Fluid titration system

1. A fluid titration system comprising:

an optical sensor that transmits multiple wavelengths of optical radiation into a tissue site of a person and detects the optical radiation after attenuation by pulsatile blood flowing within the tissue site so as to generate a sensor signal responsive to the detected optical radiation;

a physiological monitor in electrical communications with the optical sensor, the physiological monitor configured to calculate a measure of plethysmograph variability (PV) from the sensor signal; and

an infusion device that administers a liquid solution via an intravenous (IV) connection to the person in response to the measure of PV.

2. The fluid titration system according to claim 1 further comprising a fluid titration controller, the fluid titration controller comprising:

a PV measure input;

a fluid control output; and

a predetermine relationship between the PV measure input and the fluid control output,

wherein the control output is in communication with the infusion device so as to regulate at least one of fluid flow start, rate and stop.

3. The fluid titration system according to claim 2 wherein the PV measure is responsive to changes in perfusion index (PI) over a time interval where one or more complete respiratory cycles have occurred.

4. The fluid titration system according to claim 3 further comprising:

a digital signal processor (DSP); and

a closed-loop fluid titration algorithm implemented in firmware executing on the DSP so as to implement the predetermined relationship.

5. The fluid titration system according to claim 4 further comprising an enclosure integrating the physiological monitor with the infusion device.

6. A fluid titration method comprising:

deriving a plethysmograph waveform from an optical sensor attached to a person;

determining a measure of perfusion variability corresponding to the plethysmograph waveform; and

adjusting blood volume for the person based upon the perfusion variability metric.

7. The fluid titration method according to claim 6 wherein determining a measure of perfusion variability comprises calculating a perfusion variability index based upon a maximum perfusion measurement compared to a minimum perfusion measurement.

8. The fluid titration method according to claim 7 wherein adjusting comprises displaying an IV infusion device adjustment prompt to a care provider according to the perfusion variability index.

9. The fluid titration method according to claim 7 wherein adjusting comprises transmitting a control signal to an IV infusion device according to the perfusion variability index.

10. The fluid titration method according to claim 9 wherein the transmitting comprises at least one of:

disabling the IV infusion device from infusing fluid when PVI is less than a first predetermined threshold; and

enabling the IV infusion device for infusing fluid when PVI is greater than a second predetermined threshold.

11. A fluid titration system comprising:

a sensor means for transmitting multiple wavelengths of optical radiation into a tissue site and detecting the optical radiation after attenuation by pulsatile blood flow within the tissue site;

a physiological monitor means in communications with the sensor means for deriving a plethysmograph and calculating a measure of plethysmograph variability;

an IV infusion device in communication with the fluid titration controller means configured to infuse a fluid into the person; and

a titration controller means for at least partially regulating the fluid infusion in response to the measure of plethysmograph variability.

12. The fluid titration system according to claim 11 wherein the titration controller means comprises an open loop means for utilizing a care provider to adjust the IV infusion device.

13. The fluid titration system according to claim 12 wherein the open loop means comprises an indicator means for communicating infusion adjustment to a care provider.

14. The fluid titration system according to claim 11 wherein the titration controller means comprises a closed-loop means for directly controlling fluid delivery by the IV infusion device.

15. The fluid titration system according to claim 14 wherein the closed-loop means comprises an infusion control output for transmitting a control signal to the IV infusion device.

16. A fluid titration method comprising:

deriving a plethysmograph in response to an optical sensor attached to a person, the plethysmograph having a plurality of pulses in response to the person's arterial blood flow, the pulse minima of the plethysmograph defining a baseline;

calculating a parameter indicative of a variability of the plethysmograph;

infusing fluid into the person via an IV; and

regulating the infusing according to the parameter.

17. The fluid titration method according to claim 16 wherein the calculating comprises:

determining a plurality of perfusion measures corresponding to physiologically acceptable ones of the pulses; and

computing a perfusion variation from the perfusion measures.

18. The intravenous fluid titration method according to claim 17 wherein the infusing comprises:

connecting an IV infusion device to the IV; and

communicating an infusion control to the IV infusion device,

wherein fluid flow from the IV infusion device is determined by the infusion control.

19. The intravenous fluid titration method according to claim 18 wherein the regulating comprises outputting a disabling signal on the infusion control when the variability parameter is below a predetermined threshold.

20. The intravenous fluid titration method according to claim 18 wherein the regulating comprises outputting an enabling signal on the infusion control when the parameter is above a predetermined threshold.