Diagnostic And Therapeutic Uses Of Augmenter Of Liver Regeneration In Inflammatory Conditions
The present invention provides for methods and kits for detecting sepsis, trauma/hemorrhage or inflammation in a subject. It is based, at least in part, on the discovery that Augmenter of Liver Regeneration (“ALR”) is an early marker of these conditions. Accordingly, in other embodiments, the present invention provides for a method of treating sepsis, traumatic/hemorrhagic shock and inflammation by inhibiting ALR.
1 . A method of detecting sepsis in a subject, comprising measuring the level of Augmenter of Liver Regeneration in a sample collected from a subject to be tested for sepsis, and comparing the level to a baseline value, wherein an elevation in the level of Augmenter of Liver Regeneration relative to baseline is an indicator that the subject suffers from sepsis.
2 . The method of claim 1 , where the level of Augmenter of Liver Regeneration is measured by an enzyme-linked immunosorbent assay.
3 . A method of detecting inflammation in a subject, comprising measuring the level of Augmenter of Liver Regeneration in a sample collected from a subject to be tested for inflammation, and comparing the level to a baseline value, wherein an elevation in the level of Augmenter of Liver Regeneration relative to baseline is an indicator that the subject suffers from inflammation.
4 . The method of claim 3 , where the level of Augmenter of Liver Regeneration is measured by an enzyme-linked immunosorbent assay.
5 . A method of detecting traumatic/hemorrhagic shock in a subject, comprising measuring the level of Augmenter of Liver Regeneration in a sample collected from a subject to be tested for inflammation, and comparing the level to a baseline value, wherein an elevation in the level of Augmenter of Liver Regeneration relative to baseline is an indicator that the subject suffers from inflammation.
6 . The method of claim 5 , where the level of Augmenter of Liver Regeneration is measured by an enzyme-linked immunosorbent assay.
7 . A method of treating sepsis, comprising administering, to a subject suffering from sepsis, an effective amount of an inhibitor of Augmenter of Liver Regeneration.
8 . A method of treating inflammation, comprising administering, to a subject suffering from inflammation, an effective amount of an inhibitor of Augmenter of Liver Regeneration.
9 . A method of treating traumatic/hemorrhagic shock, comprising administering, to a subject suffering from inflammation, an effective amount of an inhibitor of Augmenter of Liver Regeneration.