Spray-drying process for the manufacture of dye-loaded particles
View Patent ↗According to a first aspect of the invention, a process is provided for the preparation of amorphous particles comprising a homogeneous distribution of one or more dyes encapsulated by an amorphous, siliceous encapsulating agent, the process comprising: (a) providing a precursor of the encapsulating agent in liquid form; (b) providing the one or more dyes in liquid form; (c) mixing the liquid forms; (d) aerosolizing the mixture to form droplets comprising the one or more dyes and encapsulating agent; and (e) heating the droplets to form the particles comprising the one or more dyes encapsulated by the siliceous encapsulating agent; wherein at least one of the liquid forms provided is aqueous and the or each aqueous liquid form is acidic. According to a second aspect of the invention, encapsulated dyes made by the process of the first aspect of the invention are provided.
1. A process for the preparation of amorphous particles comprising a homogeneous distribution of one or more dyes encapsulated by an amorphous, siliceous encapsulating agent, the process comprising:
(a) providing a precursor of the encapsulating agent in liquid form;
(b) providing the one or more dyes in liquid form;
(c) mixing the liquid forms;
(d) aerosolizing the mixture to form droplets comprising the one or more dyes and encapsulating agent; and
(e) heating the droplets to form the particles comprising the one or more dyes encapsulated by the siliceous encapsulating agent;
wherein at least one of the liquid forms provided is aqueous and the aqueous liquid form is acidic;
wherein the dye is homogeneously dispersed throughout the amorpohous particles; and wherein dye leakage is less than 5% weight of the total amount of dye incorporated into the particle.
2. The process according to claim 1 , wherein the precursor of the siliceous encapsulating agent is an organic source of silica.
3. The process according to claim 2 , wherein the source of silica is tetraethylorthosilicate.
4. The process according to claim 2 , wherein the precursor of the siliceous encapsulating agent is dissolved in a solvent.
5. The process according to claim 1 , wherein each dye is cationic.
6. The process according to claim 1 , wherein each dye is selected from the group consisting of azo dyes, indigoid dyes, triarylmethane dyes, anthraquinone dyes, xanthine dyes, natural dyes and derivatives, lakes, composites and mixtures thereof.
7. The process according to claim 1 , wherein the dye is provided in the form of an acidic, aqueous solution.
8. The process according to claim 1 , wherein the heating step (e) is undertaken at a temperature from about 100° C. to about 300° C.
9. The process according to claim 1 , comprising the additional step of:
(f) washing the particles resulting from step (e).
10. The process according to claim 2 , wherein the precursor of the siliceous encapsulating agent is selected from the group consisting of tetramethylorthosilicate, tetraethylorthosilicate, tetrapropylorthosilicate, tetraisopropylorthosilicate, tetrabutylorthosilicate, silicic acid, functionalised silica precursors and mixtures thereof.