Conductive therapeutic coating for medical device
View Patent ↗An implantable medical device includes a housing and a coating disposed on the housing. The coating includes a conductive carrier and a therapeutic agent, e.g. an anti-infective agent such as silver particles. The conductive carrier can be any suitable conductive material, such as iridium oxide, titanium nitride, diamond-like carbon, graphite, polyaniline, platinum, carbon nanotubes, carbon black, platinum black, or poly 3,4,-ethylenedioxythiophene. Coatings containing iridium oxide and metallic silver particles are effective in inhibiting bacterial growth in vitro.
1. An implantable medical device comprising:
a metallic housing;
a coating disposed on the housing; the coating consist of a conductive carrier and a metallic anti-infective agent, wherein the conductive carrier is iridium oxide and the metallic anti-infective agent is silver nanoparticles.
2. The device of claim 1 , wherein the coating comprises a first layer in contact with the housing and a second layer in contact with the first layer, wherein the metallic anti-infective agent is disposed in the first layer and the conductive carrier is disposed in the second layer.
3. The device of claim 1 , wherein the coating comprises a first layer in contact with the housing and a second layer in contact with the first layer, wherein the metallic anti-infective agent is disposed in the second layer and the conductive carrier is disposed in the first layer.
4. The device of claim 1 , wherein the housing serves as a return electrode.
5. The device of claim 1 , wherein the device is an active implantable medical device.
6. A system comprising:
the device of claim 5 ; and
an associated medical lead operably coupleable to the device.
7. A method for producing an implantable medical device having a conductive therapeutic coating; the method comprising:
depositing silver nanoparticles on the metallic device housing of the device; and
depositing iridium oxide on the silver nanoparticles.
8. The method of claim 7 , wherein depositing the silver nanoparticles on the device comprises depositing the therapeutic agent by plasma vapor deposition or chemical vapor deposition.
9. A method for producing an implantable medical device having a conductive therapeutic coating; the method comprising:
depositing iridium oxide on the metallic housing of the device; and
depositing a silver nanoparticles on the iridium oxide.
10. An implantable medical device comprising:
a metallic housing;
a coating disposed on the housing; the coating consist of a conductive carrier and an a therapeutic agent, wherein the conductive carrier is iridium oxide and the therapeutic agent is silver nanoparticles,
wherein the coating has a conductance sufficient to allow conduction between the housing and tissue of a patient when the device is implanted in a patient.
11. The implantable medical device of claim 1 , wherein the device is an electrical signal generator.
12. The implantable medical device of claim 1 , wherein the device is selected from the group consisting of a defibrillator, a pacemaker, and a neurostimulator.
13. The implantable medical device of claim 10 , wherein the device is an active implantable medical device.
14. The implantable medical device of claim 10 , wherein the device is an electrical signal generator.
15. The implantable medical device of claim 10 , wherein the device is selected from the group consisting of a defibrillator, a pacemaker, and a neurostimulator.