NAPHTHYLPYRIMIDINE, NAPHTHYLPYRAZINE AND NAPHTHYLPYRIDAZINE ANALOGS AND THEIR USE AS AGONISTS OF THE WNT-BETA-CATENIN CELLULAR MESSAGING SYSTEM

1 . A compound of Formula (A):

or a pharmaceutically acceptable salt thereof, wherein

T 1 , T 2 , T 3 and T 4 are independently CH or N, wherein two of T 1 , T 2 , T 3 and T 4 are N and the remaining two of T 1 , T 2 , T 3 and T 4 are CH;

Q is a bond, O, N(CH 2 ) r R 8 or CR 8 R 9 ;

U is N or CR 10 ;

W is CHR 5 , O, or NR 5 ;

each R 1 is independently H or C 1 -C 6 alkyl;

R 2 is C 1 -C 10 alkyl optionally substituted with one or two substitutents independently selected form a group consisting of NR 11 R 12 , COR 11 , CO 2 R 11 , CONR 11 R 12 , OR 11 , SO x R 11 and SO 2 NR 11 R 12 ; or R 1 and R 2 when taken together with the ring to which they are attached form a C 8 -C 12 bicyclic cycloakyl or an 8- to 12-membered bicyclic heterocycle;

R 3 is H, halogen, OR 11 or C 1 -C 10 alkyl optionally substituted with one or two substitutents independently selected form a group consisting of NO 2 , NR 11 R 12 , COR 11 , CO 2 R 11 , CONR 11 R 12 , OR 11 , SO x R 11 and SO 2 NR 11 R 12 ; or R 2 and R 3 when taken together with the ring to which they are attached form a C 8 -C 12 bicyclic cycloakyl or an 8- to 12-membered bicyclic heterocycle;

R 4 is H, halogen, OR 11 , NR 11 R 12 , C 1-6 alkyl optionally substituted with at least one and up to two substitutents independently selected form a group consisting of NR 10 R 11 , COR 10 , CO 2 R 10 , CONR 10 R 11 , OR 10 , SO x R 10 and SO 2 NR 10 R 11 ; or R 3 and R 4 when taken together with the carbon to which they are attached to form a C 3 -C 8 monocyclic cycloalkyl, or a 3- to 7-membered monocyclic heterocycle;

R 5 is independently H, 5-12-membered heteroaryl, OH, CN, OR 10 , NR 11 R 12 , COR 11 , CO 2 R 11 , CONR 11 R 12 , CSNR 11 R 12 , SO x R 11 , SO 2 NR 11 R 12, NHSO 2 R 11, NHSO 2, NR 11 R 12 , NHCONR 11 R 12 , NHC(═NR 11 )NR 11 R 12 , N 3 or C 1- C 6 alkyl optionally substituted with halogen, R 11, OR 10 , or NR 11 R 12 ; or R 5 and R 4 when taken together with the carbon to which they are attached to form a C 3 -C 8 monocyclic cycloalkyl or a 3- to 7-membered monocyclic heterocycle;

or R 5 and R 2 when taken together with the ring to which they are attached to form an C 8 -C 12 bicyclic cycloalkyl or an 8- to 12-membered bicyclic heterocycle; or R 5 and R 1 when taken together with the ring to which they are attached form an C 8 -C 12 bicyclic cycloalkyl or an 8- to 12-membered bicyclic heterocycle;

R 6 and R 7 are independently H, halogen, CN, NO 2 , R 11 , OR 11 , SO x R 11 , NR 11 R 12 ;

R 8 , R 9 and R 10 are independently H, C 1 -C 6 alkyl optionally substituted with aryl or with CO 2 R 13 , or R 8 and R 9 taken together are ═O;

R 11 is H; C 2 -C 6 alkenyl; C 1 -C 6 alkyl optionally substituted with OR 13 , N R 13 R 14 , halogen or with 3-7-membered monocyclic heterocycle; cycloalkyl or monocyclic or bicyclic heterocycle; aryl optionally substituted with halogen, NR 13 R 14 , CN or C 1 -C 6 alkyl; arylalkyl, COR 13 , CO 2 R 13 , CONR 13 R 14 , SO 2 R 13 , SO 2 NR 13 R 14 or C(═NR 13 )NR 13 R 14 ;

R 12 is H; C 1 -C 6 alkyl; aryl optionally substituted with C 1 -C 6 alkyl; arylalkyl, COR 13 , CO 2 R 13 , CONR 13 R 14 , SO 2 R 13 , SO 2 NR 13 R 14 or C(═NR 13 )NR 13 R 14 ; or R 11 and R 12 when taken together with N to which they are attached form a 3- to 7-membered monocyclic heterocycle; or 8-12-membered bicyclic heterocycle, wherein the monocyclic heterocycle, or the bicyclic heterocycle is optionally substituted with one or two alkyl, ═O, NR 13 R 14 , OR 13 or CH 2 OR 13 ;

R 13 is H, C 1 -C 6 alkyl optionally substituted with halogen, CO—C 1 -C 6 alkyl optionally substituted with halogen, CO-aryl, SO 2 C 1 -C 6 alkyl, SO 2 -aryl, SO 2 -di(C 1 -C 6 )alkylamino, di(C 1 -C 6 )alkylamino, COO—C 1 -C 6 alkyl, COO-aryl optionally substituted with alkyl, NHCOO-arylalkyl, aryl optionally substituted with alkyl;

R 14 is H or C 1 -C 6 alkyl; or R 13 and R 14 when taken together with the N to which they are attached to form a 3- to 7-membered monocyclic heterocycle;

m, n, o, p, and x are independently 0,1 or 2;

s is 0 or 1; and

r is 0, 1, 2 or 3.

2 . The compound of claim 1 , wherein R 7 is H or OR 11 .

3 . The compound of claim 1 , wherein R 5 is 5-10-membered heteroaryl.

4 . The compound of claim 3 , wherein R 5 is 5-7-membered heteroaryl

5 . The compound of claim 1 , wherein Q is a bond or N(CH 2 ) r R 8 .

6 . The compound of claim 5 , wherein Q is a bond.

7 . The compound of claim 1 , wherein r is 0, 1 or 2.

8 . The compound of claim 1 , wherein R 8 is H.

9 . The compound of claim 1 , wherein Formula (A) is Formula (AI):

wherein Q, U, R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , m, n, o, p and s are as defined in claim 1 .

10 . The compound of claim 1 , wherein the 3- to 7-membered heterocycle formed by R 3 and R 4 is a 5, 6, or 7-membered heteroaryl.

11 . The compound of claim 1 , wherein the 3- to 7-membered heterocycle formed by R 5 and R 4 is a 5, 6, or 7-membered heteroaryl.

12 . The compound of claim 1 , wherein the 3- to 7-membered heterocycle formed by R 11 and R 12 is a 5, 6, or 7-membered heteroaryl.

13 . The compound of claim 1 , wherein 3- to 7-membered heterocycle formed by R 13 and R 14 is a 5, 6, or 7-membered heteroaryl.

14 . The compound of claim 1 , wherein the R 11 is Cl-C 6 alkyl optionally substituted with a 5-7 membered heteroaryl.

15 . The compound of claim 1 , wherein

is selected from the group consisting of

wherein R 1 , R 2 , R 3 , R 4 , R 5 , m, n and s are as defined in claim 1 .

16 . The compound of claim 1 , wherein

wherein R 1 , R 2 , R 3 , R 4 , R 5 , s, m, and n are as defined in claim 1 .

17 . The compound of claim 16 , wherein n=1 and m=1.

18 . The compound of claim 16 , wherein n=1 and m=0.

19 . The compound of claim 16 , where n=2 and m=0.

20 . The compound of claim 16 , wherein R 2 is CH 2 OR 11 .

21 . The compound of claim 16 , wherein R 3 is OR 11 or CH 2 OR 11 .

22 . The compound of claim 16 , wherein R 4 is OR 11 .

23 . The compound of claim 16 , wherein R 5 is CN; N R 11 R 12 ; C(S)N R 11 R 12 ; or alkyl optionally substituted with N R 11 R 12 , monocyclic heterocycle, or bicyclic heterocycle.

24 . The compound of claim 16 , wherein

wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 11 , R 12 , s, m and n are as defined in claim 16 .

25 . The compound of claim 16 , wherein

wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 12 , R 13 , R 14 , s, m, and n are as defined in claim 16 .

26 . The compound of claim 25 , wherein

wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 12 , R 13 , R 14 , s, m, and n are as defined in claim 25 .

27 . The compound of claim 15 , wherein

wherein m is 0 or 1.

28 . The compound of claim 1 , wherein Formula (A) is

wherein Q, U, R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , m, n, o, p and s are as defined in claim 1 .

29 . The compound of claim 1 , wherein Formula (A) is Formula (I):

wherein

Q is a bond or CR 8 R 9 ;

U is N or CR 10 ;

R 1 is H or C 1- C 6 alkyl;

R 2 is C 1 -C 10 alkyl substituted with 0, 1 or 2 of NR 11 R 12 , COR 11 , CO 2 R 11 , CONR 11 R 12 , OR 11 , S(O) x R 11 , or SO 2 NR 11 R 12 ; or R 1 and R 2 when taken together with the ring to which they are attached form an 8- to 12-membered bicyclic heterocycle;

R 3 is H, halogen, C 1- C 10 alkyl substituted with 0, 1 or 2 of NR 11 R 12 , COR 11 , CO 2 R 11 , CONR 11 R 12 , OR 11 , S(O) x R 11 , or SO 2 NR 11 R 12 ; or R 2 and R 3 when taken together with the ring to which they are attached form an 8- to 12-membered bicyclic heterocycle or homocycle;

R 4 is H, halogen, OR 11 , NR 11 R 12 , C 1- C 6 alkyl substituted with at least one and up to two of NR 10 R 11 , COR 10 , CO 2 R 10 , CONR 10 R 11 , OR 10 , S(O) x R 10 , or SO 2 NR 10 R 11 ; or R 3 and R 4 when taken together with the carbon to which they are attached form a C 3 -C 8 monocyclic cycloalkyl or a 3- to 7-membered monocyclic heterocycle;

R 5 is H, OR 10 , NR 10 R 11 or C 1- C 6 alkyl optionally substituted with OR 10 , or NR 10 R 11 ; or R 5 and R 4 when taken together form a C 3 -C 8 monocyclic cycloalkyl or a 3- to 7-membered monocyclic heterocycle; or R 5 and R 2 , as well as R 5 and R 1 , when taken together along with the ring to which they are attached form an C 8 -C 12 bicyclic cycloalkyl or an 8- to 12-membered bicyclic heterocycle;

R 6 and R 7 are independently H, halogen, CN, NO 2 , R 11 , OR 11 , S(O) x R 11 , or NR 11 R 12 ;

R 8 and R 9 are ═O or independently H or C 1- C 6 alkyl

R 10 is H or C 1- C 6 alkyl;

R 11 is H, C 1- C 6 alkyl, aryl, or alkylaryl;

R 12 is H, C 1- C 6 alkyl, aryl, alkylaryl, COR 13 , CO 2 R 13 , CONR 13 R 14 , SO 2 R 13 ; or R 11 and R 12 when taken together with the N to which they are attached form a C 3 -C 8 monocyclic cycloalkyl, a 3- to 7-membered monocyclic heterocycle, an C 8 -C 12 bicyclic cycloalkyl, or an 8- to 12-membered bicyclic heterocycle, all optionally substituted with R 11 and OR 11 ;

R 13 is H or C 1- C 6 alkyl;

R 14 is H or C 1- C 6 alkyl; or R 13 and R 14 when taken together with the N to which they are attached form a C 3 -C 8 monocyclic cycloalkyl or a 3- to 7-membered monocyclic heterocycle;

m, n, o and p are independently 0, 1 or 2; and

x is 0, 1, or 2.

