Method for treating a motoneuron disorder
View Patent ↗The present invention is directed to the use of a class of peptide compounds for treating amyotrophic lateral sclerosis (ALS) and other forms of motoneuron diseases and peripheral neuropathies.
1. A method for treating a motoneuron disorder in a subject, comprising administering to the subject a therapeutically effective amount of lacosamide or a pharmaceutically acceptable salt thereof;
wherein the motoneuron disorder is selected from the group consisting of amyotrophic lateral sclerosis, progressive spinal muscular atrophies, progressive bulbar palsy, Guillain-Barré syndrome and Charcot-Marie-Tooth syndrome.
2. The method of claim 1 , wherein lacosamide or salt thereof is administered at a dose of 50 mg/day to 6 g/day.
3. The method of claim 1 , wherein lacosamide or salt thereof is administered at a dose of 100 to 600 mg/day.
4. The method of claim 1 , wherein lacosamide or salt thereof is administered in a pharmaceutical composition further comprising one or more excipients.
5. The method of claim 4 , wherein the composition is administered no more than three times per day.
6. The method of claim 4 , wherein the composition and a dose and frequency of administration are selected to result in a plasma concentration of lacosamide of 0.1 to 15 μg/ml (trough) and 5 to 18.5 μg/ml (peak).
7. The method of claim 4 , wherein the composition is administered orally or intravenously.
8. The method of claim 1 , wherein the subject is a mammal.
9. The method of claim 1 , wherein the subject is human.
10. The method of claim 9 , wherein the motoneuron disorder is amyotrophic lateral sclerosis.
11. The method of claim 1 , wherein lacosamide is administered to the subject.