IP Library › Granted Patent US 8,212,079
Granted Patent B2
US 8,212,079 · App. 12/234,093 · Granted Jul 3, 2012

Cocrystallization

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Quick Facts
Patent No.
US 8,212,079
App. No.
12/234,093
Granted
Jul 3, 2012
Kind
B2
Abstract

The present disclosure relates to novel cocrystals and novel methods for cocrystallization. In particular, the disclosure includes cocrystals comprising a salt of an active agent, such as a chloride salt of an active pharmaceutical ingredient. The present disclosure also relates to methods of preparing cocrystals and methods for screening for solid state phases.

Claims (6)

1. A method of modifying one or more physical properties of fluoxetine HCl comprising the steps of:

dissolving fluoxetine HCl and a guest capable of coordinating with an anion of fluoxetine HCl via hydrogen bonding in an organic solvent to make a solution of fluoxetine HCl and the guest, and

subjecting the solution to crystallization conditions to form a cocrystal of fluoxetine HCl and the guest,

wherein the guest is selected from benzoic acid, succinic acid, and fumaric acid.

2. The method of claim 1 further comprising the steps of measuring the solubility of the cocrystal of fluoxetine HCl and the guest and measuring the solubility of fluoxetine HCl.

3. The method of claim 1 further comprising, prior to the dissolving step, the step of preparing a physical mixture of fluoxetine HCl and the guest.

Assignments (18)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Nov 26, 2025
From: CURIA INDIANA, LLC
To: CURIA GLOBAL, INC.
Reel/Frame 073047/0677 →
CHANGE OF NAME Recorded May 20, 2025
From: AMRI SSCI, LLC
To: CURIA INDIANA, LLC
Reel/Frame 071298/0518 →
ASSIGNMENT OF SECURITY INTEREST IN INTELLECTUAL PROPERTY, RECORDED ON MARCH 16, 2023, AT REEL/FRAME 063008/0046 Recorded Mar 17, 2025
From: BARCLAYS BANK PLC, AS EXISTING AGENT
To: APOLLO ADMINISTRATIVE AGENCY LLC, AS SUCCESSOR AGENT
Reel/Frame 070531/0241 →
ASSIGNMENT OF SECURITY INTEREST IN INTELLECTUAL PROPERTY, RECORDED ON SEPTEMBER 1, 2017, AT REEL/FRAME 043746/0621 Recorded Mar 17, 2025
From: BARCLAYS BANK PLC, AS EXISTING AGENT
To: APOLLO ADMINISTRATIVE AGENCY LLC, AS SUCCESSOR AGENT
Reel/Frame 070531/0279 →
SECURITY INTEREST Recorded Mar 16, 2023
From: CURIA INDIANA, LLC (F/K/A AMRI SSCI, LLC)
To: BARCLAYS BANK PLC, AS COLLATERAL AGENT
Reel/Frame 063008/0046 →
SECURITY INTEREST Recorded Mar 16, 2023
From: CURIA INDIANA, LLC (F/K/A AMRI SSCI, LLC)
To: WILMINGTON TRUST, NATIONAL ASSOCIATION, AS COLLATERAL AGENT
Reel/Frame 063008/0185 →
SECURITY INTEREST Recorded Sep 6, 2021
From: CURIA GLOBAL, INC. (FKA ALBANY MOLECULAR RESEARCH, INC.); CURIA MASSACHUSETTS, INC. (FKA AMRI BURLINGTON, INC.); CURIA WISCONSIN, INC. (FKA CEDARBURG PHARMACEUTICALS, INC.); CURIA INDIANA, LLC (FKA AMRI SSCI, LLC); CURIA NEW MEXICO, LLC (FKA OSO BIOPHARMACEUTICALS MANUFACTURING, LLC); CURIA IP HOLDINGS, LLC
To: WILMINGTON TRUST, NATIONAL ASSOCIATION, AS COLLATERAL AGENT
Reel/Frame 057423/0665 →
RELEASE OF SECURITY INTEREST Recorded Oct 29, 2020
From: MORGAN STANLEY SENIOR FUNDING, INC., AS COLLATERAL AGENT
To: ALBANY MOLECULAR RESEARCH, INC.; AMRI BURLINGTON, INC.; CEDARBURG PHARMACEUTICALS, INC.; EUTICALS INC.; OSO BIOPHARMACEUTICALS MANUFACTURING, LLC
Reel/Frame 054252/0687 →
FIRST LIEN SECURITY AGREEMENT Recorded Sep 1, 2017
From: ALBANY MOLECULAR RESEARCH, INC.; AMRI BURLINGTON, INC.; CEDARBURG PHARMACEUTICALS, INC.; EUTICALS INC.; OSO BIOPHARMACEUTICALS MANUFACTURING, LLC-BY ITS SOLE MEMBER: ALO ACQUISITION LLC
To: BARCLAYS BANK, PLC AS COLLATERAL AGENT
Reel/Frame 043746/0621 →
SECOND LIEN SECURITY AGREEMENT Recorded Sep 1, 2017
From: ALBANY MOLECULAR RESEARCH, INC.; AMRI BURLINGTON, INC.; CEDARBURG PHARMACEUTICALS, INC.; EUTICALS INC.; OSO BIOPHARMACEUTICALS MANUFACTURING LLC-BY ITS SOLE MEMBER:ALO ACQUISITION LLC
To: MORGAN STANLEY SENIOR FUNDING, INC.
Reel/Frame 043746/0657 →
RELEASE OF SECURITY INTEREST Recorded Aug 31, 2017
From: BARCLAYS BANK PLC, AS COLLATERAL AGENT
To: ALBANY MOLECULAR RESEARCH, INC.; ALO ACQUISITION LLC; AMRI BURLINGTON, INC.; AMRI RENSSELAER, INC.; CEDARBURG PHARMACEUTICALS, INC.; OSO BIOPHARMACEUTICALS MANUFACTURING, LLC; AMRI SSCI, LLC; EUTICALS INC.
Reel/Frame 043742/0085 →
SECURITY INTEREST Recorded May 26, 2015
From: AMRI SSCI, LLC
To: BARCLAYS BANK PLC, AS THE COLLATERAL AGENT
Reel/Frame 035710/0880 →
ASSIGNMENT EFFECTIVE 13 FEB 2015 Recorded Apr 23, 2015
From: APTUIT (WEST LAFAYETTE), LLC
To: AMRI AMERICIUM, LLC
Reel/Frame 035492/0830 →
CHANGE OF NAME Recorded Apr 23, 2015
From: AMRI AMERICIUM, LLC
To: AMRI SSCI, LLC
Reel/Frame 035487/0184 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Oct 25, 2014
From: CHILDS, SCOTT L.
To: SSCI, INC
Reel/Frame 034034/0725 →
MERGER Recorded Oct 25, 2014
From: SSCI, INC
To: APTUIT (KANSAS CITY), LLC
Reel/Frame 034034/0716 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Mar 9, 2012
From: APTUIT (KANSAS CITY), LLC
To: APTUIT (WEST LAFAYETTE), LLC
Reel/Frame 027835/0137 →
MERGER Recorded Dec 20, 2008
From: SSCI, INC.
To: APTUIT (KANSAS CITY), LLC
Reel/Frame 022012/0049 →