30 . A compound of the Formula (II):

or pharmaceutically acceptable salts thereof,

wherein

R 1 and R 2 are independently —H; C 1 -C 6 alkyl optionally substituted with C1-C6 alkoxy, hydroxyl, or C6-C10 aryl; C(O)C 1 -C 6 alkyl, C(O)NC 1 -C 6 alkyl, a C 3 -C 8 monocyclic cycloalkyl, or a 3- to 7-membered monocyclic heterocycle, with the proviso that R 1 and R 2 are not both H;

R 6 and R 7 are independently H, halogen, CN, NO 2 , R 11 , OR 11 , S(O) x R 11 , or NR 11 R 12 ;

R 11 is H, C 1 -C 6 alkyl, aryl or alkylaryl;

R 12 is H, C 1 -C 6 alkyl, aryl, alkylaryl, COR 13 , CO 2 R 13 , CONR 13 R 14 , or SO 2 R 13 ; or R 11 and R 12 when taken together with the N to which they are attached form a 3- to 7-membered monocyclic heterocycle or an 8- to 12-membered bicyclic heterocycle;

R 13 is H or C 1- C 6 alkyl;

R 14 is H or C 1- C 6 alkyl; or R 13 and R 14 when taken together with the N to which they are attached form a 3- to 7-membered monocyclic heterocycle;

o and p are independently 0, 1 or 2; and

x is 0, 1, or 2.

31 . The compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein the compound is

tert-butyl {(3S)-1-[4-(2-naphthyl)pyrimidin-2-yl]pyrrolidin-3-yl}carbamate;

(3S)-1-[4-(2-naphthyl)pyrimidin-2-yl]pyrrolidin-3-amine;

4-[4-(2-naphthyl)pyrimidin-2-yl]-1,4-diazepane-1-carbaldehyde;

1-[4-(2-naphthyl)pyrimidin-2-yl]-1,4-diazepane;

1-[4-(2-naphthyl)pyrimidin-2-yl]azepan-4-amine;

tert-butyl {1-[4-(2-naphthyl)pyrimidin-2-yl]azepan-4-yl}carbamate;

tert-butyl ({1-[4-(2-naphthyl)pyrimidin-2-yl]azetidin-3-yl}methyl)carbamate;

1-{1-[4-(2-naphthyl)pyrimidin-2-yl]azetidin-3-yl }methanamine;

tert-butyl ({1-[4-(2-naphthyl)pyrimidin-2-yl]pyrrolidin-3-yl}methyl)carbamate;

1-{1-[4-(2-naphthyl)pyrimidin-2-yl]pyrrolidin-3-yl}methanamine;

4-(2-{4-[4-(2-naphthyl)pyrimidin-2-yl]piperazin-1-yl}ethyl)morpholine;

4-({4-[4-(2-naphthyl)pyrimidin-2-yl]piperazin-1-yl}acetyl)morpholine;

N,N-dimethyl-2-{4-[4-(2-naphthyl)pyrimidin-2-yl]piperazin-1-yl}ethanamine;

2-(4-methylpiperazin-1-yl)-4-(2-naphthyl)pyrimidine;

4-(2-naphthyl)-2-(4-pyridin-2-ylpiperazin-1-yl)pyrimidine;

4-(2-naphthyl)-2-(4-pyrimidin-2-ylpiperazin-1-yl)pyrimidine;

1-{1-[4-(2-naphthyl)pyrimidin-2-yl]piperidin-4-yl}-1,3-dihydro-2H-benzimidazol-2-one;

2-[4-(2-naphthyl)pyrimidin-2-yl]-1,2,3,4-tetrahydroisoquinoline;

(2-{4-[4-(2-naphthyl)pyrimidin-2-yl]piperazin-1-yl}ethyl)amine;

N,N-dimethyl-3-{4-[4-(2-naphthyl)pyrimidin-2-yl]piperazin-1-yl}propan-1-amine;

4-(2-naphthyl)-2-(4-pyridin-4-ylpiperazin-1-yl)pyrimidine;

4-(3-{4-[4-(2-naphthyl)pyrimidin-2-yl]piperazin-1-yl}propyl)morpholine;

2-[4-(2-furoyl)piperazin-1-yl]-4-(2-naphthyl)pyrimidine;

tert-butyl {(3R)-1-[4-(2-naphthyl)pyrimidin-2-yl]pyrrolidin-3-yl}carbamate;

(3R)-1-[4-(2-naphthyl)pyrimidin-2-yl]pyrrolidin-3-amine;

N,N-dimethyl-1-[4-(2-naphthyl)pyrimidin-2-yl]pyrrolidin-3-amine;

N,N-diethyl-1-[4-(2-naphthyl)pyrimidin-2-yl]pyrrolidin-3-amine;

(3R)-N-methyl-1-[4-(2-naphthyl)pyrimidin-2-yl]pyrrolidin-3-amine;

(3S)-N-methyl-1-[4-(2-naphthyl)pyrimidin-2-yl]pyrrolidin-3-amine;

(3S)-N,N-dimethyl-1-[4-(2-naphthyl)pyrimidin-2-yl]pyrrolidin-3-amine;

(3R)-N,N-dimethyl-1-[4-(2-naphthyl)pyrimidin-2-yl]pyrrolidin-3-amine;

N-methyl-N-{(3S)-1-[4-(2-naphthyl)pyrimidin-2-yl]pyrrolidin-3-yl}acetamide;

{1-[4-(2-naphthyl)pyrimidin-2-yl]piperidin-4-yl}methanol;

2-{1-[4-(2-naphthyl)pyrimidin-2-yl]piperidin-4-yl}ethanol;

ethyl 1-[4-(2-naphthyl)pyrimidin-2-yl]piperidine-4-carboxylate;

ethyl {1-[4-(2-naphthyl)pyrimidin-2-yl]piperidin-4-yl}acetate;

{(2S)-1-[4-(2-naphthyl)pyrimidin-2-yl]pyrrolidin-2-yl}methanol;

1-[4-(2-naphthyl)pyrimidin-2-yl]pyrrolidin-3-ol;

4-[4-(2-naphthyl)pyrimidin-2-yl]morpholine;

{1-[4-(2-naphthyl)pyrimidin-2-yl]piperidin-2-yl}methanol;

{1-[4-(2-naphthyl)pyrimidin-2-yl]piperidin-3-yl}methanol;

1-[4-(2-naphthyl)pyrimidin-2-yl]piperidin-4-ol;

1-[4-(2-naphthyl)pyrimidin-2-yl]piperidin-3-ol;

{(2R)-1-[4-(2-naphthyl)pyrimidin-2-yl]pyrrolidin-2-yl}methanol;

4-(2-naphthyl)-2-pyrrolidin-1-ylpyrimidine;

4-(2-naphthyl)-2-piperidin-1-ylpyrimidine;

2-(4-methylpiperidin-1-yl)-4-(2-naphthyl)pyrimidine;

1-[4-(2-naphthyl)pyrimidin-2-yl]azepane;

tert-butyl {1-[4-(2-naphthyl)pyrimidin-2-yl]piperidin-4-yl}carbamate;

tert-butyl 4-[4-(2-naphthyl)pyrimidin-2-yl]piperazine-1-carboxylate;

1-[4-(2-naphthyl)pyrimidin-2-yl]piperidin-4-amine;

4-(2-naphthyl)-2-piperazin-1-ylpyrimidine;

tert-butyl ({1-[4-(2-naphthyl)pyrimidin-2-yl]piperidin-3-yl}methyl)carbamate;

({1-[4-(2-naphthyl)pyrimidin-2-yl]piperidin-3-yl}methyl)amine;

(1R,5S,6s)-3-[4-(2-naphthyl)pyrimidin-2-yl]-3-azabicyclo[3.1.0]hexan-6-amine;

({1-[4-(2-naphthyl)pyrimidin-2-yl]piperidin-4-yl}methyl)amine;

1-[4-(2-naphthyl)pyrimidin-2-yl]piperidine-4-carboxamide;

8-[4-(2-naphthyl)pyrimidin-2-yl]-1,4-dioxa-8-azaspiro[4.5]decane;

methyl 1-[4-(2-naphthyl)pyrimidin-2-yl]piperidine-4-carboxylate;

1-[4-(2-naphthyl)pyrimidin-2-yl]piperidine-3-carboxamide;

{(3S)-1-[4-(2-naphthyl)pyrimidin-2-yl]piperidin-3-yl}methanol;

{(3R)-1-[4-(2-naphthyl)pyrimidin-2-yl]piperidin-3-yl}methanol;

N-{(3S)-1-[4-(2-naphthyl)pyrimidin-2-yl]pyrrolidin-3-yl}acetamide;

N-({1-[4-(2-naphthyl)pyrimidin-2-yl]piperidin-4-yl}methyl)guanidine;

N-ethyl-4-[4-(2-naphthyl)pyrimidin-2-yl]-1,4-diazepane-1-carboxamide;

methyl 4-[4-(2-naphthyl)pyrimidin-2-yl]-1,4-diazepane-1-carboxylate;

ethyl 4-[4-(2-naphthyl)pyrimidin-2-yl]-1,4-diazepane-1-carboxylate;

1-acetyl-4-[4-(2-naphthyl)pyrimidin-2-yl]-1,4-diazepane;

1-[4-(2-naphthyl)pyrimidin-2-yl]-4-propionyl-1,4-diazepane;

1-[4-(2-naphthyl)pyrimidin-2-yl]-4-(trifluoroacetyl)-1,4-diazepane;

N,N-diethyl-4-[4-(2-naphthyl)pyrimidin-2-yl]-1,4-diazepane-1-carboxamide;

1-(methylsulfonyl)-4-[4-(2-naphthyl)pyrimidin-2-yl]-1,4-diazepane;

N,N-dimethyl-4-[4-(2-naphthyl)pyrimidin-2-yl]-1,4-diazepane-1-sulfonamide;

N,N-dimethyl-4-[4-(2-naphthyl)pyrimidin-2-yl]-1,4-diazepane-1-carboxamide;

4-[4-(2-naphthyl)pyrimidin-2-yl]-1,4-diazepane-1-carboxamide;

1-benzoyl-4-[4-(2-naphthyl)pyrimidin-2-yl]-1,4-diazepane;

1-[(4-methylphenyl)sulfonyl]-4-[4-(2-naphthyl)pyrimidin-2-yl]-1,4-diazepane;

N-{1-[4-(2-naphthyl)pyrimidin-2-yl]azepan-4-yl}acetamide;

2,2,2-trifluoro-N-{1-[4-(2-naphthyl)pyrimidin-2-yl]azepan-4-yl}acetamide;

N,N-dimethyl-N′-{1-[4-(2-naphthyl)pyrimidin-2-yl]azepan-4-yl}urea;

N-{1-[4-(2-naphthyl)pyrimidin-2-yl]azepan-4-yl}benzamide;

N-{1-[4-(2-naphthyl)pyrimidin-2-yl]azepan-4-yl}urea;

N-ethyl-N′-{1-[4-(2-naphthyl)pyrimidin-2-yl]azepan-4-yl}urea;

N-{1-[4-(2-naphthyl)pyrimidin-2-yl]azepan-4-yl}methanesulfonamide;

4-methyl-N-{1-[4-(2-naphthyl)pyrimidin-2-yl]azepan-4-yl}benzenesulfonamide;

N,N-dimethyl-N′-{1-[4-(2-naphthyl)pyrimidin-2-yl]azepan-4-yl}sulfamide;

N-({1-[4-(2-naphthyl)pyrimidin-2-yl]azetidin-3-yl}methyl)acetamide;

2,2,2-trifluoro-N-({1-[4-(2-naphthyl)pyrimidin-2-yl]azetidin-3-yl}methyl)acetamide;

N,N-dimethyl-N′-({1-[4-(2-naphthyl)pyrimidin-2-yl]azetidin-3-yl}methyl)urea;

methyl ({1-[4-(2-naphthyl)pyrimidin-2-yl]azetidin-3-yl}methyl)carbamate;

N-({1-[4-(2-naphthyl)pyrimidin-2-yl]azetidin-3-yl}methyl)urea;

N-ethyl-N′-({1-[4-(2-naphthyl)pyrimidin-2-yl]azetidin-3-yl}methyl)urea;

N-({1-[4-(2-naphthyl)pyrimidin-2-yl]azetidin-3-yl}methyl)methanesulfonamide;

4-methyl-N-({1-[4-(2-naphthyl)pyrimidin-2-yl]azetidin-3-yl}methyl)benzenesulfonamide;

