IP Library › Patent Application 12223042
Patent Application
App. No. 12/223,042

Ret Tyrosine Kinase Inhibition

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Quick Facts
Patent No.
US None
App. No.
12/223,042
Abstract

The present invention provides methods for inhibiting RET tyrosine kinase. Further, the present invention also provides methods of treating or preventing thyroid cancer.

Claims (11)

1 . A method for treating thyroid cancer in a patient comprising administering to the patient a therapeutically effective amount of:

or a pharmaceutically acceptable salt thereof.

2 . The method according to claim 1 wherein the thyroid cancer is papillary thyroid carcinoma.

3 . The method according to claim 1 wherein the thyroid cancer is medullary thyroid carcinoma.

4 . The method according to claim 1 wherein the thyroid cancer is multiple endocrine neoplasia type 2A.

5 . The method according to claim 1 wherein the thyroid cancer is multiple endocrine neoplasia type 2B.

6 . The method according to claim 1 wherein the thyroid cancer is familial medullary thyroid cancer.

7 . The method according to claim 1 wherein the thyroid cancer is pheochromocytoma.

8 . The method according to claim 1 wherein the thyroid cancer is paraganglioma.

9 . A method for inhibiting RET tyrosine kinase, comprising contacting:

or a pharmaceutically acceptable salt thereof, and the RET tyrosine kinase.

Assignments (2)
CHANGE OF NAME Recorded Jan 26, 2010
From: MERCK & CO., INC.
To: MERCK SHARP & DOHME CORP.
Reel/Frame 023845/0940 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jul 31, 2009
From: BUSER-DOEPNER, CAROLYN A.; FREEDMAN, STEVEN J.; PICKETT, CHERYL A.
To: MERCK & CO., INC.
Reel/Frame 023034/0893 →