IP Library › Granted Patent US 8,362,053
Granted Patent B2
US 8,362,053 · App. 12/225,571 · Granted Jan 29, 2013

Modified macrophage migration inhibitory factor inhibitors

View Patent ↗
Loading inventors, assignments & file history…
Monitor This Case
Get email alerts when status or documents change.
Order Certified Copies
Most orders are placed with the USPTO same day — all within 24 business hours.
Order via The Patent Place →
Pre-filled with this patent's details
Quick Facts
Patent No.
US 8,362,053
App. No.
12/225,571
Granted
Jan 29, 2013
Kind
B2
Abstract

Provided are various compounds of Formula I (I). Also provided are various compounds of Formula II (II). Also provided are pharmaceutical compositions comprising the above compounds. Additionally, methods of inhibiting macrophage migration inhibitory factor (MIF) activity in a mammal are provided, as are methods of treating or preventing inflammation in a mammal. Further provided are methods of treating a mammal having sepsis, septicemia, and/or endotoxic shock. Also provided are methods of treating a mammal having an autoimmune disease, and methods of treating a mammal having a tumor.

Claims (19)

1. A compound of Formula I:

wherein R1 is a straight or branched C 3 -C 10 alkyl and R2, R3, R4 and R5 are independently F or H, wherein if all of R2, R3, R4 and R5 are H then R1 is

2. The compound of claim 1 , wherein only one of R2, R3, R4 and R5 is F.

3. The compound of claim 2 , wherein R2 is F.

4. The compound of claim 1 , wherein all of R2, R3, R4 and R5 is H.

5. The compound of claim 1 , wherein R2 is F.

6. The compound of claim 1 , wherein the compound is compound 17 , having the formula

7. The compound of claim 1 , wherein the compound is ISO-63, having the formula

8. The compound of claim 1 , wherein the compound is ISO-60, having the formula

9. The compound of claim 1 , wherein the compound is an (R) isomer.

10. A compound of Formula II:

wherein R1 is a straight or branched C 1 -C 10 alkyl, and R2, R3, R4 and R5 are independently F or H, provided that not all of R2, R3, R4 and R5 are H.

11. The compound of claim 10 , wherein only one of R2, R3, R4 and R5 is F.

12. The compound of claim 10 , wherein R2 is F.

13. A pharmaceutical composition comprising the compound of claim 1 , or a pharmaceutically acceptable salt thereof, in a pharmaceutically acceptable excipient.

14. The compound of claim 1 , wherein the compound is an (S) isomer.

15. The compound of claim 1 , wherein R1 is

16. The compound of claim 1 , wherein R1 is

17. The compound of claim 1 , wherein the compound is an (S) isomer.

Assignments (1)
CHANGE OF NAME Recorded Aug 20, 2019
From: THE FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH
To: THE FEINSTEIN INSTITUTES FOR MEDICAL RESEARCH
Reel/Frame 050102/0485 →