{1-[4-(2-naphthyl)pyrimidin-2-yl]azepan-4-yl}formamide;

N,N-dimethyl-N′-(2-{4-[4-(2-naphthyl)pyrimidin-2-yl]piperazin-1-yl}ethyl)urea;

N-(2-{4-[4-(2-naphthyl)pyrimidin-2-yl]piperazin-1-yl}ethyl)methanesulfonamide;

N-(2-{4-[4-(2-naphthyl)pyrimidin-2-yl]piperazin-1-yl}ethyl)dicarbonimidic diamide;

N-ethyl-N′-(2-{4-[4-(2-naphthyl)pyrimidin-2-yl]piperazin-1-yl}ethyl)urea;

N-isopropyl-N′-(2-{4-[4-(2-naphthyl)pyrimidin-2-yl]piperazin-1-yl}ethyl)urea;

diethyl (2-{4-[4-(2-naphthyl)pyrimidin-2-yl]piperazin-1-yl}ethyl)imidodicarbonate;

N-{(3R)-1-[4-(2-naphthyl)pyrimidin-2-yl]pyrrolidin-3-yl}acetamide;

2,2,2-trifluoro-N-{(3R)-1-[4-(2-naphthyl)pyrimidin-2-yl]pyrrolidin-3-yl}acetamide;

methyl {(3R)-1-[4-(2-naphthyl)pyrimidin-2-yl]pyrrolidin-3-yl}carbamate;

N,N-dimethyl-N′-{(3R)-1-[4-(2-naphthyl)pyrimidin-2-yl]pyrrolidin-3-yl}urea;

N-{(3R)-1-[4-(2-naphthyl)pyrimidin-2-yl]pyrrolidin-3-yl}pyrrolidine-1-carboxamide

N-{(3R)-1-[4-(2-naphthyl)pyrimidin-2-yl]pyrrolidin-3-yl}urea;

N,N-dimethyl-N′-{(3R)-1-[4-(2-naphthyl)pyrimidin-2-yl]pyrrolidin-3-yl}sulfamide;

N-{(3R)-1-[4-(2-naphthyl)pyrimidin-2-yl]pyrrolidin-3-yl}methanesulfonamide;

4-methyl-N-{(3R)-1-[4-(2-naphthyl)pyrimidin-2-yl]pyrrolidin-3-yl}benzenesulfonamide;

N-{(3R)-1-[4-(2-naphthyl)pyrimidin-2-yl]pyrrolidin-3-yl}morpholine-4-carboxamide;

ethyl {(3R)-1-[4-(2-naphthyl)pyrimidin-2-yl]pyrrolidin-3-yl}carbamate;

N-isopropyl-N′-{(3R)-1-[4-(2-naphthyl)pyrimidin-2-yl]pyrrolidin-3-yl}urea;

N,N-diethyl-N′-{(3R)-1-[4-(2-naphthyl)pyrimidin-2-yl]pyrrolidin-3-yl}urea;

N-{(3R)-1-[4-(2-naphthyl)pyrimidin-2-yl]pyrrolidin-3-yl}guanidine;

4-chloro-N-{(3R)-1-[4-(2-naphthyl)pyrimidin-2-yl]pyrrolidin-3-yl}benzamide;

4-cyano-N-{(3R)-1-[4-(2-naphthyl)pyrimidin-2-yl]pyrrolidin-3-yl}benzamide;

N-{(3S)-1-[4-(2-naphthyl)pyrimidin-2-yl]pyrrolidin-3-yl}acetamide;

2,2,2-trifluoro-N-{(3S)-1-[4-(2-naphthyl)pyrimidin-2-yl]pyrrolidin-3-yl}acetamide;

N-{(3S)-1-[4-(2-naphthyl)pyrimidin-2-yl]pyrrolidin-3-yl}benzamide;

methyl {(3S)-1-[4-(2-naphthyl)pyrimidin-2-yl]pyrrolidin-3-yl}carbamate;

N,N-dimethyl-N′-{(3S)-1-[4-(2-naphthyl)pyrimidin-2-yl]pyrrolidin-3-yl}urea;

N-{(3S)-1-[4-(2-naphthyl)pyrimidin-2-yl]pyrrolidin-3-yl}pyrrolidine-1-carboxamide

N-ethyl-N′-{(3S)-1-[4-(2-naphthyl)pyrimidin-2-yl]pyrrolidin-3-yl}urea;

N-{(3S)-1-[4-(2-naphthyl)pyrimidin-2-yl]pyrrolidin-3-yl}urea;

N,N-dimethyl-N′-{(3S)-1-[4-(2-naphthyl)pyrimidin-2-yl]pyrrolidin-3-yl}sulfamide;

N-{(3S)-1-[4-(2-naphthyl)pyrimidin-2-yl]pyrrolidin-3-yl}methanesulfonamide;

4-methyl-N-{(3S)-1-[4-(2-naphthyl)pyrimidin-2-yl]pyrrolidin-3-yl}benzenesulfonamide;

N-{(3S)-1-[4-(2-naphthyl)pyrimidin-2-yl]pyrrolidin-3-yl}morpholine-4-carboxamide;

ethyl {(3S)-1-[4-(2-naphthyl)pyrimidin-2-yl]pyrrolidin-3-yl}carbamate;

N-isopropyl-N′-{(3S)-1-[4-(2-naphthyl)pyrimidin-2-yl]pyrrolidin-3-yl}urea;

N,N-diethyl-N′-{(3S)-1-[4-(2-naphthyl)pyrimidin-2-yl]pyrrolidin-3-yl}urea;

4-chloro-N-{(3S)-1-[4-(2-naphthyl)pyrimidin-2-yl]pyrrolidin-3-yl}benzamide;

4-cyano-N-{(3S)-1-[4-(2-naphthyl)pyrimidin-2-yl]pyrrolidin-3-yl}benzamide;

N-({1-[4-(2-naphthyl)pyrimidin-2-yl]pyrrolidin-3-yl}methyl)acetamide;

N-({1-[4-(2-naphthyl)pyrimidin-2-yl]pyrrolidin-3-yl}methyl)benzamide;

methyl ({1-[4-(2-naphthyl)pyrimidin-2-yl]pyrrolidin-3-yl}methyl)carbamate;

N,N-dimethyl-N′-({1-[4-(2-naphthyl)pyrimidin-2-yl]pyrrolidin-3-yl}methyl)urea;

N-ethyl-N′-({1-[4-(2-naphthyl)pyrimidin-2-yl]pyrrolidin-3-yl}methyl)urea;

N-({1-[4-(2-naphthyl)pyrimidin-2-yl]pyrrolidin-3-yl}methyl)urea;

N,N-dimethyl-N′-({1-[4-(2-naphthyl)pyrimidin-2-yl]pyrrolidin-3-yl}methyl)sulfamide;

N-({1-[4-(2-naphthyl)pyrimidin-2-yl]pyrrolidin-3-yl}methyl)methanesulfonamide;

N-({1-[4-(2-naphthyl)pyrimidin-2-yl]pyrrolidin-3-yl}methyl)formamide;

N-(2-{1-[4-(2-naphthyl)pyrimidin-2-yl]piperidin-4-yl}ethyl)acetamide;

2,2,2-trifluoro-N-(2-{1-[4-(2-naphthyl)pyrimidin-2-yl]piperidin-4-yl}ethyl)acetamide;

methyl (2-{1-[4-(2-naphthyl)pyrimidin-2-yl]piperidin-4-yl}ethyl)carbamate;

N,N-dimethyl-N′-(2-{1-[4-(2-naphthyl)pyrimidin-2-yl]piperidin-4-yl}ethyl)urea;

N,N-diethyl-N′-(2-{1-[4-(2-naphthyl)pyrimidin-2-yl]piperidin-4-yl}ethyl)urea;

N-ethyl-N′-(2-{1-[4-(2-naphthyl)pyrimidin-2-yl]piperidin-4-yl}ethyl)urea;

N-isopropyl-N′-(2-{1-[4-(2-naphthyl)pyrimidin-2-yl]piperidin-4-yl}ethyl)urea;

N-(2-{1-[4-(2-naphthyl)pyrimidin-2-yl]piperidin-4-yl}ethyl)urea;

N-cyclohexyl-N′-(2-{1-[4-(2-naphthyl)pyrimidin-2-yl]piperidin-4-yl}ethyl)urea;

N-(2-{1-[4-(2-naphthyl)pyrimidin-2-yl]piperidin-4-yl}ethyl)pyrrolidine-1-carboxamide;

N-(2-{1-[4-(2-naphthyl)pyrimidin-2-yl]piperidin-4-yl}ethyl)morpholine-4-carboxamide;

N,N-dimethyl-N′-(2-{1-[4-(2-naphthyl)pyrimidin-2-yl]piperidin-4-yl}ethyl)sulfamide;

N-(2-{1-[4-(2-naphthyl)pyrimidin-2-yl]piperidin-4-yl}ethyl)methanesulfonamide;

benzyl (2-{1-[4-(2-naphthyl)pyrimidin-2-yl]piperidin-4-yl}ethyl)carbamate;

N-(2-{1-[4-(2-naphthyl)pyrimidin-2-yl]piperidin-4-yl}ethyl)-N′-phenylurea;

N-(2-{1-[4-(2-naphthyl)pyrimidin-2-yl]piperidin-4-yl}ethyl)benzamide;

N-({1-[4-(2-naphthyl)pyrimidin-2-yl]piperidin-4-yl}methyl)acetamide;

N-({1-[4-(2-naphthyl)pyrimidin-2-yl]piperidin-4-yl}methyl)acetamide;

N-({1-[4-(2-naphthyl)pyrimidin-2-yl]piperidin-4-yl}methyl)benzamide;

methyl ({1-[4-(2-naphthyl)pyrimidin-2-yl]piperidin-4-yl}methyl)carbamate;

N,N-dimethyl-N′-({1-[4-(2-naphthyl)pyrimidin-2-yl]piperidin-4-yl}methyl)urea;

N-({1-[4-(2-naphthyl)pyrimidin-2-yl]piperidin-4-yl}methyl)pyrrolidine-1-carboxamide

N-ethyl-N′-({1-[4-(2-naphthyl)pyrimidin-2-yl]piperidin-4-yl}methyl)urea;

N-({1-[4-(2-naphthyl)pyrimidin-2-yl]piperidin-4-yl}methyl)urea;

N,N-dimethyl-N′-({1-[4-(2-naphthyl)pyrimidin-2-yl]piperidin-4-yl}methyl)sulfamide;

N-({1-[4-(2-naphthyl)pyrimidin-2-yl]piperidin-4-yl}methyl)methanesulfonamide;

4-methyl-N-({1-[4-(2-naphthyl)pyrimidin-2-yl]piperidin-4-yl}methyl)benzenesulfonamide;

N-({1-[4-(2-naphthyl)pyrimidin-2-yl]piperidin-4-yl}methyl)pyrimidin-2-amine;

di-tert-butyl {(Z)-[({1-[4-(2-naphthyl)pyrimidin-2-yl]piperidin-4-yl}methyl) amino]methylylidene}biscarbamate;

di-tert-butyl ((E)-{4-[4-(2-naphthyl)pyrimidin-2-yl]piperazin-1-yl}methylylidene)biscarbamate;

4-[4-(2-naphthyl)pyrimidin-2-yl]piperazine-1-carboximidamide;

{1-[4-(2-naphthyl)pyrimidin-2-yl]piperidin-4-yl}methyl 4-methylbenzenesulfonate;

2-{1-[4-(2-naphthyl)pyrimidin-2-yl]piperidin-4-yl}ethyl methanesulfonate;

2-[4-(2-azidoethyl)piperidin-1-yl]-4-(2-naphthyl)pyrimidine;

N,N-dimethyl-1-{1-[4-(2-naphthyl)pyrimidin-2-yl]piperidin-4-yl}methanamine;

N-methyl-1-{1-[4-(2-naphthyl)pyrimidin-2-yl]piperidin-4-yl}methanamine;

2-[4-(1H-imidazol-1-ylmethyl)piperidin-1-yl]-4-(2-naphthyl)pyrimidine;

