Luminogenic and fluorogenic compounds and methods to detect molecules or conditions
View Patent ↗A method to detect the presence or amount of at least one molecule in a sample which employs a derivative of luciferin or a derivative of a fluorophore is provided. Compounds and compositions for carrying out the methods of the invention are also provided.
1. A compound according to formula VI:
wherein R 1 is —NR N1 R N2 ; wherein R N1 is H, C 3-8 alkyl which may be substituted with hydroxyl, halo, or amino, or —CH 2 -A 1 or —CH 2 -A 2 ;
R N2 is C 3-8 alkyl which may be substituted with hydroxyl, halo, or amino or —CH 2 -A 1 or —CH 2 -A 2 ; or
A 1 is C 6-10 aryl or C 6-10 heteroaryl, which may be substituted with hydroxyl, halo, or amino;
A 2 is C 6 aryl or C 6 heteroaryl, which may be substituted with hydroxyl, halo, or amino; and only one of R N1 or R N2 may be —CH 2 -A 1 ;
R 6 is COR 11 wherein R 11 is OH;
R 7 is H.
2. A compound selected from the group consisting of