OPHTHALMIC COMPOSITIONS COMPRISING A CARBOXYL-MODIFIED FRUCTAN OR A SALT THEREOF
Ophthalmic composition including a carboxyl-modified fructan or a salt thereof. The ophthalmic composition can be used in an eye care product or a contact lens care product such as a contact lens packaging solution or contact lens disinfecting solution.
1 . An ophthalmic composition comprising a carboxyl-modified fructan or a salt thereof, wherein the ophthalmic composition has an osmolality in a range from 200 mOsmol/kg to 400 mOsmol/kg.
2 . The composition of claim 1 further comprising a cationic antimicrobial component selected from the group consisting of α-[4-tris(2-hydroxyethyl)ammonium chloride-2-butenyl]poly[1-dimethylammonium chloride-2-butenyl]-ω-tris(2-hydroxyethyl)ammonium chloride, benzalkonium halides, alexidine and salts thereof, hexamethylene biguanides and salts thereof and their polymers, and mixtures thereof.
3 . The composition of claim 2 wherein the cationic antimicrobial component is selected from the group consisting of poly(hexamethylene biguanide), which is present from 0.2 ppm to 2 ppm, α-[4-tris(2-hydroxyethyl)ammonium chloride-2-butenyl]poly[1-dimethylammonium chloride-2-butenyl]-ω-tris(2-hydroxyethyl) ammonium chloride, which is present from 2 ppm to 15 ppm, and any mixture thereof.
4 . The composition of claim 1 wherein the carboxyl-modified fructan or the salt thereof is a carboxyalkylinulin or a salt thereof.
5 . The composition of claim 4 wherein the carboxyalkylinulin is selected from the group consisting of carboxymethylinulin, carboxyethylinulin or a salt of each thereof.
6 . The composition of claim 4 wherein the carboxyl-modified fructan includes 0.3 to 3 carboxylgroups per anhydrofructose unit.
7 . The composition of claim 5 wherein the carboxyalkylinulin includes 0.3 to 3 carboxylgroups per anhydrofructose unit.
8 . The composition of claim 7 further comprising a cationic antimicrobial component selected from the group consisting of poly(hexamethylene biguanide), which is present from 0.2 ppm to 2 ppm, α-[4-tris(2-hydroxyethyl)ammonium chloride-2-butenyl]poly[1-dimethylammonium chloride-2-butenyl]-ω-tris(2-hydroxyethyl) ammonium chloride, which is present from 2 ppm to 15 ppm, and any mixture thereof.
9 . The composition of claim 1 further comprising one or more biopolymers and any derivative thereof selected from the group consisting of hyaluronic acid and alginate.
11 . The composition of claim 1 further comprising dexpanthenol, sorbitol or any mixture thereof.
12 . The composition of claim 1 further comprising hydroxypropylmethyl cellulose, propylene glycol or hydroxypropyl guar.
13 . The composition of claim 1 further comprising a betaine or a sulphobetaine surfactant of formula I
wherein R 1 is R or —(CH 2 ) n —NHC(O)R, wherein R is a C 8 -C 30 alkyl optionally substituted with hydroxyl and n is 2, 3 or 4; R 2 and R 3 are each independently selected from the group consisting of hydrogen and C 1 -C 4 alkyl; R 4 is a C 2 -C 8 alkylene optionally substituted with hydroxyl; and Y is CO 2 − or SO 3 − .
14 . The composition of claim 13 wherein R 1 is R; R 2 and R 3 are each independently selected from a C 1 -C 2 alkyl; R 4 is a C 2 -C 4 alkylene and Y is SO 3 − .
15 . The use of the ophthalmic composition of claim 1 in an eye care product, or a contact lens care product selected from the group consisting of contact lens rewet drops, contact lens packaging solution and contact lens disinfecting solution.