4-(2-naphthyl)-2-[4-(pyrrolidin-1-ylmethyl)piperidin-1-yl]pyrimidine;

N-ethyl-N-({1-[4-(2-naphthyl)pyrimidin-2-yl]piperidin-4-yl}methyl)ethanamine;

4-(2-naphthyl)-2-[4-(piperidin-1-ylmethyl)piperidin-1-yl]pyrimidine;

4-(2-naphthyl)-2-[4-(piperidin-1-ylmethyl)piperidin-1-yl]pyrimidine;

N-({1-[4-(2-naphthyl)pyrimidin-2-yl]piperidin-4-yl}methyl)ethanamine;

2-methyl-N-({1-[4-(2-naphthyl)pyrimidin-2-yl]piperidin-4-yl}methyl)propan-1-amine;

2-{1-[4-(2-naphthyl)pyrimidin-2-yl]piperidin-4-yl}ethanamine;

1-[4-(2-naphthyl)pyrimidin-2-yl]piperidin-4-one;

1-[4-(2-naphthyl)pyrimidin-2-yl]piperidine-4-carbaldehyde;

1-[4-(2-naphthyl)pyrimidin-2-yl]piperidine-4-carboxylic acid;

4-methyl-1-[4-(2-naphthyl)pyrimidin-2-yl]piperidin-4-ol;

1-[4-(2-naphthyl)pyrimidin-2-yl]-4-(nitromethyl)piperidin-4-ol;

4-(aminomethyl)-1-[4-(2-naphthyl)pyrimidin-2-yl]piperidin-4-ol;

1-[4-(2-naphthyl)pyrimidin-2-yl]-4-(1-nitroethyl)piperidin-4-ol;

4-(2-naphthyl)-2-[4-(1-nitroethyl)piperidin-1-yl]pyrimidine;

4-(2-naphthyl)-2-[4-(nitromethyl)piperidin-1-yl]pyrimidine;

tert-butyl ((1S)-1-{1-[4-(2-naphthyl)pyrimidin-2-yl]piperidin-4-yl}ethyl)carbamate;

tert-butyl (1-{1-[4-(2-naphthyl)pyrimidin-2-yl]piperidin-4-yl}ethyl)carbamate;

1-{1-[4-(2-naphthyl)pyrimidin-2-yl]piperidin-4-yl}ethanamine;

(1R)-1-{1-[4-(2-naphthyl)pyrimidin-2-yl]piperidin-4-yl}ethanamine;

(1S)-1-{1-[4-(2-naphthyl)pyrimidin-2-yl]piperidin-4-yl}ethanamine;

4-{[4-(2-naphthyl)pyrimidin-2-yl]methyl}-1,4-diazepane-1-carbaldehyde;

1-(1-{[4-(2-naphthyl)pyrimidin-2-yl]methyl}piperidin-4-yl)methanamine;

1-[4-(2-naphthyl)pyrimidin-2-yl]piperidine-4-carbonitrile;

1-[4-(2-naphthyl)pyrimidin-2-yl]piperidine-4-carbothioamide;

2-azetidin-1-yl-4-(2-naphthyl)pyrimidine;

2-azetidin-1-yl-4-(2-naphthyl)pyrimidine;

2-[4-(azidomethyl)piperidin-1-yl]-4-(2-naphthyl)pyrimidine;

1-[4-(2-naphthyl)pyrimidin-2-yl]piperidine-4-carboximidamide;

methyl [(tert-butoxycarbonyl)amino]{1-[4-(2-naphthyl)pyrimidin-2-yl]piperidin-4-ylidene}acetate;

methyl [(tert-butoxycarbonyl)amino]{1-[4-(2-naphthyl)pyrimidin-2-yl]piperidin-4-yl}acetate;

methyl (2R)-[(tert-butoxycarbonyl)amino]{1-[4-(2-naphthyl)pyrimidin-2-yl]piperidin-4-yl}acetate;

methyl (2S)-[(tert-butoxycarbonyl)amino]{1-[4-(2-naphthyl)pyrimidin-2-yl]piperidin-4-yl}acetate;

methyl amino {1-[4-(2-naphthyl)pyrimidin-2-yl]piperidin-4-yl}acetate;

methyl (2R)-amino {1-[4-(2-naphthyl)pyrimidin-2-yl]piperidin-4-yl}acetate;

methyl (2S)-amino {1-[4-(2-naphthyl)pyrimidin-2-yl]piperidin-4-yl}acetate;

(2R)-2-amino-2-{1-[4-(2-naphthyl)pyrimidin-2-yl]piperidin-4-yl}ethanol;

tert-butyl ((1R)-2-hydroxy-1-{1-[4-(2-naphthyl)pyrimidin-2-yl]piperidin-4-yl}ethyl)carbamate;

tert-butyl ((1S)-2-hydroxy-1-{1-[4-(2-naphthyl)pyrimidin-2-yl]piperidin-4-yl}ethyl)carbamate;

tert-butyl ((1R)-2-hydroxy-2-methyl-1-{1-[4-(2-naphthyl)pyrimidin-2-yl]piperidin-4-yl}propyl)carbamate;

(1R)-1-amino-2-methyl-1-{1-[4-(2-naphthyl)pyrimidin-2-yl]piperidin-4yl}propan-2-ol;

(4R)-5,5-dimethyl-4-{1-[4-(2-naphthyl)pyrimidin-2-yl]piperidin-4-yl}-1,3-oxazolidin-2-one;

(4R)-4-{1-[4-(2-naphthyl)pyrimidin-2-yl]piperidin-4-yl}-1,3-oxazolidin-2-one; or

(1-(4-(naphthalen-2-yl)pyrimidin-2-yl)piperidin-4-yl)methanol.

32 . The compound of claim 30 , or a pharmaceutically acceptable salt thereof, wherein the compound is

N-[4-(2-naphthyl)pyrimidin-2-yl]azepan-4-amine;

tert-butyl 3-({[4-(2-naphthyl)pyrimidin-2-yl]amino }methyl)azetidine-1-carboxylate;

N-(azetidin-3-ylmethyl)-4-(2-naphthyl)pyrimidin-2-amine;

tert-butyl (3S)-3-({[4-(2-naphthyl)pyrimidin-2-yl]amino }methyl)pyrrolidine-1-carboxylate;

4-(2-naphthyl)-N-[(3R)-pyrrolidin-3-ylmethyl]pyrimidin-2-amine;

N-(2-morpholin-4-ylethyl)-4-(2-naphthyl)pyrimidin-2-amine;

N-(3-morpholin-4-ylpropyl)-4-(2-naphthyl)pyrimidin-2-amine;

4-(2-naphthyl)-N-(pyridin-3-ylmethyl)pyrimidin-2-amine;

4-(2-naphthyl)-N-(pyridin-4-ylmethyl)pyrimidin-2-amine;

4-(2-naphthyl)-N-(pyridin-2-ylmethyl)pyrimidin-2-amine;

4-({[4-(2-naphthyl)pyrimidin-2-yl]amino }methyl)benzenesulfonamide;

4-(2-naphthyl)-N-(2-pyridin-3-ylethyl)pyrimidin-2-amine;

4-(2-naphthyl)-N-(2-pyridin-4-ylethyl)pyrimidin-2-amine;

tert-butyl (3S)-3-{[4-(2-naphthyl)pyrimidin-2-yl]amino}pyrrolidine-1-carboxylate;

tert-butyl (3R)-3-{[4-(2-naphthyl)pyrimidin-2-yl]amino}pyrrolidine-1-carboxylate;

4-(2-naphthyl)-N-[(3S)-pyrrolidin-3-yl]pyrimidin-2-amine;

4-(2-naphthyl)-N-[(3R)-pyrrolidin-3-yl]pyrimidin-2-amine;

tert-butyl (3R)-3-({[4-(2-naphthyl)pyrimidin-2-yl]amino }methyl)pyrrolidine-1-carboxylate;

4-(2-naphthyl)-N-[(3S)-pyrrolidin-3-ylmethyl]pyrimidin-2-amine;

4-(2-naphthyl)-N-(piperidin-4-ylmethyl)pyrimidin-2-amine;

tert-butyl 4-({[4-(2-naphthyl)pyrimidin-2-yl]amino }methyl)piperidine-1-carboxylate;

trans-N-[4-(2-naphthyl)pyrimidin-2-yl]cyclohexane-1,4-diamine;

N-(4-methoxybenzyl)-4-(2-naphthyl)pyrimidin-2-amine;

N-[2-(4-methylphenyl)ethyl]-4-(2-naphthyl)pyrimidin-2-amine;

2-{methyl[4-(2-naphthyl)pyrimidin-2-yl]amino}ethanol;

N-(2-methoxyethyl)-4-(2-naphthyl)pyrimidin-2-amine;

2-{[4-(2-naphthyl)pyrimidin-2-yl]amino }ethanol;

N-(2-methoxyethyl)-N-methyl-4-(2-naphthyl)pyrimidin-2-amine;

N-methyl-4-(2-naphthyl)pyrimidin-2-amine;

N,N-diethyl-4-(2-naphthyl)pyrimidin-2-amine;

4-(2-naphthyl)-N-propylpyrimidin-2-amine;

N-butyl-4-(2-naphthyl)pyrimidin-2-amine;

N-isopropyl-4-(2-naphthyl)pyrimidin-2-amine;

N-(sec-butyl)-4-(2-naphthyl)pyrimidin-2-amine;

N-isobutyl-4-(2-naphthyl)pyrimidin-2-amine;

N-(tert-butyl)-4-(2-naphthyl)pyrimidin-2-amine;

N-benzyl-4-(2-naphthyl)pyrimidin-2-amine;

4-(2-naphthyl)-N-(2-phenylethyl)pyrimidin-2-amine;

N-cyclopentyl-4-(2-naphthyl)pyrimidin-2-amine;

N-cyclohexyl-4-(2-naphthyl)pyrimidin-2-amine;

tert-butyl 4-{[4-(2-naphthyl)pyrimidin-2-yl]amino}piperidine-1-carboxylate;

4-(2-naphthyl)-N-piperidin-4-ylpyrimidin-2-amine;

tert-butyl 4- {methyl[4-(2-naphthyl)pyrimidin-2-yl]amino}piperidine-1-carboxylate;

N-methyl-4-(2-naphthyl)-N-piperidin-4-ylpyrimidin-2-amine;

tert-butyl 4-(2-methoxy-1-{[4-(2-naphthyl)pyrimidin-2-yl]amino}-2-oxoethyl)piperidine-1-carboxylate;

4-{methyl[4-(2-naphthyl)pyrimidin-2-yl]amino}piperidine-1-carbaldehyde;

N-(1-benzylpiperidin-4-yl)-N-methyl-4-(2-naphthyl)pyrimidin-2-amine;

N-[(1-acetylazetidin-3-yl)methyl]-4-(2-naphthyl)pyrimidin-2-amine;

4-(2-naphthyl)-N-{[1-(trifluoroacetyl)azetidin-3-yl]methyl}pyrimidin-2-amine;

N-[(1-benzoylazetidin-3-yl)methyl]-4-(2-naphthyl)pyrimidin-2-amine;

3-({[4-(2-naphthyl)pyrimidin-2-yl]amino}methyl)azetidine-1-carboxamide;

N-ethyl-3-({[4-(2-naphthyl)pyrimidin-2-yl]amino}methyl)azetidine-1-carboxamide;

N-{[1-(methylsulfonyl)azetidin-3-yl]methyl}-4-(2-naphthyl)pyrimidin-2-amine;

N-({1-[(4-methylphenyl)sulfonyl]azetidin-3-yl}methyl)-4-(2-naphthyl)pyrimidin-2-amine;

N,N-dimethyl-3-({[4-(2-naphthyl)pyrimidin-2-yl]amino}methyl)azetidine-1-sulfonamide;

N-[(3S)-1-acetylpyrrolidin-3-yl]-4-(2-naphthyl)pyrimidin-2-amine;

N-[(3S)-1-benzoylpyrrolidin-3-yl]-4-(2-naphthyl)pyrimidin-2-amine;

methyl (3S)-3-{[4-(2-naphthyl)pyrimidin-2-yl]amino}pyrrolidine-1-carboxylate;

