Ophthalmic compositions with an amphoteric surfactant and hyaluronic acid

1. An aqueous contact lens cleaning and disinfecting solution composition comprising:

0.8 ppm to 1.6 ppm of poly(hexamethylene biguanide);

0.5 ppm to 2 ppm α-[4-tris(2-hydroxyethyl)-ammonium chloride-2-butenyl]poly[1-dimethyl ammonium chloride-2-butenyl]-ω-tris(2-hydroxyethyl)ammonium chloride;

0.005 wt. % to 0.015 wt. % hyaluronic acid;

0.01 wt. % to 0.6 wt. % of a sulfobetaine of general formula I

wherein R 1 is a C 8 -C 16 alkyl optionally substituted with at least one hydroxyl; R 2 and R 3 are each methyl; and R 4 is a C 2 -C 4 alkylene optionally substituted with one hydroxyl;

a boric acid/borate buffer;

a nonionic surfactant selected from poloxamer, poloxamine or any combination thereof; and

sodium chloride, potassium chloride or any combination thereof.

2. The ophthalmic composition of claim 1 wherein the nonionic surfactant is poloxamine with an HLB value from 13 to 28.

3. The ophthalmic composition of claim 1 wherein R 1 is a straight, saturated C 10 alkyl.

4. A method of cleaning and disinfecting a contact lens, the method comprising soaking the contact lens in the ophthalmic composition of claim 1 for at least two hours.

5. The method of claim 4 further comprising inserting the cleaned and disinfected contact lens into the eye without rinsing the lens after soaking.

6. The composition of claim 1 further comprising dexpanthenol, sorbitol, glycolic acid, 2-amino-2-methyl-1,3-propanediol or any mixture thereof.

7. The composition of claim 1 further comprising citrate, citric acid or a mixture thereof.

8. The composition of claim 1 further comprising propylene glycol, hydroxypropyl guar or myristamidopropyl dimethylamine.

9. The composition of claim 1 further comprising hydroxypropylmethyl cellulose.

10. An aqueous contact lens care solution composition comprising:

1 ppm to 1.3 ppm of poly(hexamethylene biguanide);

1 ppm α-[4-tris(2-hydroxyethyl)-ammonium chloride-2-butenyl]poly[1-dimethyl ammonium chloride-2-butenyl]-ω-tris(2-hydroxyethyl)ammonium chloride;

0.008 wt. % to 0.015 wt. % hyaluronic acid; and

a borate buffer system component selected from the group consisting of boric acid and borate.

11. The solution of claim 10 further comprising a nonionic surfactant selected from poloxamer, poloxamine or any combination thereof; and

sodium chloride, potassium chloride or any combination thereof.

12. A method of cleaning and disinfecting a contact lens, the method comprising soaking the contact lens in the ophthalmic composition of claim 10 for at least two hours.