Method and system for biopsy and analysis of a body tissue
Methods and systems for performing biopsies and diagnosing tumors and suspect masses within the body. A biopsy sample is frozen while still in the body of a patient, then removed from the patient, stored frozen, and subject to IHC, microarray or other analysis to determine the amount, type or presence of signaling substances within the tumor or suspect mass.
1 . A method for diagnosing and treating breast tumors comprising:
freezing a biopsy sample within a breast tumor;
excising the frozen biopsy sample from the breast tumor after freezing;
testing the biopsy sample for the presence of a signaling substance which indicates the susceptibility of the breast tumor to a course of treatment;
diagnosing the tumor based on the presence of the signaling substance within the biopsy sample.
2 . The method of claim 1 , wherein the testing comprises:
testing the biopsy sample with a microarray to determine the amount of mRNA in the biopsy sample.
3 . The method of claim 1 , wherein the testing comprises:
testing the biopsy sample with a microarray to determine the type of mRNA in the biopsy sample.
4 . The method of claim 1 , wherein the testing comprises:
testing the biopsy sample with a microarray to determine the presence or amount of mutant mRNA in the biopsy sample.
5 . The method of claim 1 , wherein the testing comprises:
testing the biopsy sample with a microarray to determine the amount of HER-2/Neu in the biopsy sample.
6 . The method of claim 1 , wherein the testing comprises:
testing the biopsy sample with a microarray to determine the amount of HER-1 in the biopsy sample.
7 . The method of claim 1 , wherein the testing comprises:
testing the biopsy sample with a microarray to determine the amount of ERBB2 in the biopsy sample.
8 . The method of claim 1 , wherein the testing comprises:
testing the biopsy sample with a microarray to determine the amount of vascular endothelial growth factor receptor (VEGFR) in the biopsy sample.