(3S)-N,N-dimethyl-3-{[4-(2-naphthyl)pyrimidin-2-yl]amino}pyrrolidine-1-carboxamide;

(3S)-N-ethyl-3-{[4-(2-naphthyl)pyrimidin-2-yl]amino}pyrrolidine-1-carboxamide;

(3S)-3-{[4-(2-naphthyl)pyrimidin-2-yl]amino}pyrrolidine-1-carboxamide;

(3S)-N,N-dimethyl-3-{[4-(2-naphthyl)pyrimidin-2-yl]amino}pyrrolidine-1-sulfonamide;

N-[(3S)-1-(methylsulfonyl)pyrrolidin-3-yl]-4-(2-naphthyl)pyrimidin-2-amine;

N-{(3S)-1-[(4-methylphenyl)sulfonyl]pyrrolidin-3-yl}-4-(2-naphthyl)pyrimidin-2-amine;

(3S)-3-{[4-(2-naphthyl)pyrimidin-2-yl]amino}pyrrolidine-1-carbaldehyde;

N-[(3S)-1-(morpholin-4-ylcarbonyl)pyrrolidin-3-yl]-4-(2-naphthyl)pyrimidin-2-amine;

ethyl (3S)-3-{[4-(2-naphthyl)pyrimidin-2-yl]amino}pyrrolidine-1-carboxylate;

N-[(3R)-1-acetylpyrrolidin-3-yl]-4-(2-naphthyl)pyrimidin-2-amine;

N-[(3R)-1-benzoylpyrrolidin-3-yl]-4-(2-naphthyl)pyrimidin-2-amine;

methyl (3R)-3-{[4-(2-naphthyl)pyrimidin-2-yl]amino}pyrrolidine-1-carboxylate;

(3R)-N,N-dimethyl-3-{[4-(2-naphthyl)pyrimidin-2-yl]amino}pyrrolidine-1-carboxamide;

(3R)-N-ethyl-3-{[4-(2-naphthyl)pyrimidin-2-yl]amino}pyrrolidine-1-carboxamide;

(3R)-3-{[4-(2-naphthyl)pyrimidin-2-yl]amino}pyrrolidine-1-carboxamide;

(3R)-N,N-dimethyl-3-{[4-(2-naphthyl)pyrimidin-2-yl]amino}pyrrolidine-1-sulfonamide;

N-[(3R)-1-(methylsulfonyl)pyrrolidin-3-yl]-4-(2-naphthyl)pyrimidin-2-amine;

N-{(3R)-1-[(4-methylphenyl)sulfonyl]pyrrolidin-3-yl}-4-(2-naphthyl)pyrimidin-2-amine;

(3R)-3-{[4-(2-naphthyl)pyrimidin-2-yl]amino}pyrrolidine-1-carbaldehyde;

N-[(3R)-1-(morpholin-4-ylcarbonyl)pyrrolidin-3-yl]-4-(2-naphthyl)pyrimidin-2-amine;

ethyl (3R)-3-{[4-(2-naphthyl)pyrimidin-2-yl]amino}pyrrolidine-1-carboxylate;

N-{[(3R)-1-acetylpyrrolidin-3-yl]methyl}-4-(2-naphthyl)pyrimidin-2-amine;

methyl (3R)-3-({[4-(2-naphthyl)pyrimidin-2-yl]amino}methyl)pyrrolidine-1-carboxylate;

(3R)-3-({[4-(2-naphthyl)pyrimidin-2-yl]amino}methyl)pyrrolidine-1-carbaldehyde;

N-{[(3S)-1-acetylpyrrolidin-3-yl]methyl}-4-(2-naphthyl)pyrimidin-2-amine;

methyl (3S)-3-({[4-(2-naphthyl)pyrimidin-2-yl]amino}methyl)pyrrolidine-1-carboxylate;

(3S)-3-({[4-(2-naphthyl)pyrimidin-2-yl]amino}methyl)pyrrolidine-1-carbaldehyde;

N-[(1-acetylpiperidin-4-yl)methyl]-4-(2-naphthyl)pyrimidin-2-amine;

N,N-dimethyl-4-({[4-(2-naphthyl)pyrimidin-2-yl]amino}methyl)piperidine-1-carboxamide;

N,N-diethyl-4-({[4-(2-naphthyl)pyrimidin-2-yl]amino}methyl)piperidine-1-carboxamide;

4-(2-naphthyl)-N-{[1-(pyrrolidin-1-ylcarbonyl)piperidin-4-yl]methyl}pyrimidin-2-amine;

N-{[1-(methylsulfonyl)piperidin-4-yl]methyl}-4-(2-naphthyl)pyrimidin-2-amine;

N,N-dimethyl-4-({[4-(2-naphthyl)pyrimidin-2-yl]amino}methyl)piperidine-1-sulfonamide;

4-({[4-(2-naphthyl)pyrimidin-2-yl]amino}methyl)piperidine-1-carboxamide;

N-ethyl-4-({[4-(2-naphthyl)pyrimidin-2-yl]amino}methyl)piperidine-1-carboxamide;

N-isopropyl-4-({[4-(2-naphthyl)pyrimidin-2-yl]amino}methyl)piperidine-1-carboxamide;

N-cyclohexyl-4-({[4-(2-naphthyl)pyrimidin-2-yl]amino}methyl)piperidine-1-carboxamide;

N-[(1-benzoylpiperidin-4-yl)methyl]-4-(2-naphthyl)pyrimidin-2-amine;

N-[(1-ethylpiperidin-4-yl)methyl]-4-(2-naphthyl)pyrimidin-2-amine;

N-[(1-benzylpiperidin-4-yl)methyl]-4-(2-naphthyl)pyrimidin-2-amine;

4-(2-naphthyl)-N-{[1-(phenylacetyl)piperidin-4-yl]methyl}pyrimidin-2-amine;

N-({1-[(4-methylphenyl)sulfonyl]piperidin-4-yl}methyl)-4-(2-naphthyl)pyrimidin-2-amine;

N-(trans-4-{[4-(2-naphthyl)pyrimidin-2-yl]amino}cyclohexyl)acetamide;

methyl (trans-4-{[4-(2-naphthyl)pyrimidin-2-yl]amino}cyclohexyl)carbamate;

N,N-dimethyl-N′-(trans-4-{[4-(2-naphthyl)pyrimidin-2-yl]amino}cyclohexyl)urea;

N-ethyl-N′-(trans-4-{[4-(2-naphthyl)pyrimidin-2-yl]amino}cyclohexyl)urea;

N,N-dimethyl-N′-(trans-4-{[4-(2-naphthyl)pyrimidin-2-yl]amino}cyclohexyl)sulfamide;

N-(trans-4-{[4-(2-naphthyl)pyrimidin-2-yl]amino}cyclohexyl)methanesulfonamide;

4-methyl-N-(trans-4-{[4-(2-naphthyl)pyrimidin-2-yl]amino}cyclohexyl)benzenesulfonamide;

5-(dimethylamino)-N-(trans-4-{[4-(2-naphthyl)pyrimidin-2-yl]amino}cyclohexyl)naphthalene-1-sulfonamide;

4-cyano-N-(3-{[4-(2-naphthyl)pyrimidin-2-yl]amino}cyclohexyl)benzamide;

N-(1-acetylpiperidin-4-yl)-4-(2-naphthyl)pyrimidin-2-amine;

N,N-dimethyl-4-{[4-(2-naphthyl)pyrimidin-2-yl]amino}piperidine-1-carboxamide;

N,N-diethyl-4-{[4-(2-naphthyl)pyrimidin-2-yl]amino}piperidine-1-carboxamide;

4-(2-naphthyl)-N-[1-(pyrrolidin-1-ylcarbonyl)piperidin-4-yl]pyrimidin-2-amine;

N-[1-(morpholin-4-ylcarbonyl)piperidin-4-yl]-4-(2-naphthyl)pyrimidin-2-amine;

N-[1-(methylsulfonyl)piperidin-4-yl]-4-(2-naphthyl)pyrimidin-2-amine;

N,N-dimethyl-4-{[4-(2-naphthyl)pyrimidin-2-yl]amino}piperidine-1-sulfonamide;

4-{[4-(2-naphthyl)pyrimidin-2-yl]amino}piperidine-1-carboxamide;

N-ethyl-4-{[4-(2-naphthyl)pyrimidin-2-yl]amino}piperidine-1-carboxamide;

N-isopropyl-4-{[4-(2-naphthyl)pyrimidin-2-yl]amino}piperidine-1-carboxamide;

N-cyclohexyl-4-{[4-(2-naphthyl)pyrimidin-2-yl]amino}piperidine-1-carboxamide;

N-(1-benzoylpiperidin-4-yl)-4-(2-naphthyl)pyrimidin-2-amine;

N-(1-acetylpiperidin-4-yl)-N-methyl-4-(2-naphthyl)pyrimidin-2-amine;

N-methyl-4-(2-naphthyl)-N-[1-(trifluoroacetyl)piperidin-4-yl]pyrimidin-2-amine;

N-(1-benzoylpiperidin-4-yl)-N-methyl-4-(2-naphthyl)pyrimidin-2-amine;

methyl 4-{methyl[4-(2-naphthyl)pyrimidin-2-yl]amino}piperidine-1-carboxylate;

N,N-dimethyl-4-{methyl[4-(2-naphthyl)pyrimidin-2-yl]amino}piperidine-1-carboxamide;

N-methyl-4-(2-naphthyl)-N-[1-(pyrrolidin-1-ylcarbonyl)piperidin-4-yl]pyrimidin-2-amine;

N,N-diethyl-4-{methyl[4-(2-naphthyl)pyrimidin-2-yl]amino}piperidine-1-carboxamide;

N-ethyl-4-{methyl[4-(2-naphthyl)pyrimidin-2-yl]amino}piperidine-1-carboxamide;

4-{methyl[4-(2-naphthyl)pyrimidin-2-yl]amino}piperidine-1-carboxamide;

N-methyl-N-[1-(methylsulfonyl)piperidin-4-yl]-4-(2-naphthyl)pyrimidin-2-amine;

N-methyl-N-{1-[(4-methylphenyl)sulfonyl]piperidin-4-yl}-4-(2-naphthyl)pyrimidin-2-amine;

N-methyl-4-(2-naphthyl)-N-(1-pyrimidin-2-ylpiperidin-4-yl)pyrimidin-2-amine;

N-methyl-4-(2-naphthyl)-N-(1-propylpiperidin-4-yl)pyrimidin-2-amine;

2-(4-{methyl[4-(2-naphthyl)pyrimidin-2-yl]amino}piperidin-1-yl)acetamide;

N-methyl-4-(2-naphthyl)-N-{1-[2-(trityloxy)ethyl]piperidin-4-yl}pyrimidin-2-amine;

4-{methyl[4-(2-naphthyl)pyrimidin-2-yl]amino}piperidine-1-carboximidamide;

tert-butyl (3-{[4-(2-naphthyl)pyrimidin-2-yl]amino}cyclohexyl)carbamate; or

4-(2-naphthyl)-2-[4-(pyrrolidin-1-ylmethyl)piperidin-1-yl]pyrimidine.

