Pharmaceutical compositions of adsorbates of amorphous drug
View Patent ↗Pharmaceutical compositions comprise a low-solubility drug adsorbed onto a high surface area substrate to form an adsorbate. The compositions in some embodiments include a concentration-enhancing polymer.
1. A method for forming a pharmaceutical composition, comprising:
(a) providing a substrate having a surface area of at least 20 m 2 /g; wherein said substrate is selected from the group consisting of SiO 2 , TiO 2 , Al 2 O 3 , and zeolites,
(b) adding said substrate to a solvent to form a suspension and agitating said suspension;
(c) dissolving a low-solubility drug in said solvent; said low-solubility drug having a minimum aqueous solubility of less than 0.1 mg/ml at a pH of 1 to 8 and
(d) rapidly removing said solvent from said suspension to form an adsorbate comprising said low-solubility drug adsorbed onto said substrate,
wherein said solvent is rapidly removed so as to solidify said adsorbate within 100 seconds and wherein at least 80 wt % of said drug in said adsorbate is in amorphous form wherein said step of removing said solvent from said suspension is accomplished by spray-drying said suspension.
2. The method of claim 1 further comprising the step of adding a concentration-enhancing polymer to said suspension.
3. The method of claim 1 wherein said step of agitating comprises sonicating said suspension.
4. A method for forming a pharmaceutical composition, comprising:
(a) providing a substrate having a surface area of at least 20 m 2 /g; wherein said substrate is selected from the group consisting of SiO 2 , TiO 2 , Al 2 O 3 , and zeolites,
(b) adding said substrate to a solvent to form a suspension and agitating said suspension;
(c) dissolving a low-solubility drug in said solvent; said low-solubility drug having a minimum aqueous solubility of less than 0.1 mg/ml at a pH of 1 to 8;
(d) dissolving a concentration-enhancing polymer in said solvent; and
(e) rapidly removing said solvent from said suspension to form an adsorbate comprising said low-solubility drug adsorbed onto said substrate,
wherein said solvent is rapidly removed so as to solidify said adsorbate within 100 seconds and wherein at least 80 wt % of said drug in said adsorbate is in amorphous form wherein said step of removing said solvent from said suspension is accomplished by spray-drying said suspension.
5. The method of any of claim 1 or 4 wherein said concentration enhancing polymer is selected from a vinyl polymer or copolymer having at least one substituent selected from the group consisting of hydroxyl, alkylacyloxy, and cyclicamido, vinyl copolymers of at least one hydrophilic, hydroxyl-containing repeat unit and at least one hydrophobic, alkyl- or aryl-containing repeat unit, polyvinyl alcohols that have at least a portion of their repeat units in the unhydrolyzed form, polyvinyl alcohol polyvinyl acetate copolymers, polyethylene glycol polypropylene glycol copolymers, polyvinyl pyrrolidone, polyethylene polyvinyl alcohol copolymers, polyoxyethylene-polyoxypropylene block copolymers, and blends thereof.
6. The method of any of claim 1 or 4 wherein said concentration enhancing polymer is selected from hydroxypropyl methyl cellulose acetate, hydroxypropyl methyl cellulose, hydroxypropyl cellulose, methyl cellulose, hydroxyethyl methyl cellulose, hydroxyethyl cellulose acetate, and hydroxyethyl ethyl cellulose, and blends thereof.
7. The method of claim 6 wherein said step of agitating comprises sonicating said suspension.