Sprayable gel-type skin/mucosa-adhesive preparation and administration system using the preparation

1. A sprayable gel-type skin/mucosa-adhesive preparation that takes a particle form after spraying, comprising a gel formulation, which contains an active pharmaceutical ingredient in a gel base material comprising a skin/mucosa-adhesive agent,

wherein the skin/mucosa-adhesive agent comprises a carboxy vinyl polymer,

the skin/mucosa-adhesive agent is treated with an outside shearing force that adjusts viscosity of the skin/mucosa-adhesive agent to be in the range of 50 mPa·s to 5000 mPa·s, and

a particle of the sprayed formulation has a viscosity retention rate of about 100%.

2. The sprayable gel-type skin/mucosa-adhesive preparation set forth in claim 1 , wherein the mucosa to which the preparation is applied is a mucosa of a nasal cavity, an eye, an ear, an oral cavity, a rectum, a vagina, or an urethra; or the skin to which the preparation is applied is skin of a hand, a finger, a leg, a body, a groin, a scalp, surroundings of an anus, or surroundings of a genitalium.

3. The sprayable gel-type skin/mucosa-adhesive preparation set forth in claim 1 , wherein the mucosa to which the preparation is applied is a mucosa of a nasal cavity.

4. The sprayable gel-type skin/mucosa-adhesive preparation set forth in claim 1 , wherein the skin/mucosa-adhesive agent contains the carboxy vinyl polymer in an amount of 0.1% (w/w) to 2.0% (w/w).

5. The sprayable gel-type skin/mucosa-adhesive preparation set forth in claim 1 , wherein the skin/mucosa-adhesive agent contains the carboxy vinyl polymer and gellan gum in a total amount of 0.2% (w/w) to 4.0% (w/w).

6. The sprayable gel-type skin/mucosa-adhesive preparation set forth in claim 4 ,

wherein the skin/mucosa-adhesive agent further comprises a viscosity modulating agent that adjusts the viscosity of the skin/mucosa-adhesive agent

7. The sprayable gel-type skin/mucosa-adhesive preparation set forth in claim 6 , wherein the viscosity modulating agent is selected from a group consisting of sodium chloride, potassium chloride and calcium chloride.

8. The sprayable gel-type skin/mucosa-adhesive preparation set forth in claim 1 , further comprising a thickening agent for the carboxy vinyl polymer, which is selected from the group consisting of a neutral amino acid or basic water-soluble amino acid and is contained in a ratio of 1: 0.5 to 1: 3 relative to the carboxy vinyl polymer by weight.

9. The sprayable gel-type skin/mucosa-adhesive preparation set forth in claim 8 , wherein the thickening agent is at least one material selected from the group consisting of arginine, lysine, and ornithine.

10. The sprayable gel-type skin/mucosa-adhesive preparation set forth in claim 1 , wherein the gel formulation contains an active pharmaceutical ingredient in an amount of 0.001-10% (w/w) in the gel formulation.

11. The sprayable gel-type skin/mucosa-adhesive preparation set forth in claim 1 , wherein the active pharmaceutical ingredient is in a dissolved state.

12. The sprayable gel-type skin/mucosa-adhesive preparation set forth in claim 1 , wherein the skin/mucosa-adhesive agent further comprises gellan gum.