OPHTHALMIC COMPOSITIONS COMPRISING A TERPENE COMPOUND
An aqueous ophthalmic composition comprising one or more terpene compounds, and one or more natural polymers selected from the group comprising hyaluronic acid, condroitin sulfate, alginate, guar gum, fructan, arabinogalactan or any corresponding salt or derivative of each thereof. The compositions can be used to disinfect or package a contact lens, or as an eye drop to comfort irritated eyes or rewet a contact lens.
1 . An aqueous ophthalmic composition comprising:
one or more natural polymers selected from the group comprising hyaluronic acid, condroitin sulfate, alginate, guar gum, fructan and arabinogalactan or any corresponding salt or derivative of each thereof, and
one or more terpene compounds, wherein the ophthalmic composition has an osmolality in a range from 200 mOsmol/kg to 400 mOsmol/kg.
2 . The composition of claim 2 further comprising polymeric hexamethylene biguanide, which is present from 0.2 ppm to 0.8 ppm, α-[4-tris(2-hydroxyethyl) ammonium chloride-2-butenyl]poly[1-dimethylammonium chloride-2-butenyl]-ω-tris(2-hydroxyethyl) ammonium chloride, which is present from 1 ppm to 5 ppm, or any one mixture thereof.
3 . The composition of claim 1 wherein the natural polymers are selected from the group consisting of hyaluronic acid, alginate and arabinogalactan.
4 . The composition of claim 4 wherein the terpene compounds are selected from the group consisting of α-terpineol, 1-terpinen-4-ol, menthol, eugenol and geraniol.
5 . The composition of claim 1 further comprising dexpanthenol, sorbitol, xylitol or any one mixture thereof.
6 . The composition of claim 1 further comprising a compound of formula I
wherein R 1 is R or —(CH 2 ) n —NHC(O)R, wherein R is a C 8 -C 24 alkyl optionally substituted with hydroxyl and n is 2, 3 or 4; R 2 and R 3 are each independently selected from the group consisting of hydrogen and C 1 -C 4 alkyl; R 4 is a C 2 -C 6 alkylene optionally substituted with hydroxyl; and Y is CO 2 − or SO 3 − .
7 . The composition of claim 6 wherein R 1 is decyl, and R 2 and R 3 are methyl, and Z is —SO 3 − .
8 . The composition of claim 1 wherein the natural polymers are selected from hydroxypropyl guar or carboxyl-modified fructan.
9 . The composition of claim 1 further comprising allantoin.
10 . An aqueous ophthalmic composition comprising:
one or more natural polymers selected from the group comprising hyaluronic acid, hydroxypropyl guar and alginate or any corresponding salt or derivative of each thereof;
one or more terpene compounds; and
a sugar alcohol, wherein the ophthalmic composition has an osmolality in a range from 200 mOsmol/kg to 400 mOsmol/kg.
11 . The composition of claim 10 further comprising a compound of formula I
wherein R 1 is R or —(CH 2 ) n —NHC(O)R, wherein R is a C 8 -C 30 alkyl optionally substituted with hydroxyl and n is 2, 3 or 4; R 2 and R 3 are each independently selected from the group consisting of hydrogen and C 1 -C 4 alkyl; R 4 is a C 2 -C 8 alkylene optionally substituted with hydroxyl; and Y is CO 2 − or SO 3 − ,
12 . The composition of claim 10 wherein the natural polymers are selected from hyaluronic acid or alginate.
13 . The composition of claim 10 wherein the natural polymers are selected from hydroxypropyl guar or carboxyl-modified fructan.
14 . The composition of claim 10 wherein the terpene compounds are selected from the group consisting of α-terpineol, 1-terpinen-4-ol, menthol, eugenol and geraniol.
15 . The composition of claim 10 wherein the sugar alcohol is selected from dexpanthenol, sorbitol, xylitol or any one mixture thereof.
16 . The composition of claim 10 further comprising allantoin.
17 . The use of the ophthalmic composition of claim 1 in an eye care or a contact lens care product selected from the group consisting of eye drops, contact lens packaging solution and contact lens multi-purpose solution.
18 . The use of the ophthalmic composition of claim 10 in an eye care or a contact lens care product selected from the group consisting of eye drops, contact lens packaging solution and contact lens multi-purpose solution.