IP Library Granted Patent US 7,728,051
Granted Patent B2
US 7,728,051 · App. 12/187,495 · Granted Jun 1, 2010

Ophthalmic lens materials containing chromophores that absorb both UV and short wavelength visible light

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Quick Facts
Patent No.
US 7,728,051
App. No.
12/187,495
Granted
Jun 1, 2010
Kind
B2
Abstract

Chromophores that absorb both UV and short wavelength visible light are disclosed. The chromophores are particularly suitable for use in intraocular lens materials.

Claims (51)

1. A chromophore of the formula

wherein

A=H or CH 3 ;

X=O or NH;

n=2-6;

m=0-6; and

R=H, C 1 -C 4 alkyl, or C 1 -C 4 alkoxy.

2. The chromophore of claim 1 wherein

A=CH 3 ;

X=NH;

n=2;

m=0; and

R=CH 3 .

3. An ophthalmic device material comprising the chromophore of claim 1 and a device-forming monomer selected from the group consisting of acrylic monomers and silicone-containing monomers.

4. The ophthalmic device material of claim 3 wherein the ophthalmic device material comprises from 0.1 to 5% (w/w) of the chromophore of the formula

wherein

A=H or CH 3 ;

X=O or NH;

n=2-6;

m=0-6; and

R=H, C 1 -C 4 alkyl, or C 1 -C 4 alkoxy.

5. The ophthalmic device material of claim 4 wherein the ophthalmic device material comprises from 0.1 to 5% (w/w) of the chromophore of the formula

wherein

A=H or CH 3 ;

X=O or NH;

n=2-6;

m=0-6; and

R=H, C 1 -C 4 alkyl, or C 1 -C 4 alkoxy.

6. The ophthalmic device material of claim 3 wherein the ophthalmic device material comprises a device-forming monomer of formula [II]:

where in formula [II]:

A is H, CH 3 , CH 2 CH 3 , or CH 2 OH;

B is (CH 2 ) m or [O(CH 2 ) 2 ] z ;

C is (CH 2 ) w ;

m is 0-6;

z is 1-10;

Y is nothing, O, S, or NR′, provided that if Y is O, S, or NR′, then B is (CH 2 ) m ;

R′ is H, CH 3 , C n′ H 2n′+1 (n′=1-10), iso-OC 3 H 7 , C 6 H 5 , or CH 2 C 6 H 5 ;

w is 0-6, provided that m+w≦8; and

D is H, C 1 -C 4 alkyl, C 1 -C 4 alkoxy, C 6 H 5 , CH 2 C 6 H 5 or halogen.

7. The ophthalmic device material of claim 6 wherein in formula [II]:

A is H or CH 3 ;

B is (CH 2 ) m ;

m is 1-5;

Y is nothing or O;

w is 0-1; and

D is H.

8. The ophthalmic device material of claim 7 wherein the ophthalmic device material comprises a monomer selected from the group consisting of: benzyl methacrylate; 2-phenylethyl methacrylate; 4-phenylbutyl methacrylate; 5-phenylpentyl methacrylate; 2-benzyloxyethyl methacrylate; and 3-benzyloxypropyl methacrylate; and their corresponding acrylates.

9. The ophthalmic device material of claim 3 wherein the ophthalmic device material comprises a cross-linking agent.

10. An ophthalmic device comprising the ophthalmic device material of claim 3 .

11. The ophthalmic device of claim 10 wherein the ophthalmic device is selected from the group consisting of an intraocular lens; a contact lens; a keratoprosthesis; and a corneal inlay or ring.

12. An intraocular lens comprising the chromophore of claim 1 .

Assignments (3)
CONFIRMATORY DEED OF ASSIGNMENT EFFECTIVE APRIL 8, 2019 Recorded Dec 10, 2019
From: NOVARTIS AG
To: ALCON INC.
Reel/Frame 051454/0788 →
MERGER Recorded May 31, 2011
From: ALCON, INC.
To: NOVARTIS AG
Reel/Frame 026376/0076 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Aug 7, 2008
From: WEINSCHENK, JOSEPH I., III; SCHLUETER, DOUGLAS C.; JINKERSON, DAVID L.
To: ALCON, INC.
Reel/Frame 021353/0755 →