Demineralized bone-derived implants
View Patent ↗Selectively demineralized bone-derived implants are provided. In one embodiment, a bone sheet for implantation includes a demineralized field surrounding mineralized regions. In another embodiment, a bone defect filler includes a demineralized cancellous bone section in a first geometry. The first geometry is compressible and dryable to a second geometry smaller than the first geometry, and the second geometry is expandable and rehydratable to a third geometry larger than the second geometry.
1. An implant comprising a unitary section of cortical bone having a first portion that is mineralized and a second portion that is at least partially demineralized, wherein the mineralized portion includes a plurality of slits to facilitate bending of the unitary section.
2. The implant of claim 1 , wherein the second portion is fully demineralized.
3. The implant of claim 1 , wherein the first and second portions are a monolithic layer of bone.
4. The implant of claim 1 , wherein the implant is insertable into an intervertebral disk space.
5. An allograft implant comprising at least two superimposed layers of allograft bone, one layer being at least partially demineralized, the other layer being mineralized, wherein the mineralized bone layer includes a plurality of slits to facilitate bending of the implant, the at least partially demineralized layer having a longitudinal axis and the mineralized layer having a longitudinal axis, the longitudinal axis of the at least partially demineralized layer being parallel to the longitudinal axis of the mineralized layer.
6. The implant of claim 5 , wherein the at least partially demineralized bone layer comprises fully demineralized bone.
7. The implant of claim 5 , wherein the at least partially demineralized bone layer and the mineralized bone layer are a monolithic layer of bone.
8. The implant of claim 5 , wherein the implant is insertable into an intervertebral disk space.
9. The implant of claim 5 , wherein the at least partially demineralized bone layer is a monolithic layer of bone.
10. An allograft implant comprising a layer of least partially demineralized allograft bone and a plurality of discrete, mineralized bone sections, the at least partially demineralized bone layer being coupled to each of the plurality of discrete, mineralized bone sections along a single side thereof.
11. The implant of claim 10 , wherein the at least partially demineralized bone layer comprises fully demineralized bone.
12. The implant of claim 10 , wherein the implant is insertable into an intervertebral disk space.
13. The implant of claim 10 , wherein the at least partially demineralized bone layer is a monolithic layer of bone.