Embolization particles and method for making same
View Patent ↗In at least one embodiment of the present invention, a method for making embolization particles for occluding fluid flow through a body vessel is provided. The method comprises positioning an elongated body of biocompatible material relative to a cutting device. The elongated body is defined by extrusion of a body cross-section along a longitudinal axis. The elongated body is cut with a cutting device at a plurality of locations along the longitudinal axis to form the embolization particles such that each of the embolization particles has a particle cross-section that corresponds to the body cross-section.
1. A method for making embolization particles for occluding fluid flow through a body vessel, the method comprising:
moving an elongated body of biocompatible material relatively towards a guide member and a cutting device, the elongated body defined by extrusion of a body cross-section along a longitudinal axis, the guide member having an opening formed therethrough for guiding the elongated body toward the cutting device;
tensioning the elongated body between at least two tensioning members, the tensioning members being longitudinally spaced apart along the elongated body;
coating the elongated body with a medicant;
feeding the elongated body through the opening of the guide member toward the cutting device, the guide member being disposed downstream of the tensioning members; and
cutting the elongated body with the cutting device at a plurality of locations along the longitudinal axis to form the embolization particles such that each of the embolization particles has a particle cross-section that substantially matches the body cross-section.
2. The method according to claim 1 wherein the body cross-section is substantially circular.
3. The method according to claim 2 wherein the body cross-section has a diameter in the range of about 100 to 400 μm.
4. The method according to claim 1 wherein the plurality of locations along the longitudinal axis are spaced apart in the range of about 300 to 500 μm.
5. The method according to claim 1 wherein the step of cutting includes cutting the elongated body transverse to the longitudinal axis at the plurality of locations.
6. The method according to claim 1 wherein the biocompatible material includes a biodegradable polymer.
7. The method according to claim 1 wherein the cutting device includes one of a shearing element and a laser for cutting the elongated body.
8. The method according to claim 1 wherein the step of coating the elongated body with a medicant is performed during the step of tensioning the elongated body.
9. The method according to claim 1 further comprising coating the elongated body with a medicant by one of spray coating and dip coating the medicant onto the elongated body.
10. The method according to claim 1 wherein the biocompatible material contains an additive comprising at least one of a medicant and a radiopacifier.