33 . A compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein the compound is:

1-{1-[2-(2-naphthyl)pyrimidin-4-yl]piperidin-4-yl}methanamine;

1-{1-[6-(2-naphthyl)pyrimidin-4-yl]piperidin-4-yl}methanamine;

1-{1-[5-(2-naphthyl)pyrimidin-2-yl]piperidin-4-yl}methanamine;

1-{1-[6-(2-naphthyl)pyrazin-2-yl]piperidin-4-yl}methanamine;

1-{1-[5-(2-naphthyl)pyridazin-3-yl]piperidin-4-yl}methanamine;

1-{1-[4-(2-naphthyl)pyrimidin-2-yl]-1,2,3,4-tetrahydroquinolin-4-yl}methanamine;

1-{(4S)-1-[4-(2-naphthyl)pyrimidin-2-yl]azepan-4-yl}methanamine;

1-{(4R) 1-[4-(2-naphthyl)pyrimidin-2-yl]azepan-4-yl}methanamine;

1-[4-(2-naphthyl)pyrimidin-2-yl]azepan-4-amine;

N-{1-[4-(2-naphthyl)pyrimidin-2-yl]azepan-4-yl}acetamide;

2,2,2-trifluoro-N-{1-[4-(2-naphthyl)pyrimidin-2-yl]azepan-4-yl}acetamide;

N,N-dimethyl-N′-{1-[4-(2-naphthyl)pyrimidin-2-yl]azepan-4-yl}urea;

N-{1-[4-(2-naphthyl)pyrimidin-2-yl]azepan-4-yl}benzamide;

N-{1-[4-(2-naphthyl)pyrimidin-2-yl]azepan-4-yl}urea;

N-ethyl-N′-{1-[4-(2-naphthyl)pyrimidin-2-yl]azepan-4-yl}urea;

N-{1-[4-(2-naphthyl)pyrimidin-2-yl]azepan-4-yl}methanesulfonamide;

4-methyl-N-{1-[4-(2-naphthyl)pyrimidin-2-yl]azepan-4-yl}benzenesulfonamide;

N,N-dimethyl-N′-{1-[4-(2-naphthyl)pyrimidin-2-yl]azepan-4-yl}sulfamide;

{(1S,4R)-2-[4-(2-naphthyl)pyrimidin-2-yl]-2-azabicyclo[2.2.1]heptane-5,5-diyl}dimethanamine;

1-{(1R,4R,5R)-2-[4-(2-naphthyl)pyrimidin-2-yl]-2-azabicyclo[2.2.1]hept-5-yl}methanamine;

1-{(1R,4R,5S)-2-[4-(2-naphthyl)pyrimidin-2-yl]-2-azabicyclo[2.2.1]hept-5-yl}methanamine;

1-{(1S,4S,5S)-2-[4-(2-naphthyl)pyrimidin-2-yl]-2-azabicyclo[2.2.1]hept-5-yl}methanamine;

1-{(1S,4S,5R)-2-[4-(2-naphthyl)pyrimidin-2-yl]-2-azabicyclo[2.2.1]hept-5-yl}methanamine;

1-{8-[4-(2-naphthyl)pyrimidin-2-yl]-8-azabicyclo[3.2.1]oct-3-yl}methanamine;

1-{8-[4-(2-naphthyl)pyrimidin-2-yl]-8-azabicyclo[3.2.1]oct-3-yl}methanamine;

2-[4-(2-naphthyl)pyrimidin-2-yl]-2, 8-diazaspiro[4.5]decane;

N,N,N′-trimethyl-N′-{(3R)-1-[4-(2-naphthyl)pyrimidin-2-yl]pyrrolidin-3-yl}ethane-1,2-diamine;

(3aR* ,6aS)-2-[4-(2-naphthyl)pyrimidin-2-yl]octahydropyrrolo[3,4-c]pyrrole;

5-(4-naphthalen-2-ylpyrimidin-2-yl)octahydropyrrolo [3,4-b]pyrrole;

1-({1-[4-(2-naphthyl)pyrimidin-2-yl]pyrrolidin-3-yl}methyl)piperidin-4-ol;

(3S)-1-({1-[4-(2-naphthyl)pyrimidin-2-yl]pyrrolidin-3-yl}methyl)piperidin-3-ol;

(3R)-1-({1-[4-(2-naphthyl)pyrimidin-2-yl]pyrrolidin-3-yl}methyl)piperidin-3-ol;

(3S)-1-({1-[4-(2-naphthyl)pyrimidin-2-yl]pyrrolidin-3-yl}methyl)pyrrolidin-3-ol;

(3R)-1-({1-[4-(2-naphthyl)pyrimidin-2-yl]pyrrolidin-3-yl}methyl)pyrrolidin-3-ol;

(3S,3′R)-1′-[4-(2-naphthyl)pyrimidin-2-yl]-1,3′-bipyrrolidin-3-ol;

2-{(3R)-1-[4-(2-naphthyl)pyrimidin-2-yl]pyrrolidin-3-yl}octahydro-2H-pyrido[1,2-a]pyrazine;

(3S,3′R)-1′-[4-(2-naphthyl)pyrimidin-2-yl]-1,3′-bipyrrolidin-3-amine;

3-(methyl {(3R)-1-[4-(2-naphthyl)pyrimidin-2-yl]pyrrolidin-3-yl}amino)propan-1-ol;

N,N-dimethyl-N′-{(3R)-1-[4-(2-naphthyl)pyrimidin-2-yl]pyrrolidin-3-yl}ethane-1,2-diamine;

N,N′-dimethyl-N-{(3R)-1-[4-(2-naphthyl)pyrimidin-2-yl]pyrrolidin-3-yl}ethane-1,2-diamine;

(3R,3′R)-1′-[4-(2-naphthyl)pyrimidin-2-yl]-1,3′-bipyrrolidin-3-ol;

(3R,3′R)-1′-[4-(2-naphthyl)pyrimidin-2-yl]-1,3′-bipyrrolidin-3-amine;

(1S,4S)-2-methyl-5-{(3R)-1-[4-(2-naphthyl)pyrimidin-2-yl]pyrrolidin-3-yl}-2,5-diazabicyclo[2.2.1]heptane;

5-{(3R)-1-[4-(2-naphthyl)pyrimidin-2-yl]pyrrolidin-3-yl}octahydropyrrolo[3,4b]-pyrrole;

N,N,N′-trimethyl-N′-{(3R)-1-[4-(2-naphthyl)pyrimidin-2-yl]pyrrolidin-3-yl}propane-1,3-diamine;

(3R,3′S)-1′-[4-(2-naphthyl)pyrimidin-2-yl]-1,3′-bipyrrolidin-3-ol;

(3S,3′S)-1′-[4-(2-naphthyl)pyrimidin-2-yl]-1,3′-bipyrrolidin-3-ol;

N,N-dimethyl-N′-{(3S)-1-[4-(2-naphthyl)pyrimidin-2-yl]pyrrolidin-3-yl}ethane-1,2-diamine;

N,N,N′-trimethyl-N′-{(3S)-1-[4-(2-naphthyl)pyrimidin-2-yl]pyrrolidin-3-yl}ethane-1,2-diamine

3-(methyl{(3S)-1-[4-(2-naphthyl)pyrimidin-2-yl]pyrrolidin-3-yl}amino)propan-1-ol;

5-{(3S)-1-[4-(2-naphthyl)pyrimidin-2-yl]pyrrolidin-3-yl}octahydropyrrolo[3,4-b]pyrrole;

N,N,N′-trimethyl-N′-{(3S)-1-[4-(2-naphthyl)pyrimidin-2-yl]pyrrolidin-3-yl}propane-1,3-diamine;

2-(ethyl{(3S)-1-[4-(2-naphthyl)pyrimidin-2-yl]pyrrolidin-3-yl}amino)ethanol;

2-[(3S)-3-(1H-imidazol-1-yl)pyrrolidin-1-yl]-4-(2-naphthyl)pyrimidine;

(3S)-N-cyclohexyl-N-methyl-1-[4-(2-naphthyl)pyrimidin-2-yl]pyrrolidin-3-amine;

(3S)-N-(tert-butyl)-1-[4-(2-naphthyl)pyrimidin-2-yl]pyrrolidin-3-amine;

4-(2-naphthyl)-2-[(3S)-3-piperazin-1-ylpyrrolidin-1-yl]pyrimidine;

4-{(3S)-1-[4-(2-naphthyl)pyrimidin-2-yl]pyrrolidin-3-yl}morpholine;

4-{(3S)-1-[4-(2-naphthyl)pyrimidin-2-yl]pyrrolidin-3-yl}piperazin-2-one;

1-{(3S)-1-[4-(2-naphthyl)pyrimidin-2-yl]pyrrolidin-3-yl}azepane;

(3′S)-1′-[4-(2-naphthyl)pyrimidin-2-yl]-1,3′-bipyrrolidine;

4-(2-naphthyl)-2-[(3S)-3-piperidin-1-ylpyrrolidin-1-yl]pyrimidine;

2-[(3S)-3-(4-methylpiperazin-1-yl)pyrrolidin-1-yl]-4-(2-naphthyl)pyrimidine;

(1-{(3S)-1-[4-(2-naphthyl)pyrimidin-2-yl]pyrrolidin-3-yl}piperidin-3-yl)methanol;

(1-{(3S)-1-[4-(2-naphthyl)pyrimidin-2-yl]pyrrolidin-3-yl}piperidin-4-yl)methanol;

1-{(3S)-1-[4-(2-naphthyl)pyrimidin-2-yl]pyrrolidin-3-yl}piperidin-3-ol;

(3S)-N-(2-morpholin-4-ylethyl)-1-[4-(2-naphthyl)pyrimidin-2-yl]pyrrolidin-3-amine;

1-{(3S)-1-[4-(2-naphthyl)pyrimidin-2-yl]pyrrolidin-3-yl}piperidin-4-ol;

(3R,3′S)-N,N-dimethyl-1′-[4-(2-naphthyl)pyrimidin-2-yl]-1,3′-bipyrrolidin-3-amine;

(3S,3′S)-N,N-dimethyl-1′-[4-(2-naphthyl)pyrimidin-2-yl]-1,3′-bipyrrolidin-3-amine;

(3R)-1-{(3S)-1-[4-(2-naphthyl)pyrimidin-2-yl]pyrrolidin-3-yl}piperidin-3-ol;

(3S)-1-{(3S)-1-[4-(2-naphthyl)pyrimidin-2-yl]pyrrolidin-3-yl}piperidin-3ol;

2-(ethyl{(3R)-1-[4-(2-naphthyl)pyrimidin-2-yl]pyrrolidin-3-yl}amino)ethanol;

2-[(3R)-3-(1H-imidazol-1-yl)pyrrolidin-1-yl]-4-(2-naphthyl)pyrimidine;

(3R)-N-cyclohexyl-N-methyl-1-[4-(2-naphthyl)pyrimidin-2-yl]pyrrolidin-3-amine;

(3R)-N-(tert-butyl)-1-[4-(2-naphthyl)pyrimidin-2-yl]pyrrolidin-3-amine;

4-(2-naphthyl)-2-[(3R)-3-piperazin-1-ylpyrrolidin-1-yl]pyrimidine;

4-{(3R)-1-[4-(2-naphthyl)pyrimidin-2-yl]pyrrolidin-3-yl}morpholine;

4-{(3R)-1-[4-(2-naphthyl)pyrimidin-2-yl]pyrrolidin-3-yl}piperazin-2-one;

1-{(3R)-1-[4-(2-naphthyl)pyrimidin-2-yl]pyrrolidin-3-yl}azepane;

(3′R)-1′-[4-(2-naphthyl)pyrimidin-2-yl]-1,3′-bipyrrolidine;

4-(2-naphthyl)-2-[(3R)-3-piperidin-1-ylpyrrolidin-1-yl]pyrimidine;

2-[(3R)-3-(4-methylpiperazin-1-yl)pyrrolidin-1-yl]-4-(2-naphthyl)pyrimidine;

(1-{(3R)-1-[4-(2-naphthyl)pyrimidin-2-yl]pyrrolidin-3-yl}piperidin-3-yl)methanol;

(1-{(3R)-1-[4-(2-naphthyl)pyrimidin-2-yl]pyrrolidin-3-yl}piperidin-4-yl)methanol;

1-{(3R)-1-[4-(2-naphthyl)pyrimidin-2-yl]pyrrolidin-3-yl}piperidin-3-ol;

(3R)-N-(2-morpholin-4-ylethyl)-1-[4-(2-naphthyl)pyrimidin-2-yl]pyrrolidin-3-amine;

1-{(3R)-1-[4-(2-naphthyl)pyrimidin-2-yl]pyrrolidin-3-yl}piperidin-4-ol;

(3R,3′R)-N,N-dimethyl-1′-[4-(2-naphthyl)pyrimidin-2-yl]-1,3′-bipyrrolidin-3-amine;

(3S,3′R)-N,N-dimethyl-1′-[4-(2-naphthyl)pyrimidin-2-yl]-1,3′-bipyrrolidin-3-amine;

