Methods for reduction of adhesion formation using cytokine inhibitors
View Patent ↗The present invention relates to a method for prevention or reduction of scar tissue and/or adhesion formation wherein a therapeutically effective amount of a substance that inhibits a pro-inflammatory cytokine is administered to a patient in need of said treatment.
1. A method for reduction of adhesion formation comprising administering a therapeutically effective amount of a substance that inhibits a pro-inflammatory cytokine to a patient in need thereof, wherein:
the administration of the substance that inhibits a pro-inflammatory cytokine causes a reduction of adhesion formation;
said substance is a peptide derived from amino acid 12 to amino acid 40 of human lactoferrin comprising 20 Cys-Phe-Gln-Trp-Gln-Arg-Asn-Met-Arg-Lys-Val-Arg 31 (SEQ ID NO:38); and
said peptide is selected from the group consisting of SEQ ID NOs: 2, 4, 5, 47, 49, 51, 63, 65, and 67.
2. The method of claim 1 , for treatment of post-traumatic tissue injury.
3. The method of claim 2 , wherein said post-traumatic tissue injury is caused by surgery.
4. The method of claim 1 , for treatment of a thermic injury.
5. The method of claim 1 , for treatment of a pathological condition with scar formation.
6. The method of claim 5 , wherein said pathological condition with scar formation is caused by a vascular disease selected from the group consisting of bleeding and infarct.
7. The method of claim 5 , wherein said pathological condition with scar formation is caused by a toxic influence.
8. The method of claim 5 , wherein said pathological condition with scar formation is caused by cystic fibrosis.
9. The method of claim 1 , wherein said substance is locally administered.
10. The method of claim 1 , wherein said substance is systemically administered.