Method for producing 1,4-bis(difluoromethyl)tetrafluorobenzene
View Patent ↗A method for producing 1,4-bis(difluoromethyl)tetrafluorobenzene is disclosed, which has the following steps: (a) mixing 1,4-bis(dichloromethyl)tetrafluorobenzene, a catalyst, an aprotic polar solvent, and an alkali metal fluoride to form a reaction mixture; (b) heating the reaction mixture; and (c) purifying the resultant to obtain 1,4-bis(difluoromethyl)tetrafluorobenzene.
1. A method for producing 1,4-bis(difluoromethyl)tetrafluorobenzene, comprising the following steps:
(a) mixing 1,4-bis(dichloromethyl)tetrafluorobenzene, a catalyst, an aprotic polar solvent, and an alkali metal fluoride to form a reaction mixture;
(b) heating the reaction mixture to perform a reaction; and
(c) purifying the reaction mixture to obtain 1,4-bis(difluoromethyl)tetrafluorobenzene.
2. The method as claimed in claim 1 , wherein the step (a) comprises the following steps:
(a1) mixing 1,4-bis(dichloromethyl)tetrafluorobenzene, a catalyst, and an aprotic polar solvent in a reactor to form a mixture;
(a2) heating the mixture until the 1,4-bis(dichloromethyl)tetrafluorobenzene dissolves; and
(a3) adding an alkali metal fluoride to the mixture to form the reaction mixture.
3. The method as claimed in claim 1 , wherein the reaction time of the step (b) is in the range of from 1 to 48 hours.
4. The method as claimed in claim 1 , wherein the reaction temperature of the step (b) is in the range of from 40 to 160° C.
5. The method as claimed in claim 1 , wherein the catalyst is at least one selected from the group consisting of quaternary ammonium salt, quaternary phosphonium salt, and crown ether.
6. The method as claimed in claim 5 , wherein the quaternary ammonium salt is tetramethyl ammonium chloride.
7. The method as claimed in claim 5 , wherein the quaternary phosphonium salt is tetraphenylphosphonium bromide.
8. The method as claimed in claim 5 , wherein the crown ether is 18-crown-6-ether.
9. The method as claimed in claim 1 , wherein the aprotic polar solvent is acetonitrile, sulpholane, or N,N-dimethylformamide.
10. The method as claimed in claim 1 , wherein the alkali metal fluoride is KF or CsF.
11. The method as claimed in claim 1 , wherein the mole number of the alkali metal fluoride is in the range of from 1-fold to 16-fold greater than that of 1,4-bis(dichloromethyl)tetrafluorobenzene.
12. The method as claimed in claim 1 , wherein the amount of the catalyst is in the range of from 1 to 40% wt based on 1,4-bis(dichloromethyl)tetrafluorobenzene.
13. The method as claimed in claim 1 , wherein purifying in the step (c) is to filtrate, extract, distil, and sublimate the reaction mixture.