Methods and compositions for deterring abuse of drugs susceptible to abuse and dosage forms thereof
View Patent ↗This invention relates to an abuse deterrent dosage form of opioid analgesics, wherein an analgesically effective amount of opioid analgesic is combined with a polymer to form a matrix.
1. A therapeutic pharmaceutical composition comprising:
a mixture including
(a) a water soluble drug susceptible to abuse;
(b) polyethylene oxide at about 3 to about 40 percent by weight;
(c) a disintegrant at about 2 to 25 percent by weight wherein the disintegrant is selected from the group consisting of crospovidone, sodium starch glycolate, and croscarmellose sodium; and
(d) sodium lauryl sulfate at about 1 to 10 percent by weight.
2. The therapeutic pharmaceutical composition of claim 1 , further comprising an emetic.
3. The therapeutic pharmaceutical composition of claim 2 , wherein the emetic is zinc sulfate.
4. The therapeutic pharmaceutical composition of claim 1 , wherein the polyethylene oxide has an average molecular weight ranging from 300,000 to about 5,000,000.
5. The therapeutic pharmaceutical composition of claim 1 , wherein the pharmaceutical composition is in unit dose form.
6. The therapeutic pharmaceutical composition of claim 1 , wherein the pharmaceutical composition is in suppository, capsule, caplet, pill, gel, soft gelatin capsule, or compressed tablet form.
7. The therapeutic pharmaceutical composition of claim 1 , wherein the water soluble drug susceptible to abuse is present in an amount of 0.5 to about 25 percent by weight.