Method of reducing phosphate nephropathy in a mammal
View Patent ↗The present invention provides the invention provides methods of reducing phosphate nephropathy in a mammal suffering from impairment of renal function, including administering to the mammal an amount of citrate that is effective to reduce serum phosphorous concentration.
1. A method of reducing phosphate nephropathy in a mammal suffering from impairment of renal function, comprising:
administering to the mammal an amount of citrate effective to reduce serum phosphorous concentration, wherein the amount of citrate is 5 g to 100 g of citrate, and the citrate is selected from the group consisting of citric acid, sodium hydrogen citrate, sodium dihydrogen citrate, citrate esters and mixtures thereof.
2. The method of claim 1 , wherein the mammal has ischemia-induced renal failure.
3. The method of claim 1 , wherein the mammal has ischemic tubular injury.
4. The method of claim 1 , wherein the administering comprises administering orally a solution comprising citrate.
5. The method of claim 1 , wherein the administering comprises administering intravenously a solution comprising citrate.
6. The method of claim 1 , wherein the administering comprises administering orally a solid composition comprising citrate.
7. The method of claim 1 , wherein the administering comprises administering during dialysis.
8. The method of claim 1 , wherein the administering comprises administering from 10 g to 50 g of citrate.