IP Library › Granted Patent US 7,803,362
Granted Patent B2
US 7,803,362 · App. 12/217,352 · Granted Sep 28, 2010

Glycosylated interferon alpha

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Quick Facts
Patent No.
US 7,803,362
App. No.
12/217,352
Granted
Sep 28, 2010
Kind
B2
Abstract

The invention relates to interferon-α molecules having certain O-linked oligosaccharide structures.

Claims (29)

1. A composition comprising an interferon-α molecule glycosylated with:

Gal-NAcGal-,

wherein

Gal=Galactose, and

NAcGal=N-Acetyl-Galactosamine.

2. The composition of claim 1 wherein the composition is a pharmaceutical composition.

3. The composition of claim 1 wherein the interferon-α is interferon-α2.

4. The composition of claim 1 wherein the interferon-α is interferon-α2b.

5. The composition of claim 1 wherein the glycosylation is O-linked at Thr-106.

6. The composition of claim 1 wherein the interferon-α is human interferon-α.

7. The composition of claim 1 wherein the interferon-α is pegylated.

8. A composition comprising an interferon-α molecule glycosylated with:

Gal-Gal-NAcGal-,

wherein

Gal=Galactose, and

NAcGal=N-Acetyl-Galactosamine,

wherein the glycosylation is O-linked at Thr-106.

9. A composition comprising an interferon-α molecule glycosylated with:

Gal-Gal-NAcGal-,

wherein

Gal=Galactose, and

NAcGal=N-Acetyl-Galactosamine,

wherein the interferon-α is human interferon-α.

10. A composition comprising an interferon-α molecule glycosylated with:

Gal-Gal-NAcGal-,

wherein

Gal=Galactose, and

NAcGal=N-Acetyl-Galactosamine,

wherein the interferon-α is pegylated.

Assignments (3)
CHANGE OF NAME Recorded Jan 30, 2009
From: AVIGENICS, INC.
To: SYNAGEVA BIOPHARMA CORP.
Reel/Frame 022177/0940 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Dec 19, 2008
From: IVARIE, ROBERT D.; MORRIS, JULIE A.; LIU, GUODONG
To: UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC.
Reel/Frame 022032/0958 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Dec 19, 2008
From: HARVEY, ALEX J.; RAPP, JEFFREY C.
To: AVIGENICS, INC.
Reel/Frame 022033/0542 →