(3R)-1-{(3R)-1-[4-(2-naphthyl)pyrimidin-2-yl]pyrrolidin-3-yl}piperidin-3-ol;

(3S)-1-{(3R)-1-[4-(2-naphthyl)pyrimidin-2-yl]pyrrolidin-3-yl}piperidin-3-ol;

{1-[4-(2-naphthyl)pyrimidin-2-yl]pyrrolidin-3-yl}methanol;

1-({1-[4-(2-naphthyl)pyrimidin-2-yl]pyrrolidin-3-yl}methyl)azepane;

4-(2-naphthyl)-2-[3-(piperidin-1-ylmethyl)pyrrolidin-1-yl]pyrimidine;

4-(2-naphthyl)-2-[3-(pyrrolidin-1-ylmethyl)pyrrolidin-1-yl]pyrimidine;

2-[3-(azetidin-1-ylmethyl)pyrrolidin-1-yl]-4-(2-naphthyl)pyrimidine;

4-({1-[4-(2-naphthyl)pyrimidin-2-yl]pyrrolidin-3-yl}methyl)morpholine;

4-({1-[4-(2-naphthyl)pyrimidin-2-yl]pyrrolidin-3-yl}methyl)thiomorpholine;

N-ethyl-N-({1-[4-(2-naphthyl)pyrimidin-2-yl]pyrrolidin-3-yl}methyl)ethanamine;

2-methyl-N-({1-[4-(2-naphthyl)pyrimidin-2-yl]pyrrolidin-3-yl}methyl)propan-2-amine;

2-[ethyl({1-[4-(2-naphthyl)pyrimidin-2-yl]pyrrolidin-3-yl}methyl) amino]ethanol;

2-{3-[(4-methylpiperazin-1-yl)methyl]pyrrolidin-1-yl}-4-(2-naphthyl)pyrimidine;

4-({1-[4-(2-naphthyl)pyrimidin-2-yl]pyrrolidin-3-yl}methyl)piperazin-2-one;

2-[3-(1H-imidazol-1-ylmethyl)pyrrolidin-1-yl]-4-(2-naphthyl)pyrimidine;

2-[3-(chloromethyl)pyrrolidin-1-yl]-4-(2-naphthyl)pyrimidine;

N,N-dimethyl-1-{(3S)-1-[4-(2-naphthyl)pyrimidin-2-yl]pyrrolidin-3-yl}methanamine;

4-(2-naphthyl)-2-[(3S)-3-(piperidin-1-ylmethyl)pyrrolidin-1-yl]pyrimidine;

4-(2-naphthyl)-2-[(3S)-3-(pyrrolidin-1-ylmethyl)pyrrolidin-1-yl]pyrimidine;

N-methyl-1-{(3S)-1-[4-(2-naphthyl)pyrimidin-2-yl]pyrrolidin-3-yl}methanamine;

N-methyl-N-({(3S)-1-[4-(2-naphthyl)pyrimidin-2-yl]pyrrolidin-3-yl}methyl)cyclohexanamine;

1-({(3R)-1-[4-(2-naphthyl)pyrimidin-2-yl]pyrrolidin-3-yl}methyl)piperidin-2-one;

tert-butyl 4-({(3S)-1-[4-(2-naphthyl)pyrimidin-2-yl]pyrrolidin-3-yl}methyl)piperazine-1-carboxylate;

2-methyl-N-({(3S)-1-[4-(2-naphthyl)pyrimidin-2-yl]pyrrolidin-3-yl}methyl)propan-2-amine;

2-[ethyl({(3S)-1-[4-(2-naphthyl)pyrimidin-2-yl]pyrrolidin-3-yl}methyl)amino]ethanol;

2-{(3S)-3-[(4-methylpiperazin-1-yl)methyl]pyrrolidin-1-yl}-4-(2-naphthyl)pyrimidine;

(3S)-N,N-dimethyl-1-({(3S)-1-[4-(2-naphthyl)pyrimidin-2-yl]pyrrolidin-3-yl}methyl)pyrrolidin-3-amine;

2-[(3R)-3-(1H-imidazol-1-ylmethyl)pyrrolidin-1-yl]-4-(2-naphthyl)pyrimidine;

(3R)-N,N-dimethyl-1-({(3S)-1-[4-(2-naphthyl)pyrimidin-2-yl]pyrrolidin-3-yl}methyl)pyrrolidin-3-amine;

N,N-dimethyl-1-{(3R)-1-[4-(2-naphthyl)pyrimidin-2-yl]pyrrolidin-3-yl}methanamine;

4-(2-naphthyl)-2-[(3R)-3-(piperidin-1-ylmethyl)pyrrolidin-1-yl]pyrimidine;

4-(2-naphthyl)-2-[(3R)-3-(pyrrolidin-1-ylmethyl)pyrrolidin-1-yl]pyrimidine;

N-methyl-1-{(3R)-1-[4-(2-naphthyl)pyrimidin-2-yl]pyrrolidin-3-yl}methanamine;

N-methyl-N-({(3R)-1-[4-(2-naphthyl)pyrimidin-2-yl]pyrrolidin-3-yl}methyl)cyclohexanamine;

1-({(3S)-1-[4-(2-naphthyl)pyrimidin-2-yl]pyrrolidin-3-yl}methyl)piperidin-2-one;

tert-butyl 4-({(3R)-1-[4-(2-naphthyl)pyrimidin-2-yl]pyrrolidin-3-yl}methyl)piperazine-1-carboxylate;

2-methyl-N-({(3R)-1-[4-(2-naphthyl)pyrimidin-2-yl]pyrrolidin-3-yl}methyl)propan-2-amine;

2-[ethyl({(3R)-1-[4-(2-naphthyl)pyrimidin-2-yl]pyrrolidin-3-yl}methyl)amino]ethanol;

2-{(3R)-3-[(4-methylpiperazin-1-yl)methyl]pyrrolidin-1-yl}-4-(2-naphthyl)pyrimidine;

(3S)-N,N-dimethyl-1-({(3R)-1-[4-(2-naphthyl)pyrimidin-2-yl]pyrrolidin-3-yl}methyl)pyrrolidin-3-amine;

2-[(3S)-3-(1H-imidazol-1-ylmethyl)pyrrolidin-1-yl]-4-(2-naphthyl)pyrimidine;

(3R)-N,N-dimethyl-1-({(3R)-1-[4-(2-naphthyl)pyrimidin-2-yl]pyrrolidin-3-yl}methyl)pyrrolidin-3-amine;

N,N-dimethyl-1-[4-(2-naphthyl)pyrimidin-2-yl]-L-prolinamide;

4-(2-naphthyl)-2-[(2S)-2-(piperidin-1-ylcarbonyl)pyrrolidin-1-yl]pyrimidine;

4-(2-naphthyl)-2-[(2S)-2-(pyrrolidin-1-ylcarbonyl)pyrrolidin-1-yl]pyrimidine;

N-tert-butyl-1-[4-(2-naphthyl)pyrimidin-2-yl]-L-prolinamide;

N-ethyl-N-(2-hydroxyethyl)-1-[4-(2-naphthyl)pyrimidin-2-yl]-L-prolinamide;

2-{(2S)-2-[(4-methylpiperazin-1-yl)carbonyl]pyrrolidin-1-yl}-4-(2-naphthyl)pyrimidine;

(3S)-N,N-dimethyl-1-{1-[4-(2-naphthyl)pyrimidin-2-yl]-L-prolyl}pyrrolidin-3-amine;

(3R)-N,N-dimethyl-1-{1-[4-(2-naphthyl)pyrimidin-2-yl]-L-prolyl}pyrrolidin-3-amine;

N,N-dimethyl-1-[4-(2-naphthyl)pyrimidin-2-yl]-D-prolinamide;

4-(2-naphthyl)-2-[(2R)-2-(piperidin-1-ylcarbonyl)pyrrolidin-1-yl]pyrimidine;

4-(2-naphthyl)-2-[(2R)-2-(pyrrolidin-1-ylcarbonyl)pyrrolidin-1-yl]pyrimidine;

N-methyl-1-[4-(2-naphthyl)pyrimidin-2-yl]-D-prolinamide;

N-tert-butyl-1-[4-(2-naphthyl)pyrimidin-2-yl]-D-prolinamide;

2-{(2R)-2-[(4-methylpiperazin-1-yl)carbonyl]pyrrolidin-1-yl}-4-(2-naphthyl)pyrimidine;

(3S)-N,N-dimethyl-1-{1-[4-(2-naphthyl)pyrimidin-2-yl]-D-prolyl}pyrrolidin-3-amine;

(3R)-N,N-dimethyl-1-{1-[4-(2-naphthyl)pyrimidin-2-yl]-D-prolyl}pyrrolidin-3-amine;

(3′S)-1′-[4-(2-naphthyl)pyrimidin-2-yl]-1,3′-bipyrrolidin-2-one;

(3′R)-1′-[4-(2-naphthyl)pyrimidin-2-yl]-1,3′-bipyrrolidin-2-one;

tert-butyl {(3S)-1-[4-(2-naphthyl)pyrimidin-2-yl]pyrrolidin-3-yl}carbamate;

2-[(3R)-3-methoxypyrrolidin-1-yl]-4-(2-naphthyl)pyrimidine;

2-[(3S)-3-methoxypyrrolidin-1-yl]-4-(2-naphthyl)pyrimidine;

2,2,2-trifluoro-N-(2-{(2S)-1-[4-(2-naphthyl)pyrimidin-2-yl]pyrrolidin-2-yl}ethyl)acetamide;

2,2,2-trifluoro-N-(2-{(2R)-1-[4-(2-naphthyl)pyrimidin-2-yl]pyrrolidin-2-yl}ethyl)acetamide;

(3R)-N-methyl-1-[4-(2-naphthyl)pyrimidin-2-yl]pyrrolidin-3-amine;

(3S)-N-methyl-1-[4-(2-naphthyl)pyrimidin-2-yl]pyrrolidin-3-amine;

(3R)-N,N-dimethyl-1-[4-(2-naphthyl)pyrimidin-2-yl]pyrrolidin-3-amine;

(3S)-1-[4-(2-naphthyl)pyrimidin-2-yl]-N-(2,2,2-trifluoroethyl)pyrrolidin-3-amine;

N-{(3S)-1-[4-(2-naphthyl)pyrimidin-2-yl]pyrrolidin-3-yl}-N-(2,2,2-trifluoroethyl)acetamide;

2-{(2R)-1-[4-(2-naphthyl)pyrimidin-2-yl]pyrrolidin-2-yl}ethanamine;

2-{(2S)-1-[4-(2-naphthyl)pyrimidin-2-yl]pyrrolidin-2-yl}ethanamine;

2-{1-[4-(2-naphthyl)pyrimidin-2-yl]pyrrolidin-3-yl}ethanamine;

N-methyl-N-{(3R)-1-[4-(2-naphthyl)pyrimidin-2-yl]pyrrolidin-3-yl}acetamide;

N-ethyl-N,N′-dimethyl-N′-{(3R)-1-[4-(2-naphthyl)pyrimidin-2-yl]pyrrolidin-3-yl}ethane-1,2-diamine;

N,N′-dimethyl-N-{(3R)-1-[4-(2-naphthyl)pyrimidin-2-yl]pyrrolidin-3-yl}-N′-propylethane-1,2-diamine;

N-isopropyl-N,N′-dimethyl-N′-{(3R)-1-[4-(2-naphthyl)pyrimidin-2-yl]pyrrolidin-3-yl}ethane-1,2-diamine;

N-benzyl-N,N′-dimethyl-N′-{(3R)-1-[4-(2-naphthyl)pyrimidin-2-yl]pyrrolidin-3-yl}ethane-1,2-diamine;

N-methyl-N-[2-(methyl{(3R)-1-[4-(2-naphthyl)pyrimidin-2-yl]pyrrolidin-3-yl}amino)ethyl]acetamide;

2,2,2-trifluoro-N-methyl-N-[2-(methyl{(3R)-1-[4-(2-naphthyl)pyrimidin-2-yl]pyrrolidin-3-yl}amino)ethyl]acetamide;

