Ophthalmic lens materials containing chromophores that absorb both UV and short wavelength visible light
View Patent ↗Chromophores that absorb both UV and short wavelength visible light are disclosed. The chromophores are particularly suitable for use in intraocular lens materials.
1. A chromophore of the formula
wherein
A=H or CH 3 ;
X=O or NH;
n=2-6;
m=0-6; and
R=H, C 1 -C 4 alkyl, or C 1 -C 4 alkoxy.
2. The chromophore of claim 1 wherein
A=CH 3 ;
X=NH;
n=2;
m=0; and
R=CH 3 .
3. An ophthalmic device material comprising the chromophore of claim 1 and a device-forming monomer selected from the group consisting of acrylic monomers and silicone-containing monomers.
4. The ophthalmic device material of claim 3 wherein the ophthalmic device material comprises from 0.1 to 5% (w/w) of the chromophore of the formula
wherein
A=H or CH 3 ;
X=O or NH;
n=2-6;
m=0-6; and
R=H, C 1 -C 4 alkyl, or C 1 -C 4 alkoxy.
5. The ophthalmic device material of claim 4 wherein the ophthalmic device material comprises from 0.1 to 5% (w/w) of the chromophore of the formula
wherein
A=H or CH 3 ;
X=O or NH;
n=2-6;
m=0-6; and
R=H, C 1 -C 4 alkyl, or C 1 -C 4 alkoxy.
6. The ophthalmic device material of claim 3 wherein the ophthalmic device material comprises a device-forming monomer of formula [II]:
where in formula [II]:
A is H, CH 3 , CH 2 CH 3 , or CH 2 OH;
B is (CH 2 ) m or [O(CH 2 ) 2 ] z ;
C is (CH 2 ) w ;
m is 0-6;
z is 1-10;
Y is nothing, O, S, or NR′, provided that if Y is O, S, or NR′, then B is (CH 2 ) m ;
R′ is H, CH 3 , C n′ H 2n′+1 (n′=1-10), iso-OC 3 H 7 , C 6 H 5 , or CH 2 C 6 H 5 ;
w is 0-6, provided that m+w≦8; and
D is H, C 1 -C 4 alkyl, C 1 -C 4 alkoxy, C 6 H 5 , CH 2 C 6 H 5 or halogen.
7. The ophthalmic device material of claim 6 wherein in formula [II]:
A is H or CH 3 ;
B is (CH 2 ) m ;
m is 1-5;
Y is nothing or O;
w is 0-1; and
D is H.
8. The ophthalmic device material of claim 7 wherein the ophthalmic device material comprises a monomer selected from the group consisting of: benzyl methacrylate; 2-phenylethyl methacrylate; 4-phenylbutyl methacrylate; 5-phenylpentyl methacrylate; 2-benzyloxyethyl methacrylate; and 3-benzyloxypropyl methacrylate; and their corresponding acrylates.
9. The ophthalmic device material of claim 3 wherein the ophthalmic device material comprises a cross-linking agent.
10. An ophthalmic device comprising the ophthalmic device material of claim 3 .
11. The ophthalmic device of claim 10 wherein the ophthalmic device is selected from the group consisting of an intraocular lens; a contact lens; a keratoprosthesis; and a corneal inlay or ring.
12. An intraocular lens comprising the chromophore of claim 1 .