IP Library › Granted Patent US 8,030,325
Granted Patent B2
US 8,030,325 · App. 12/179,708 · Granted Oct 4, 2011

Biosynthetic gene cluster for the production of a complex polyketide

View Patent ↗
Loading inventors, assignments & file history…
Monitor This Case
Get email alerts when status or documents change.
Order Certified Copies
Most orders are placed with the USPTO same day — all within 24 business hours.
Order via The Patent Place →
Pre-filled with this patent's details
Quick Facts
Patent No.
US 8,030,325
App. No.
12/179,708
Granted
Oct 4, 2011
Kind
B2
Abstract

A polyketide synthase complex composed of polyketide synthase with 15 total modules, a non-ribosomal peptide synthetase with 1 module, and a cytochrome P450 hydroxylase is described. Also provided are novel Streptomyces species and methods of modified Streptomyces species. Further described are novel compounds, 36-ketomeridamycin, C9-deoxomeridamycin, and C9-deoxoprolylmeridamcyin and uses thereof.

Claims (2)

1. A C36-keto meridamycin, or a pharmaceutically acceptable salt thereof, having the structure:

2. A pharmaceutical composition comprising a pharmaceutically acceptable carrier and the compound of claim 1 .