Substituted arylsulfonamides as antiviral agents
View Patent ↗The invention relates to substituted arylsulfonamides of formula (I) and methods for their preparation as well as their use for the production of medicaments for the treatment and/or prophylaxis of diseases, especially for use as antiviral agents, particularly against cytomegaloviruses.
1. A compound of formula
in which
A represents a group of formula
whereby
* is the linkage site to the carbon atom of the pyridinyl ring, and
# is the linkage site to the carbon atom of the phenyl ring,
R 1 represents hydrogen, amino or methylcarbonylamino,
R 2 represents hydrogen or halogen,
R 3 represents hydrogen, halogen or cyano,
R 4 represents hydrogen, halogen or cyano,
R 5 represents hydrogen or halogen,
R 6 represents hydrogen or halogen,
R 7 represents hydrogen, halogen or C 1 -C 3 -alkyl, and
R 8 represents hydrogen, halogen or C 1 -C 3 -alkyl,
or one of its salts.
2. The compound of claim 1 , whereby
A represents a group of formula
whereby
* is the linkage site to the carbon atom of the pyridinyl ring, and
# is the linkage site to the carbon atom of the phenyl ring,
R 1 represents hydrogen, amino or methylcarbonylamino,
R 2 , R 3 and R 4 each represent hydrogen,
R 5 represents hydrogen or halogen,
R 6 represents hydrogen or halogen, and
R 7 and R 8 each represent hydrogen,
or one of its salts.
3. The compound of claim 1 , whereby
A represents a group of formula
whereby
* is the linkage site to the carbon atom of the pyridinyl ring, and
# is the linkage site to the carbon atom of the phenyl ring,
R 1 represents amino or methylcarbonylamino,
R 2 , R 3 and R 4 each represent hydrogen,
R 5 represents hydrogen,
R 6 represents hydrogen or halogen, and
R 7 and R 8 each represent hydrogen,
or one of its salts.
4. A method for the preparation of a compound of formula (I) of claim 1 , comprising reacting a compound of formula
in which
A, R 1 , R 2 , R 3 , R 4 , R 5 and R 6 have the meaning indicated in claim 1 , with a compound of formula
in which
R 7 and R 8 have the meaning indicated in claim 1 , and
X 1 represents halogen or hydroxy.
5. A medicament comprising a therapeutically effective amount of a compound of claim 1 in combination with an inert, non-toxic, pharmaceutically acceptable excipient.
6. A method for the production of a medicament for the treatment of viral infections, comprising mixing a therapeutically effective amount of a compound of claim 1 with at least one pharmaceutically acceptable excipient, wherein the viral infection is an infection with the human cytomegalovirus (HCMV) or another representative of the group of herpes viridae.
7. A method of controlling viral infections in humans and animals by administering an antivirally effective amount of at least one compound of claim 1 , wherein the viral infection is an infection with the human cytomegalovirus (HCMV) or another representative of the group of herpes viridae.
8. The method of claim 4 , wherein X 1 is chlorine, bromine, or hydroxy.