidin-1-yl, then

when B is phenyl which is substituted at the 2-position by methoxy or at the 3-position by methyl, there is at least one additional substituent on the phenyl ring;

or pharmaceutically acceptable salt thereof.

2. A compound according to claim 1 , wherein R is selected from the group consisting of pyrrolidin-1-yl, 3-hydroxypyrrolidin-1-yl, and 3-hydroxymethylpyrrolidin-1-yl.

3. A compound according to claim 1 , wherein R is selected from S-3-hydroxypyrrolidin-1-yl, R-3-hydroxypyrrolidin-1-yl, S-3-hydroxymethylpyrrolidin-1-yl, and R-3-hydroxymethylpyrrolidin-1-yl.

4. A compound according to claim 3 , wherein R 3 and R 4 are both H.

5. A compound according to claim 1 , wherein B, taken together with R 5 , R 6 and R 7 , is 4-trifluoromethylphenyl and n is 1.

6. A compound according to claim 5 , wherein R 14 is —OH.

7. A compound according to claim 1 , wherein n is 0.

8. A compound according to claim 1 , wherein n is 1.

9. A compound according to claim 1 , wherein B is phenyl.

10. A compound according to claim 9 , wherein B, taken together with R 5 , R 6 and R 7 , is selected from the group consisting of phenyl, 4-chlorophenyl, 4-fluorophenyl, 3-chlorophenyl, 3-phenoxyphenyl, 4-trifluoromethylphenyl, 3-trifluoromethylphenyl, 2,4-dichlorophenyl, 4-methylphenyl, 4-trifluoromethoxyphenyl, 4-cyanophenyl, 4-methoxyphenyl, 2-cyano-4-fluorophenyl, 2,4-dimethoxyphenyl, 2,4-difluorophenyl, 4-isopropoxyphenyl, 2,4-di-trifluoromethylphenyl, 4-n-butoxy-2-methylphenyl, 2-methylphenyl, 4-benzyloxy-2-methylphenyl, 4-chloro-2-methoxyphenyl, 4 methoxy-2-methylphenyl, 2-chloro-4-trifluoromethylphenyl, 4-chloro-2-fluorophenyl, 4-trifluoromethyl-2-fluorophenyl, 4-methoxy-2-fluorophenyl, 4-methoxy-2-chlorophenyl, 4-ethoxyphenyl, 4-trifluoromethoxy-2-fluorophenyl, and 4-trifluoromethoxy-2-methylphenyl.

11. A compound according to claim 1 , wherein B, taken together with R 5 , R 6 and R 7 , is selected from napthalen-1-yl and naphthalen-2-yl.

12. A compound according to claim 1 , wherein B, taken together with R 5 , R 6 and R 7 , is selected from 4-methylcyclohex-1-enyl.

13. A compound according to claim 1 , wherein B, taken together with R 5 , R 6 and R 7 , is selected from 4-methylcyclohex-1-yl.

14. A compound according to claim 1 , wherein the compound is selected from the group consisting of:

15. A compound according to claim 14 , which is a pharmaceutically acceptable salt thereof.

16. A compound according to claim 1 , wherein the compound is selected from the group consisting of:

17. A compound according to claim 16 , which is a pharmaceutically acceptable salt thereof.

18. A compound according to claim 1 , wherein the compound is selected from the group consisting of:

19. A compound according to claim 18 , which is a pharmaceutically acceptable salt thereof.

20. A compound according to claim 1 , wherein the compound is selected from the group consisting of:

21. A compound according to claim 20 , which is a pharmaceutically acceptable salt thereof.

22. A pharmaceutical composition comprising a compound according to claim 1 and a pharmaceutically acceptable carrier, excipient or diluent therefor.