Fluorescent dyes for use in glucose sensing
View Patent ↗A novel class of compounds that includes HPTS-Cys-MA, and methods of making them are disclosed herein. The class of compounds including HPTS-Cys-MA are useful as fluorescent dyes for analyte detection.
1. The compound:
wherein R 2 comprises both a sulfonic acid group or salts thereof and a polymerizable group.
2. The compound of claim 1 wherein the polymerizable group is an ethylenically unsaturated group selected from the group consisting of methacryloyl, acryloyl, styryl, acrylamido and methacrylamido.
3. The compound of claim 1 , wherein R 2 further comprises a cationic group selected from the group consisting of H + , an alkali metal ion, Li + , Na + , K + , Rb + , Cs + , Fr + , an onium ion and NR 4 + , wherein R is selected from the group consisting of alkyl, alkylaryl, and aromatic groups.
4. A glucose sensor comprising the compound of claim 1 .
5. The glucose sensor of claim 4 , further comprising a quencher moiety.
6. The glucose sensor of claim 5 , wherein said quencher moiety comprises boronic acid.
7. The glucose sensor of claim 6 , wherein said quencher moiety is 3,3′-oBBV: