Substituted 4-phenyl piperidines for use as renin inhibitors
View Patent ↗Compounds of the general formula (I) and the salts thereof, preferably the pharmaceutically acceptable salts thereof; in which R 1 is straight-chain C 1-8 -alkanoyloxy, straight-chain C 1-8 -alkoxy, straight-chain C 1-8 -alkoxy-straight-chain-C 1-8 -alkoxy, straight-chain C 1-8 -alkoxycarbonylamino, straight-chain C 0-8 -alkylcarbonylamino, optionally N-mono- or N,N-di-C 1-8 -alkylated amino or hydroxy or straight-chain omega-hydroxy-C 1-8 -alkyl.
1. A compound of the formula
or its pharmaceutically acceptable salt, in which
R 1 is straight-chain C 1-8 -alkanoyloxy, straight-chain C 1-8 -alkoxy, straight-chain C 1-8 -alkoxy-straight-chain-C 1-8 -alkoxy, straight-chain C 1-8 -alkoxycarbonylamino, straight-chain C 0-8 -alkylcarbonylamino, optionally N-mono- or N,N-di-C 1-8 -alkylated amino or hydroxy or straight-chain omega-hydroxy-C 1-8 -alkyl.
2. A compound or its pharmaceutically acceptable salt according to claim 1 1 , in which
R 1 is hydroxy or straight-chain omega-hydroxy-C 1-8 -alkyl.
3. A compound or its pharmaceutically acceptable salt according to claim 1 , in which
R 1 is straight-chain C 1-8 -alkoxy or straight-chain C 1-8 -alkoxy-straight-chain-C 1-8 -alkoxy.
4. A compound or its pharmaceutically acceptable salt according to claim 1 , in which
R 1 is straight-chain C 1-8 -alkanoyloxy.
5. A compound or its pharmaceutically acceptable salt according to claim 1 , in which
R 1 is straight-chain C 0-8 -alkylcarbonylamino.
6. A compound or its pharmaceutically acceptable salt according to claim 1 , in which
R 1 is optionally N-mono- or N,N-di-straight-chain-C 1-8 -alkylated amino.
7. A compound or its pharmaceutically acceptable salt according to claim 1 , in which
R 1 is hydroxy, methoxy, 2-methoxy-ethoxy, acetyloxy, formamido, methylcarbonylamino or ethylcarbonylamino.
8. A pharmaceutical composition comprising a compound or its pharmaceutically acceptable salt according to claim 1 and a pharmaceutically inert inorganic or organic excipient.
9. A method for the treatment of high blood pressure, glaucoma, and myocardial infarction, which comprises administering a therapeutically effective amount of a compound or its pharmaceutically acceptable salt according to claim 1 to a person in need thereof.