Method for treating obesity
View Patent ↗The present invention relates, in general, to obesity, and, in particular, to a method of treating obesity and minimizing metabolic risk factors associated therewith using, for example, zonisamide or other weight-loss promoting anticonvulsant either alone or in combination with bupropion or other compound that enhances the activity of norepinephrine and/or dopamine via uptake inhibition or other mechanism.
1. A method of reducing the weight of an overweight subject, said method comprising: identifying an overweight subject and administering to said overweight subject a pharmaceutical composition comprising a sustained release formulation of zonisamide, or a pharmaceutically acceptable salt thereof, in an amount effective to reduce the weight of said subject.
2. The method according to claim 1 , wherein said effective amount of zonisamide is in the range of about 25 to about 800 mg/day.
3. The method according to claim 2 , wherein said effective amount of zonisamide is in the range of about 100 to about 600 mg/day.
4. The method according to claim 1 , wherein said overweight subject is an obese subject.
5. The method according to claim 1 , wherein said pharmaceutical composition is administered in combination with a reduced calorie diet or increased physical activity.
6. A method of reducing weight in an overweight subject, said method comprising: identifying an overweight subject and administering to said overweight subject a pharmaceutical composition comprising a sustained release formulation of zonisamide, or a pharmaceutically acceptable salt thereof, in an amount effective to induce weight loss in said subject, wherein the weight loss is ≧5%, or wherein said weight loss continues during the period of administration of said pharmaceutical composition.
7. The method according to claim 6 , wherein said effective amount of zonisamide is in the range of about 25 to about 800 mg/day.
8. The method according to claim 6 , wherein said effective amount of zonisamide is in the range of about 100 to about 600 mg/day.
9. The method according to claim 6 , wherein said overweight subject is an obese subject.
10. The method according to claim 6 , wherein said pharmaceutical composition is administered in combination with a reduced calorie diet or increased physical activity.
11. A method of treating obesity by reducing the weight of an obese subject, said method comprising: identifying an obese subject and administering to said obese subject an effective amount of a pharmaceutical composition comprising a sustained release formulation of zonisamide, or a pharmaceutically acceptable salt thereof.
12. The method according to claim 11 , wherein said obese subject has a BMI of at least 30 kg/m 2 .