Methods for treating blood disorders
Methods of treating blood disorders are described.
1. A method for treating a blood disorder in a subject in need thereof comprising administering to said subject an effective amount of a compound comprising:
wherein the blood disorder to be treated is selected from the group consisting of anemia, sickle cell anemia, .beta.-thalassemia, neutropenia, and thrombocytopenia.
2. The method of claim 1 , wherein the compound stimulates fetal hemoglobin production.
3. The method of claim 1 , wherein the compound stimulates fetal hematopoiesis.
4. The method of claim 1 , wherein the compound stimulates fetal erythropoiesis.
5. The method of claim 1 , wherein the compound stimulates fetal myelopoiesis.
6. The method of claim 1 , wherein the compound stimulates neutrophil production.
7. The method of claim 1 , wherein the compound is administered in combination with one or more cytokines.
8. The method of claim 7 , wherein said one or more cytokine is selected from one or more of the group consisting of EPO, IL-3, GM-CSF, G-CSF, SCF and IL-6.
9. A method for treating a blood disorder in a subject in need thereof comprising administering to said subject an effective amount of a compound comprising:
wherein the blood disorder to be treated is selected from the group consisting of anemia, sickle cell anemia, .beta.-thalassemia, neutropenia, and thrombocytopenia.
10. The method of claim 9 , wherein the compound stimulates fetal hemoglobin production.
11. The method of claim 9 , wherein the compound stimulates fetal hematopoiesis.
12. The method of claim 9 , wherein the compound stimulates fetal erythropoiesis.
13. The method of claim 9 , wherein the compound stimulates fetal myelopoiesis.
14. The method of claim 9 , wherein the compound stimulates neutrophil production.
15. The method of claim 9 , wherein the compound is administered in combination with one or more cytokines.
16. The method of claim 15 , wherein said one or more cytokine is selected from one or more of the group consisting of EPO, IL-3, GM-CSF, G-CSF, SCF and IL-6.