COMPOSITION CONTAINING SEVERAL BOTULIC TOXINS
The invention concerns a composition including at least one botulinum neurotoxin type A1, and one botulinum neurotoxin type A the amino acid sequence of which as at least 5% difference with the amino acid sequence of botulinum neurotoxin type A1.
1 . A composition comprising at least:
one botulinum neurotoxin type A1, and
one botulinum neurotoxin type A, the amino acid sequence of which exhibits at least 5% difference from the amino acid sequence of the botulinum neurotoxin type A1.
2 . The composition according to claim 1 , wherein the composition comprises at least one botulinum neurotoxin type A, the amino acid sequence of which exhibits at least 10% difference from the amino acid sequence of the botulinum neurotoxin type A1.
3 . The composition according to claim 1 , wherein the composition comprises at least
one botulinum neurotoxin type A1, and
one botulinum neurotoxin type A2.
4 . The composition according to claim 1 , wherein the composition comprises at least
one botulinum neurotoxin type A1, and
one botulinum neurotoxin type A2 isolated from the strain Clostridium botulinum NCTC9837.
5 . The composition according to claim 1 , wherein the composition comprises at least one analgesic agent.
6 . The composition according to claim 1 , wherein the composition comprises at least one polysaccharide.
7 . The composition according to claim 6 , wherein the polysaccharide is 2-hydroxyethyl starch.
8 . The composition according to claim 1 , wherein the composition comprises at least one cationic, anionic or non-ionic surfactant.
9 . The composition according to claim 1 , wherein the composition comprises at least one polysorbate non-ionic surfactant.
10 . The composition according to claim 1 , wherein the composition comprises at least one surfactant.
11 . The composition according to claim 1 , wherein the composition comprises at least one vasoconstrictor.
12 . A medicament composition comprising the composition according to claim 1 .
13 . A method of treatment of muscular disorders, neuromuscular disorders, neurological disorders, orthopaedic disorders, ophthalmological disorders, articular pathologies, endocrine disorders or urological disorders comprising administering the composition of claim 1 in a therapeutically effective quantity for treating such disorder to a patient suffering from a disorder comprising.
14 . A method of treatment of torticollis, spasmodic torticollis, local disorders of spasticity of the upper and/or lower limbs, pain, muscle pain, pain due to muscle spasms, myofascial pain, post-operative pain, muscle spasms, hemifacial spasm, blepharospasm, strabismus, facial asymmetry, muscle dystonia, cerebral paralysis, headaches, migraine, fibromyalgia, myalgia, hyperhidrosis, bromhidrosis, coxarthrosis, arthrosis of the hip, epicondylitis of the elbow, arthritis, rheumatoid arthritis, dyskinesias, achalasia, Oddi's sphincter dysfunctions, pancreatitis, gout, anal fissures, constipation, anismus, spasms of the pyloric valve, spastic bladder, spasms of the bladder, urinary incontinence, urine retention, prostatic hyperplasia, endometriosis, psoriasis, rhinitis, allergic rhinitis, obesity, hyperlacrimation, bone fractures, tendon lacerations or rotator muscle cap pathology of the shoulder comprising administering the composition of claim 1 in a therapeutically effective quantity for treating such disorder to a patient suffering from a disorder comprising.
15 . A method of cosmetic treatment comprising administering the composition of claim 1 to a patent desiring such treatment.
16 . A method of treating facial frown lines, facial wrinkles, wrinkles of the skin, wrinkles of the contour of the eye, glabellar frown lines, baldness, acne, excessive perspiration or hair loss comprising administering the composition of claim 1 in an amount effective to treat such condition.
17 . A method of treating blepharospasm comprising administering the composition of claim 1 in a therapeutically effective quantity for treatment of blepharospasm.
18 . A method of treating spasmodic torticollis comprising administering the composition of claim 1 in a therapeutically effective quantity for treatment of spasmodic torticollis.
19 . A method of cosmetic treatment comprising administering the composition of claim 4 to a patent desiring such treatment.
20 . A method of treating facial frown lines, facial wrinkles, wrinkles of the skin, wrinkles of the contour of the eye, glabellar frown lines, baldness, acne, excessive perspiration or hair loss comprising administering the composition of claim 4 to a patent in an amount effective to treat such condition.
21 . A method of treating blepharospasm comprising administering to a patient the composition of claim 4 in a therapeutically effective quantity for treatment of blepharospasm.
22 . A method of treating spasmodic torticollis comprising administering to a patient the composition of claim 4 in a therapeutically effective quantity for treatment of spasmodic torticollis.
23 . The composition of claim 10 , wherein said surfactant is polysorbate 80.
24 . The medicament of claim 12 , wherein the composition is an aqueous solution.