N-methyl-N-[2-(methyl{(3R)-1-[4-(2-naphthyl)pyrimidin-2-yl]pyrrolidin-3-yl}amino)ethyl]propanamide;

N,2-dimethyl-N-[2-(methyl{(3R)-1-[4-(2-naphthyl)pyrimidin-2-yl]pyrrolidin-3-yl}amino)ethyl]propanamide;

N-methyl-N-[2-(methyl{(3R)-1-[4-(2-naphthyl)pyrimidin-2-yl]pyrrolidin-3-yl}amino)ethyl]methanesulfonamide;

b 1 , 1 -diethyl-3-methyl-3-[2-(methyl{(3R)-1-[4-(2-naphthyl)pyrimidin-2-yl]pyrrolidine-3-yl}amino)ethyl]urea;

methyl methyl[2-(methyl{(3R)-1-[4-(2-naphthyl)pyrimidin-2-yl]pyrrolidin-3-yl}amino)ethyl]carbamate;

N-methyl-N-[2-(methyl{(3R)-1-[4-(2-naphthyl)pyrimidin-2-yl]pyrrolidin-3-yl}amino)ethyl]ethanesulfonamide;

N,N,N′-trimethyl-N′-[2-(methyl{(3R)-1-[4-(2-naphthyl)pyrimidin-2-yl]pyrrolidin-3-yl}amino)ethyl]sulfamide;

N-methyl-N-[2-(methyl{(3R)-1-[4-(2-naphthyl)pyrimidin-2-yl]pyrrolidin-3-yl}amino)ethyl]benzamide;

N-methyl-N-[2-(methyl{(3R)-1-[4-(2-naphthyl)pyrimidin-2-yl]pyrrolidin-3-yl}amino)ethyl]benzenesulfonamide;

tert-butyl ({1-[4-(2-naphthyl)pyrimidin-2-yl]azetidin-3-yl}methyl)carbamate;

1-{1-[4-(2-naphthyl)pyrimidin-2-yl]azetidin-3-yl}methanamine;

methyl ({1-[4-(2-naphthyl)pyrimidin-2-yl]azetidin-3-yl}methyl)carbamate;

2,2,2-trifluoro-N-({1-[4-(2-naphthyl)pyrimidin-2-yl]azetidin-3-yl}methyl)acetamide;

N,N-dimethyl-N′-({1-[4-(2-naphthyl)pyrimidin-2-yl]azetidin-3-yl}methyl)urea;

N-({1-[4-(2-naphthyl)pyrimidin-2-yl]azetidin-3-yl}methyl)urea;

N-ethyl-N′-({1-[4-(2-naphthyl)pyrimidin-2-yl]azetidin-3-yl}methyl)urea;

N-({1-[4-(2-naphthyl)pyrimidin-2-yl]azetidin-3-yl}methyl)methanesulfonamide;

4-methyl-N-({1-[4-(2-naphthyl)pyrimidin-2-yl]azetidin-3-yl}methyl)benzenesulfonamide;

tert-butyl {2-[1-(4-naphthalen-2-ylpyrimidin-2-yl)azetidin-3-yl]ethyl}carbamate;

2-[1-(4-naphthalen-2-ylpyrimidin-2-yl)azetidin-3-yl]ethanamine;

tert-butyl [(trans-4-{[4-(2-naphthyl)pyrimidin-2-yl]oxy}cyclohexyl)methyl]carbamate;

1-(trans-4-{[4-(2-naphthyl)pyrimidin-2-yl]oxy}cyclohexyl)methanamine;

tert-butyl ({cis-4-[(4-naphthalen-2-ylpyrimidin-2-yl)oxy]cyclohexyl}methyl)carbamate;

1-{cis-4-[(4-naphthalen-2-ylpyrimidin-2-yl)oxy]cyclohexyl}methanamine;

N-[trans-4-(aminomethyl)cyclohexyl]-N-methyl-4-(2-naphthyl)pyrimidin-2-amine;

benzyl [(cis-4-{methyl[4-(2-naphthyl)pyrimidin-2-yl]amino}cyclohexyl)methyl]carbamate;

N-[cis-4-(aminomethyl)cyclohexyl]-N-methyl-4-(2-naphthyl)pyrimidin-2-amine;

1-{4-[4-(2-naphthyl)pyrimidin-2-yl]phenyl}methanamine;

1-[trans-4-(4-naphthalen-2-ylpyrimidin-2-yl)cyclohexyl]methanamine;

1-{cis-4-[4-(2-naphthyl)pyrimidin-2-yl]cyclohexyl}methanamine;

1-{1-[4-(6-methoxy-2-naphthyl)pyrimidin-2-yl]piperidin-4-yl}methanamine;

1-{1-[4-(6-propoxy-2-naphthyl)pyrimidin-2-yl]piperidin-4-yl}methanamine;

1-{1-[4-(6-isobutoxy-2-naphthyl)pyrimidin-2-yl]piperidin-4-yl}methanamine;

6-{2-[4-(aminomethyl)piperidin-1-yl]pyrimidin-4-yl}-2-naphthyl acetate;

6-{2-[4-(aminomethyl)piperidin-1-yl]pyrimidin-4-yl}-2-naphthol;

2,2,2-trifluoro-N-({1-[4-(6-hydroxy-2-naphthyl)pyrimidin-2-yl]piperidin-4-yl}methyl)acetamide;

2,2,2-trifluoro-N-({1-[4-(6-methoxy-2-naphthyl)pyrimidin-2-yl]piperidin-4-yl}methyl)acetamide;

1-(1-{4-[6-(2-thienyl)-2-naphthyl]pyrimidin-2-yl}piperidin-4-yl)methanamine;

1-(1-{4-[6-(2-methoxyphenyl)-2-naphthyl]pyrimidin-2-yl}piperidin-4-yl)methanamine;

1-(1-{4-[6-(4-methoxyphenyl)-2-naphthyl]pyrimidin-2-yl}piperidin-4-yl)methanamine;

1-{1-[4-(6-phenyl-2-naphthyl)pyrimidin-2-yl]piperidin-4-yl}methanamine;

2,2,2-trifluoro-N-({1-[4-(6-formyl-2-naphthyl)pyrimidin-2-yl]piperidin-4-yl}methyl)acetamide;

1-{1-[4-(6-vinyl-2-naphthyl)pyrimidin-2-yl]piperidin-4-yl}methanamine;

1-{1-[4-(6-methyl-2-naphthyl)pyrimidin-2-yl]piperidin-4-yl}methanamine;

1-(1-{4-[6-(piperidin-1-ylmethyl)-2-naphthyl]pyrimidin-2-yl}piperidin-4-yl)methanamine;

1-(1-{4-[6-(morpholin-4-ylmethyl)-2-naphthyl]pyrimidin-2-yl}piperidin-4-yl)methanamine;

2-{4-[(4-methylpiperazin-1-yl)methyl]piperidin-1-yl}-4-(2-naphthyl)pyrimidine;

N-methyl-N-({1-[4-(2-naphthyl)pyrimidin-2-yl]piperidin-4-yl}methyl)cyclohexanamine;

1-({1-[4-(2-naphthyl)pyrimidin-2-yl]piperidin-4-yl}methyl)azepane;

2-[ethyl({1-[4-(2-naphthyl)pyrimidin-2-yl]piperidin-4-yl}methyl)amino]ethanol;

2-methyl-N-({1-[4-(2-naphthyl)pyrimidin-2-yl]piperidin-4-yl}methyl)propan-2-amine;

1-({1-[4-(2-naphthyl)pyrimidin-2-yl]piperidin-4-yl}methyl)pyrrolidin-2-one;

1-({1-[4-(2-naphthyl)pyrimidin-2-yl]piperidin-4-yl}methyl)piperidin-2-one;

4-(2-naphthyl)-2-[4-(piperazin-1-ylmethyl)piperidin-1-yl]pyrimidine;

4-({1-[4-(2-naphthyl)pyrimidin-2-yl]piperidin-4-yl}methyl)morpholine;

4-({1-[4-(2-naphthyl)pyrimidin-2-yl]piperidin-4-yl}methyl)piperazin-2-one;

1-(1-{[4-(2-naphthyl)pyrimidin-2-yl]carbonyl}piperidin-4-yl)methanamine; or

(3aR,7aS)-5-[4-(2-naphthyl)pyrimidin-2-yl]octahydro-1H-pyrrolo[3,4-c]pyridine.

34 . A compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein the compound is N,N,N′-trimethyl-N′-{(3R)-1-[4-(2-naphthyl)pyrimidin-2-yl]pyrrolidin-3-yl}ethane-1,2-diamine.

35 . A compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein the compound is ({1-[4-(2-naphthyl)pyrimidin-2-yl]piperidin-4-yl}methyl)amine.

36 . A composition comprising the compound or pharmaceutically acceptable salt of the compound of claim 1 or 30 and a pharmaceutically acceptable carrier.

37 . The composition of claim 36 , wherein the pharmaceutically acceptable carrier is suitable for oral administration and the composition comprises an oral dosage form.

38 . A method of treating a canonical Wnt-β-catenin cellular messaging system related disorder, comprising administering to a mammal in need thereof a compound or a pharmaceutically acceptable salt thereof the compound of claim 1 or 30 in an amount effect to treat a canonical Wnt-β-catenin cellular messaging system related disorder.

39 . The method of claim 38 , wherein the canonical Wnt-β-catenin cellular messaging system related disorder is selected from the group consisting of bone disorders, cancer, and Alzheimer's disease.

40 . The method of claim 39 , wherein the cancer is selected from the group consisting of leukemia, skin cancer, bladder cancer, breast cancer, uterus cancer, ovary cancer, prostate cancer, lung cancer, colon cancer, pancreas cancer, renal cancer, gastric cancer, and brain cancer.

41 . The method of claim 39 , wherein the bone disorder is selected from the group consisting of osteoarthritis, osteolysis from multiple myeloma, osteoporosis, and rheumatoid arthritis.

42 . The method of claim 38 , wherein the mammal is human.

43 . A method of synthesizing a compound of claim 9 or 30 , comprising: reacting a compound of the Formula 4:

wherein

R 6 and R 7 are independently H, halogen, CN, NO 2 , R 11 , OR 11 , S(O) x R 11 , or NR 11 R 12 ;

R 11 is H, C 1- C 6 alkyl, aryl, or alkylaryl;

R 12 is H, C 1- C 6 alkyl, aryl, alkylaryl, COR 13 , CO 2 R 13 , CONR 13 R 14 , SO 2 R 13 ; or R 11 and R 12 when taken together with the N to which they are attached form a C 3 -C 8 monocyclic cycloalkyl, a 3- to 7-membered monocyclic heterocycle, an C 8 -C 12 bicyclic cycloalkyl, or an 8- to 12-membered bicyclic heterocycle, all optionally substituted with R 11 and OR 11 ;

R 13 is H or C 1- C 6 alkyl;

R 14 is H or C 1- C 6 alkyl; or R 13 and R 14 when taken together with the N to which they are attached form a C 3 -C 8 monocyclic cycloalkyl or a 3- to 7-membered monocyclic heterocycle;

o and p are independently 0, 1 or 2;

x is 0, 1, or 2;

with a compound of formula:

HX

wherein X is a primary alkyl or aryl amine, a secondary amine, a cyclicamine, an O(alkyl), an O(aryl), an S(alkyl), or an S(aryl);

under conditions effective to substitute Cl with the X of formula HX thereby providing a compound having the Formula 5:

or pharmaceutically acceptable salts thereof.

44 . A process for preparing a compound of Formula (a)

comprising:

reacting a compound of Formula (b)

with a compound of Formula (c)

in the presence of a base

to provide a compound of Formula (a),

wherein Ar is

Q is N(CH 2 ) r R 8 or CR 8 R 9 ;

R is

wherein U, R 1 , R 2 , R 3 , R 4 , W, R 6 , R 7 , R 8 , R 9 , m, n, o, p and s are as defined in claim 1 .

45 . The process of claim 44 , the process further comprising preparing a compound of Formula (c)

by reacting a compound of Formula (d)

with DMF in the presence of DMA, to form a compound of Formula (c).

46 . The process of claim 44 , wherein the base is EtONa.