Dermal filler and method of using same
View Patent ↗Polyglutamic acid (PGA) formulations are provided for use as a dermal filler. Also provided are methods of use of such formulations for treatment of cosmetic defects.
1. A method of treating a cosmetic defect in an individual, comprising:
a) formulating a water-based solution consisting of:
i) bacterially-produced polyglutamic acid (PGA) having a molecular weight above about 1 million Daltons, the PGA at a concentration of from about 1% to about 3%; and
ii) from about 0.1% to about 1% of a counter cationic salt; and
b) subdermally injecting the solution proximate a cosmetic defect that is selected from the group consisting of wrinkles, marrionette lines, glabellar lines, crow's feet, brow furrows, and combinations thereof, thereby treating the cosmetic defect in the individual.
2. The method of claim 1 in which the cationic species comprises calcium.
3. The method of claim 2 , wherein the composition further comprises an agent selected from the group of agents consisting of a Botulinum toxin, autologous fat, collagen, hydroxyapatite, and hyaluronic acid.
4. The method of claim 3 , wherein the injection is accomplished using a needle of about 30 gauge.